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- Publisher Website: 10.1167/iovs.05-0178
- Scopus: eid_2-s2.0-33644687069
- PMID: 16249487
- WOS: WOS:000232807400024
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Article: Color visual evoked potentials in children with type 1 diabetes: Relationship to metabolic control
Title | Color visual evoked potentials in children with type 1 diabetes: Relationship to metabolic control |
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Authors | |
Issue Date | 2005 |
Citation | Investigative Ophthalmology and Visual Science, 2005, v. 46, n. 11, p. 4107-4113 How to Cite? |
Abstract | PURPOSE. To examine the association between metabolic control (HbA 1c) and the chromatic mechanisms of children with type 1 diabetes (T1D), by using the color visual evoked potential (VEP). METHODS. Fifty children with T1D (age range, 6-12.9 years) and 33 age-matched control subjects were tested. VEPs were recorded by placing five electrodes on the scalp according to the International 10/20 System of Electrode Placement. Active electrodes O1, O2, and Oz were placed over the visual cortex. Short-wavelength (S), and long- and medium-wavelength (LM) color stimuli consisted of vertical, photometric isoluminant (1 cyc/deg) gratings presented in a pattern onset (100 ms)- offset (400 ms) mode. Achromatic vertical gratings were presented at 3 cyc/deg. Primary outcome measure was VEP latency. The relationship between S, LM, and achromatic VEP latency, and HbA1c was determined by ANCOVA regression. RESULTS. S-, LM-, achromatic VEP latencies were not associated significantly with HbA1c. Pubertal status, however, was associated significantly (P = 0.0114) and selectively with S-VEP latency. Pubertal children with T1D had delayed (mean delay, 9.5 ms) S-VEP latencies when compared with the prepubertal children with T1D. However, there was no statistically significant difference (P = 0.1573) in the effect of pubertal status on S-VEP latency between the T1D and control groups. CONCLUSIONS. Pubertal status rather than HbA1c appears to affect selectively the S-VEP latency of preteen children with T1D. Further study is warranted to determine whether the delay in S-VEP latency in pubertal children with T1D changes over time and whether this change could be a predictive marker for future development of background diabetic retinopathy. Copyright © Association for Research in Vision and Ophthalmology. |
Persistent Identifier | http://hdl.handle.net/10722/228037 |
ISSN | 2023 Impact Factor: 5.0 2023 SCImago Journal Rankings: 1.422 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Elia, Yesmino T. | - |
dc.contributor.author | Daneman, Denis | - |
dc.contributor.author | Rovet, Joanne | - |
dc.contributor.author | Abdolell, Mohamed | - |
dc.contributor.author | Lam, Wai Ching | - |
dc.contributor.author | Till, Christine | - |
dc.contributor.author | Erraguntla, Vasudha | - |
dc.contributor.author | Rubab, Shehla | - |
dc.contributor.author | Lodha, Nidhi | - |
dc.contributor.author | Westall, Carol A. | - |
dc.date.accessioned | 2016-08-01T06:45:02Z | - |
dc.date.available | 2016-08-01T06:45:02Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Investigative Ophthalmology and Visual Science, 2005, v. 46, n. 11, p. 4107-4113 | - |
dc.identifier.issn | 0146-0404 | - |
dc.identifier.uri | http://hdl.handle.net/10722/228037 | - |
dc.description.abstract | PURPOSE. To examine the association between metabolic control (HbA 1c) and the chromatic mechanisms of children with type 1 diabetes (T1D), by using the color visual evoked potential (VEP). METHODS. Fifty children with T1D (age range, 6-12.9 years) and 33 age-matched control subjects were tested. VEPs were recorded by placing five electrodes on the scalp according to the International 10/20 System of Electrode Placement. Active electrodes O1, O2, and Oz were placed over the visual cortex. Short-wavelength (S), and long- and medium-wavelength (LM) color stimuli consisted of vertical, photometric isoluminant (1 cyc/deg) gratings presented in a pattern onset (100 ms)- offset (400 ms) mode. Achromatic vertical gratings were presented at 3 cyc/deg. Primary outcome measure was VEP latency. The relationship between S, LM, and achromatic VEP latency, and HbA1c was determined by ANCOVA regression. RESULTS. S-, LM-, achromatic VEP latencies were not associated significantly with HbA1c. Pubertal status, however, was associated significantly (P = 0.0114) and selectively with S-VEP latency. Pubertal children with T1D had delayed (mean delay, 9.5 ms) S-VEP latencies when compared with the prepubertal children with T1D. However, there was no statistically significant difference (P = 0.1573) in the effect of pubertal status on S-VEP latency between the T1D and control groups. CONCLUSIONS. Pubertal status rather than HbA1c appears to affect selectively the S-VEP latency of preteen children with T1D. Further study is warranted to determine whether the delay in S-VEP latency in pubertal children with T1D changes over time and whether this change could be a predictive marker for future development of background diabetic retinopathy. Copyright © Association for Research in Vision and Ophthalmology. | - |
dc.language | eng | - |
dc.relation.ispartof | Investigative Ophthalmology and Visual Science | - |
dc.title | Color visual evoked potentials in children with type 1 diabetes: Relationship to metabolic control | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1167/iovs.05-0178 | - |
dc.identifier.pmid | 16249487 | - |
dc.identifier.scopus | eid_2-s2.0-33644687069 | - |
dc.identifier.volume | 46 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 4107 | - |
dc.identifier.epage | 4113 | - |
dc.identifier.isi | WOS:000232807400024 | - |
dc.identifier.issnl | 0146-0404 | - |