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Article: Age-specific genetic and antigenic variations of influenza A viruses in Hong Kong, 2013–2014
Title | Age-specific genetic and antigenic variations of influenza A viruses in Hong Kong, 2013–2014 |
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Authors | |
Issue Date | 2016 |
Publisher | Nature Publishing Group: Open Access Journals. The Journal's web site is located at http://www.nature.com/srep/index.html |
Citation | Scientific Reports, 2016, v. 6, p. article no. 30260 How to Cite? |
Abstract | Age-specific genetic and antigenic variations of influenza viruses have not been documented in tropical and subtropical regions. We implemented a systematic surveillance program in two tertiary hospitals in Hong Kong Island, to collect 112 A(H1N1)pdm09 and 254 A(H3N2) positive specimens from 2013 to 2014. Of these, 56 and 72 were identified as genetic variants of the WHO recommended vaccine composition strains, respectively. A subset of these genetic variants was selected for hemagglutination-inhibition (HI) tests, but none appeared to be antigenic variants of the vaccine composition strains. We also found that genetic and antigenicity variations were similar across sex and age groups of ≤18 yrs, 18 to 65 yrs, and ≥65 yrs. Our findings suggest that none of the age groups led other age groups in genetic evolution of influenza virus A strains. Future studies from different regions and longer study periods are needed to further investigate the age and sex heterogeneity of influenza viruses. |
Description | Altmetric: 2Views: 139More detail |
Persistent Identifier | http://hdl.handle.net/10722/230518 |
ISSN | 2023 Impact Factor: 3.8 2023 SCImago Journal Rankings: 0.900 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Cao, P | - |
dc.contributor.author | Wong, CM | - |
dc.contributor.author | Chan, KH | - |
dc.contributor.author | Wang, X | - |
dc.contributor.author | Chan, KP | - |
dc.contributor.author | Peiris, JSM | - |
dc.contributor.author | Poon, LML | - |
dc.contributor.author | Yang, L | - |
dc.date.accessioned | 2016-08-23T14:17:30Z | - |
dc.date.available | 2016-08-23T14:17:30Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Scientific Reports, 2016, v. 6, p. article no. 30260 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/10722/230518 | - |
dc.description | Altmetric: 2Views: 139More detail | - |
dc.description.abstract | Age-specific genetic and antigenic variations of influenza viruses have not been documented in tropical and subtropical regions. We implemented a systematic surveillance program in two tertiary hospitals in Hong Kong Island, to collect 112 A(H1N1)pdm09 and 254 A(H3N2) positive specimens from 2013 to 2014. Of these, 56 and 72 were identified as genetic variants of the WHO recommended vaccine composition strains, respectively. A subset of these genetic variants was selected for hemagglutination-inhibition (HI) tests, but none appeared to be antigenic variants of the vaccine composition strains. We also found that genetic and antigenicity variations were similar across sex and age groups of ≤18 yrs, 18 to 65 yrs, and ≥65 yrs. Our findings suggest that none of the age groups led other age groups in genetic evolution of influenza virus A strains. Future studies from different regions and longer study periods are needed to further investigate the age and sex heterogeneity of influenza viruses. | - |
dc.language | eng | - |
dc.publisher | Nature Publishing Group: Open Access Journals. The Journal's web site is located at http://www.nature.com/srep/index.html | - |
dc.relation.ispartof | Scientific Reports | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Age-specific genetic and antigenic variations of influenza A viruses in Hong Kong, 2013–2014 | - |
dc.type | Article | - |
dc.identifier.email | Wong, CM: hrmrwcm@hku.hk | - |
dc.identifier.email | Chan, KH: chankh2@hkucc.hku.hk | - |
dc.identifier.email | Chan, KP: kpchanaa@hku.hk | - |
dc.identifier.email | Peiris, JSM: malik@hkucc.hku.hk | - |
dc.identifier.email | Poon, LML: llmpoon@hkucc.hku.hk | - |
dc.identifier.authority | Wong, CM=rp00338 | - |
dc.identifier.authority | Chan, KH=rp01921 | - |
dc.identifier.authority | Peiris, JSM=rp00410 | - |
dc.identifier.authority | Poon, LML=rp00484 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/srep30260 | - |
dc.identifier.scopus | eid_2-s2.0-84979555858 | - |
dc.identifier.hkuros | 262397 | - |
dc.identifier.volume | 6 | - |
dc.identifier.spage | article no. 30260 | - |
dc.identifier.epage | article no. 30260 | - |
dc.identifier.isi | WOS:000380188100001 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 2045-2322 | - |