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Article: Ivabradine in Severe Aortic Stenosis with Poor Left Ventricular Ejection Fraction
Title | Ivabradine in Severe Aortic Stenosis with Poor Left Ventricular Ejection Fraction |
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Authors | |
Issue Date | 2015 |
Publisher | ICR Publishers Ltd. The Journal's web site is located at http://www.icr-heart.com/ |
Citation | The Journal of Heart Value Disease, 2015, v. 24 n. 4, p. 433-435 How to Cite? |
Abstract | Patients with severe aortic stenosis (AS) and left ventricular systolic dysfunction pose a significant challenge to the managing physician. Conventional pharmacological therapy for systolic heart failure has not been proven beneficial in this setting. Ivabradine, a selective current inhibitor, decreases the spontaneous firing rate of sinoatrial nodal cells, thereby reducing the heart rate, and has been shown to reduce a composite end-point of heart failure hospitalization and mortality in patients with impaired left ventricular function. Herein are reported details of the hemodynamic effects and clinical outcome of ivabradine treatment in an 86-year-old man with severe AS and severe left ventricular systolic function. |
Persistent Identifier | http://hdl.handle.net/10722/227379 |
ISSN | 2015 Impact Factor: 0.715 2020 SCImago Journal Rankings: 0.286 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Huang, D | - |
dc.contributor.author | Chan, PHM | - |
dc.contributor.author | Lam, CC | - |
dc.contributor.author | Shea, PC | - |
dc.contributor.author | Yiu, KH | - |
dc.contributor.author | Tse, HF | - |
dc.contributor.author | Siu, DCW | - |
dc.date.accessioned | 2016-07-18T09:10:08Z | - |
dc.date.available | 2016-07-18T09:10:08Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | The Journal of Heart Value Disease, 2015, v. 24 n. 4, p. 433-435 | - |
dc.identifier.issn | 0966-8519 | - |
dc.identifier.uri | http://hdl.handle.net/10722/227379 | - |
dc.description.abstract | Patients with severe aortic stenosis (AS) and left ventricular systolic dysfunction pose a significant challenge to the managing physician. Conventional pharmacological therapy for systolic heart failure has not been proven beneficial in this setting. Ivabradine, a selective current inhibitor, decreases the spontaneous firing rate of sinoatrial nodal cells, thereby reducing the heart rate, and has been shown to reduce a composite end-point of heart failure hospitalization and mortality in patients with impaired left ventricular function. Herein are reported details of the hemodynamic effects and clinical outcome of ivabradine treatment in an 86-year-old man with severe AS and severe left ventricular systolic function. | - |
dc.language | eng | - |
dc.publisher | ICR Publishers Ltd. The Journal's web site is located at http://www.icr-heart.com/ | - |
dc.relation.ispartof | The Journal of Heart Value Disease | - |
dc.title | Ivabradine in Severe Aortic Stenosis with Poor Left Ventricular Ejection Fraction | - |
dc.type | Article | - |
dc.identifier.email | Chan, PHM: phmchan@hku.hk | - |
dc.identifier.email | Yiu, KH: khkyiu@hku.hk | - |
dc.identifier.email | Tse, HF: hftse@hkucc.hku.hk | - |
dc.identifier.email | Siu, DCW: cwdsiu@hkucc.hku.hk | - |
dc.identifier.authority | Chan, PHM=rp01864 | - |
dc.identifier.authority | Yiu, KH=rp01490 | - |
dc.identifier.authority | Tse, HF=rp00428 | - |
dc.identifier.authority | Siu, DCW=rp00534 | - |
dc.identifier.pmid | 26897811 | - |
dc.identifier.hkuros | 259697 | - |
dc.identifier.volume | 24 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 433 | - |
dc.identifier.epage | 435 | - |
dc.identifier.isi | WOS:000369045700005 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0966-8519 | - |