File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: A Pontine Region is a Neural Correlate of the Human Affective Processing Network

TitleA Pontine Region is a Neural Correlate of the Human Affective Processing Network
Authors
KeywordsEmotion
FMRI
Pons
Raphe Nuclei
Small-World Connectivity
Issue Date2015
PublisherElsevier: Creative Commons. The Journal's web site is located at http://www.ebiomedicine.com
Citation
EBioMedicine, 2015, v. 2 n. 11, p. 1799-1805 How to Cite?
AbstractThe in vivo neural activity of the pons during the perception of affective stimuli has not been studied despite the strong implications of its role in affective processing. To examine the activity of the pons during the viewing of affective stimuli, and to verify its functional and structural connectivity with other affective neural correlates, a multimodal magnetic resonance imaging methodology was employed in this study. We observed the in vivo activity of the pons when viewing affective stimuli. Furthermore, small-world connectivity indicated that the functional connectivity (FC) between the pons and the cortico-limbic affective regions was meaningful, with the coefficient λ being positively associated with self-reported emotional reactivity. The FC between the pons and the cortico-limbic-striatal areas was related to self-reported negative affect. Corroborating this finding was the observation that the tract passing through the pons and the left hippocampus was negatively related to self-reported positive affect and positively correlated with emotional reactivity. Our findings support the framework that the pons works conjunctively with the distributed cortico-limbic-striatal systems in shaping individuals' affective states and reactivity. Our work paves the path for future research on the contribution of the pons to the precipitation and maintenance of affective disorders.
Persistent Identifierhttp://hdl.handle.net/10722/230572
ISSN
2023 Impact Factor: 9.7
2023 SCImago Journal Rankings: 3.193
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, TMC-
dc.contributor.authorSun, D-
dc.contributor.authorWong, NML-
dc.contributor.authorShao, R-
dc.contributor.authorMen, W-
dc.contributor.authorGe, J-
dc.contributor.authorSo, KF-
dc.contributor.authorGao, JH-
dc.contributor.authorChan, CCH-
dc.date.accessioned2016-08-23T14:17:49Z-
dc.date.available2016-08-23T14:17:49Z-
dc.date.issued2015-
dc.identifier.citationEBioMedicine, 2015, v. 2 n. 11, p. 1799-1805-
dc.identifier.issn2352-3964-
dc.identifier.urihttp://hdl.handle.net/10722/230572-
dc.description.abstractThe in vivo neural activity of the pons during the perception of affective stimuli has not been studied despite the strong implications of its role in affective processing. To examine the activity of the pons during the viewing of affective stimuli, and to verify its functional and structural connectivity with other affective neural correlates, a multimodal magnetic resonance imaging methodology was employed in this study. We observed the in vivo activity of the pons when viewing affective stimuli. Furthermore, small-world connectivity indicated that the functional connectivity (FC) between the pons and the cortico-limbic affective regions was meaningful, with the coefficient λ being positively associated with self-reported emotional reactivity. The FC between the pons and the cortico-limbic-striatal areas was related to self-reported negative affect. Corroborating this finding was the observation that the tract passing through the pons and the left hippocampus was negatively related to self-reported positive affect and positively correlated with emotional reactivity. Our findings support the framework that the pons works conjunctively with the distributed cortico-limbic-striatal systems in shaping individuals' affective states and reactivity. Our work paves the path for future research on the contribution of the pons to the precipitation and maintenance of affective disorders.-
dc.languageeng-
dc.publisherElsevier: Creative Commons. The Journal's web site is located at http://www.ebiomedicine.com-
dc.relation.ispartofEBioMedicine-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectEmotion-
dc.subjectFMRI-
dc.subjectPons-
dc.subjectRaphe Nuclei-
dc.subjectSmall-World Connectivity-
dc.titleA Pontine Region is a Neural Correlate of the Human Affective Processing Network-
dc.typeArticle-
dc.identifier.emailLee, TMC: tmclee@hku.hk-
dc.identifier.emailShao, R: rshao@hku.hk-
dc.identifier.emailSo, KF: hrmaskf@hku.hk-
dc.identifier.authorityLee, TMC=rp00564-
dc.identifier.authoritySun, D=rp00873-
dc.identifier.authoritySo, KF=rp00329-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.ebiom.2015.10.020-
dc.identifier.pmid26870804-
dc.identifier.pmcidPMC4740328-
dc.identifier.scopuseid_2-s2.0-84958950424-
dc.identifier.hkuros261589-
dc.identifier.hkuros261590-
dc.identifier.hkuros264851-
dc.identifier.volume2-
dc.identifier.issue11-
dc.identifier.spage1799-
dc.identifier.epage1805-
dc.identifier.isiWOS:000365962100044-
dc.publisher.placeNetherlands-
dc.identifier.issnl2352-3964-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats