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Article: Age-specific genetic and antigenic variations of influenza A viruses in Hong Kong, 2013–2014

TitleAge-specific genetic and antigenic variations of influenza A viruses in Hong Kong, 2013–2014
Authors
Cao, PWong, CMChan, KHWang, XChan, KPPeiris, JSMPoon, LMLYang, L
Issue Date2016
PublisherNature Publishing Group: Open Access Journals. The Journal's web site is located at http://www.nature.com/srep/index.html
Citation
Scientific Reports, 2016, v. 6, p. article no. 30260 How to Cite?
DOI: http://dx.doi.org/10.1038/srep30260
AbstractAge-specific genetic and antigenic variations of influenza viruses have not been documented in tropical and subtropical regions. We implemented a systematic surveillance program in two tertiary hospitals in Hong Kong Island, to collect 112 A(H1N1)pdm09 and 254 A(H3N2) positive specimens from 2013 to 2014. Of these, 56 and 72 were identified as genetic variants of the WHO recommended vaccine composition strains, respectively. A subset of these genetic variants was selected for hemagglutination-inhibition (HI) tests, but none appeared to be antigenic variants of the vaccine composition strains. We also found that genetic and antigenicity variations were similar across sex and age groups of ≤18 yrs, 18 to 65 yrs, and ≥65 yrs. Our findings suggest that none of the age groups led other age groups in genetic evolution of influenza virus A strains. Future studies from different regions and longer study periods are needed to further investigate the age and sex heterogeneity of influenza viruses.
DescriptionAltmetric: 2Views: 139More detail
Persistent Identifierhttp://hdl.handle.net/10722/230518
ISSN
2045-2322
2021 Impact Factor: 4.996
2020 SCImago Journal Rankings: 1.240
ISI Accession Number ID
WOS:000380188100001

 

DC FieldValueLanguage
dc.contributor.authorCao, P-
dc.contributor.authorWong, CM-
dc.contributor.authorChan, KH-
dc.contributor.authorWang, X-
dc.contributor.authorChan, KP-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorPoon, LML-
dc.contributor.authorYang, L-
dc.date.accessioned2016-08-23T14:17:30Z-
dc.date.available2016-08-23T14:17:30Z-
dc.date.issued2016-
dc.identifier.citationScientific Reports, 2016, v. 6, p. article no. 30260-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10722/230518-
dc.descriptionAltmetric: 2Views: 139More detail-
dc.description.abstractAge-specific genetic and antigenic variations of influenza viruses have not been documented in tropical and subtropical regions. We implemented a systematic surveillance program in two tertiary hospitals in Hong Kong Island, to collect 112 A(H1N1)pdm09 and 254 A(H3N2) positive specimens from 2013 to 2014. Of these, 56 and 72 were identified as genetic variants of the WHO recommended vaccine composition strains, respectively. A subset of these genetic variants was selected for hemagglutination-inhibition (HI) tests, but none appeared to be antigenic variants of the vaccine composition strains. We also found that genetic and antigenicity variations were similar across sex and age groups of ≤18 yrs, 18 to 65 yrs, and ≥65 yrs. Our findings suggest that none of the age groups led other age groups in genetic evolution of influenza virus A strains. Future studies from different regions and longer study periods are needed to further investigate the age and sex heterogeneity of influenza viruses.-
dc.languageeng-
dc.publisherNature Publishing Group: Open Access Journals. The Journal's web site is located at http://www.nature.com/srep/index.html-
dc.relation.ispartofScientific Reports-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleAge-specific genetic and antigenic variations of influenza A viruses in Hong Kong, 2013–2014-
dc.typeArticle-
dc.identifier.emailWong, CM: hrmrwcm@hku.hk-
dc.identifier.emailChan, KH: chankh2@hkucc.hku.hk-
dc.identifier.emailChan, KP: kpchanaa@hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.emailPoon, LML: llmpoon@hkucc.hku.hk-
dc.identifier.authorityWong, CM=rp00338-
dc.identifier.authorityChan, KH=rp01921-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.identifier.authorityPoon, LML=rp00484-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/srep30260-
dc.identifier.scopuseid_2-s2.0-84979555858-
dc.identifier.hkuros262397-
dc.identifier.volume6-
dc.identifier.spagearticle no. 30260-
dc.identifier.epagearticle no. 30260-
dc.identifier.isiWOS:000380188100001-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl2045-2322-

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