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- Scopus: eid_2-s2.0-84868636737
- PMID: 23057155
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Article: Serum small-dense LDL abnormalities in chronic renal disease patients
Title | Serum small-dense LDL abnormalities in chronic renal disease patients |
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Authors | |
Keywords | Kidney diseases |
Issue Date | 2012 |
Citation | British Journal of Biomedical Science, 2012, v. 69, n. 3, p. 99-102 How to Cite? |
Abstract | Cardiovascular disease (CVD) is the principal cause of mortality in chronic kidney disease (CKD) patients. Dyslipoproteinaemia is a common metabolic derangement in CKD and a traditional risk factor for CVD. This study investigates serum lipoprotein, especially small-dense lowdensity lipoprotein (sd-LDL), abnormalities in CKD patients. A total of 131 CKD patients (age: 59±12 years, male=64) diagnosed according to Kidney Disease: Improving Global Outcomes, 2004 (KDIGO) and 121 ageand gender-matched control subjects (age: 58±6 years, male=62) were recruited from Hong Kong and Macau. Serum total cholesterol (TC), triglyceride (TG), highdensity lipoprotein-cholesterol (HDL-C) and direct LDL-C were assayed enzymatically. In addition, sd-LDL, together with very low density and intermediate-density lipoproteins (VLDL and IDL) were measured by US Food and Drug Administration (FDA)-approved polyacrylamide gradient gel electrophoresis. Compared to controls, CKD patients showed significantly decreased TC, LDL-C, normal-size LDL and HDL-C with increased TG, VLDL, IDL and sd-LDL (all P<0.01). The increased sd-LDL and decreased normal-size LDL fractions resulted in a significantly elevated sd-LDL:LDL ratio in CKD (P<0.005). In contrast to the low TC and LDL-C, sd-LDL and sd- LDL:LDL ratio were significantly elevated in CKD. Thus, sd-LDL will be used increasingly for CVD risk assessment in CKD and other diseases that show lipoprotein derangement. |
Persistent Identifier | http://hdl.handle.net/10722/228470 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.498 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chu, M. | - |
dc.contributor.author | Wang, A. Y M | - |
dc.contributor.author | Chan, I. H S | - |
dc.contributor.author | Chui, S. H. | - |
dc.contributor.author | Lam, C. W K | - |
dc.date.accessioned | 2016-08-13T08:02:29Z | - |
dc.date.available | 2016-08-13T08:02:29Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | British Journal of Biomedical Science, 2012, v. 69, n. 3, p. 99-102 | - |
dc.identifier.issn | 0967-4845 | - |
dc.identifier.uri | http://hdl.handle.net/10722/228470 | - |
dc.description.abstract | Cardiovascular disease (CVD) is the principal cause of mortality in chronic kidney disease (CKD) patients. Dyslipoproteinaemia is a common metabolic derangement in CKD and a traditional risk factor for CVD. This study investigates serum lipoprotein, especially small-dense lowdensity lipoprotein (sd-LDL), abnormalities in CKD patients. A total of 131 CKD patients (age: 59±12 years, male=64) diagnosed according to Kidney Disease: Improving Global Outcomes, 2004 (KDIGO) and 121 ageand gender-matched control subjects (age: 58±6 years, male=62) were recruited from Hong Kong and Macau. Serum total cholesterol (TC), triglyceride (TG), highdensity lipoprotein-cholesterol (HDL-C) and direct LDL-C were assayed enzymatically. In addition, sd-LDL, together with very low density and intermediate-density lipoproteins (VLDL and IDL) were measured by US Food and Drug Administration (FDA)-approved polyacrylamide gradient gel electrophoresis. Compared to controls, CKD patients showed significantly decreased TC, LDL-C, normal-size LDL and HDL-C with increased TG, VLDL, IDL and sd-LDL (all P<0.01). The increased sd-LDL and decreased normal-size LDL fractions resulted in a significantly elevated sd-LDL:LDL ratio in CKD (P<0.005). In contrast to the low TC and LDL-C, sd-LDL and sd- LDL:LDL ratio were significantly elevated in CKD. Thus, sd-LDL will be used increasingly for CVD risk assessment in CKD and other diseases that show lipoprotein derangement. | - |
dc.language | eng | - |
dc.relation.ispartof | British Journal of Biomedical Science | - |
dc.subject | Kidney diseases | - |
dc.title | Serum small-dense LDL abnormalities in chronic renal disease patients | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.pmid | 23057155 | - |
dc.identifier.scopus | eid_2-s2.0-84868636737 | - |
dc.identifier.volume | 69 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 99 | - |
dc.identifier.epage | 102 | - |
dc.identifier.isi | WOS:000308785700002 | - |
dc.identifier.issnl | 0967-4845 | - |