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Conference Paper: Age-related Differences In Metabolites In The Anterior And Posterior Cingulate Cortices Of The Aging Brain

TitleAge-related Differences In Metabolites In The Anterior And Posterior Cingulate Cortices Of The Aging Brain
Authors
Issue Date2016
PublisherScience of Learning Strategic Research Theme (SoL-SRT), The University of Hong Kong.
Citation
SummerFest 2016: Impact, Innovation and Integrity, The University of Hong Kong, Hong Kong, 20-22 July 2016 How to Cite?
AbstractAging of the human brain is the common predisposing factor of neurodegenerative diseases. It is the primary risk factor for Alzheimer’s disease and other prevalent neurodegenerative disorders. Proton magnetic resonance spectroscopy (1H-MRS) is a non-invasive clinical tool which can measure in vivo metabolite levels by using proton signals from the metabolites. N-acetyl-aspartate (NAA) and Glx [summation of glutamate (Glu) and glutamine (Gln)] are examples of metabolites which can be measured and quantified by 1H-MRS. NAA is a well-known marker specific for mature neurons. Glx, which has an interesting role in aging, could be used as a central measure for glutamatergic neurotransmission by assessing the entire brain pool of Glu and Gln. Both NAA and Glx have been suggested for measures of energy metabolism, and can serve as neurochemical fingerprints of neural activites in the brain. As the anterior cingulate cortex has recently become a focus for aging research because of its implicated role in attention and mood regulation, we evaluated any changes in neural tissue composition with aging, as measured by absolute quantification of metabolites such as choline, creatine, NAA, Glx, and myo-inositol using 1H-MRS at 3 T. The findings and future directions will be discussed from various perspectives.
DescriptionSymposium: New Methods in MRI Technology: Talk 3
Persistent Identifierhttp://hdl.handle.net/10722/228365

 

DC FieldValueLanguage
dc.contributor.authorChiu, PW-
dc.date.accessioned2016-08-11T07:09:47Z-
dc.date.available2016-08-11T07:09:47Z-
dc.date.issued2016-
dc.identifier.citationSummerFest 2016: Impact, Innovation and Integrity, The University of Hong Kong, Hong Kong, 20-22 July 2016-
dc.identifier.urihttp://hdl.handle.net/10722/228365-
dc.descriptionSymposium: New Methods in MRI Technology: Talk 3-
dc.description.abstractAging of the human brain is the common predisposing factor of neurodegenerative diseases. It is the primary risk factor for Alzheimer’s disease and other prevalent neurodegenerative disorders. Proton magnetic resonance spectroscopy (1H-MRS) is a non-invasive clinical tool which can measure in vivo metabolite levels by using proton signals from the metabolites. N-acetyl-aspartate (NAA) and Glx [summation of glutamate (Glu) and glutamine (Gln)] are examples of metabolites which can be measured and quantified by 1H-MRS. NAA is a well-known marker specific for mature neurons. Glx, which has an interesting role in aging, could be used as a central measure for glutamatergic neurotransmission by assessing the entire brain pool of Glu and Gln. Both NAA and Glx have been suggested for measures of energy metabolism, and can serve as neurochemical fingerprints of neural activites in the brain. As the anterior cingulate cortex has recently become a focus for aging research because of its implicated role in attention and mood regulation, we evaluated any changes in neural tissue composition with aging, as measured by absolute quantification of metabolites such as choline, creatine, NAA, Glx, and myo-inositol using 1H-MRS at 3 T. The findings and future directions will be discussed from various perspectives.-
dc.languageeng-
dc.publisherScience of Learning Strategic Research Theme (SoL-SRT), The University of Hong Kong. -
dc.relation.ispartofSummerFest 2016-
dc.titleAge-related Differences In Metabolites In The Anterior And Posterior Cingulate Cortices Of The Aging Brain-
dc.typeConference_Paper-
dc.identifier.emailChiu, PW: pwcchiu@hku.hk-
dc.identifier.hkuros260762-
dc.publisher.placeHong Kong-

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