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- Publisher Website: 10.1016/S0531-5565(00)00187-X
- Scopus: eid_2-s2.0-0035192848
- PMID: 11162913
- WOS: WOS:000166432300007
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Article: Estimation of replicative senescence via a population dynamics model of cells in culture
Title | Estimation of replicative senescence via a population dynamics model of cells in culture |
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Authors | |
Keywords | Replicative senescence Mathematical model Stochastic processes |
Issue Date | 2001 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/expgero |
Citation | Experimental Gerontology, 2001, v. 36 n. 1, p. 79-88 How to Cite? |
Abstract | A simple mathematical model is developed for determining the time-varying fraction of senescent cells in culture in terms of the underlying probability distribution of the number of population doublings until senescence. This functional relationship is inverted, which allows for the estimation of the probability distribution of the number of population doublings until senescence given experimental data on the time-varying fraction of senescent cells. The relationship - in particular, the lag - between these two quantities is analyzed under the assumption that the number of population doublings until senescence follows the Weibull distribution. If the number of population doublings until senescence is geometrically distributed (i.e. the Weibull with shape parameter equal to one) then the cell culture appears immortal. |
Persistent Identifier | http://hdl.handle.net/10722/226853 |
ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 1.051 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wein, LM | - |
dc.contributor.author | Wu, JTK | - |
dc.date.accessioned | 2016-07-07T04:22:57Z | - |
dc.date.available | 2016-07-07T04:22:57Z | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Experimental Gerontology, 2001, v. 36 n. 1, p. 79-88 | - |
dc.identifier.issn | 0531-5565 | - |
dc.identifier.uri | http://hdl.handle.net/10722/226853 | - |
dc.description.abstract | A simple mathematical model is developed for determining the time-varying fraction of senescent cells in culture in terms of the underlying probability distribution of the number of population doublings until senescence. This functional relationship is inverted, which allows for the estimation of the probability distribution of the number of population doublings until senescence given experimental data on the time-varying fraction of senescent cells. The relationship - in particular, the lag - between these two quantities is analyzed under the assumption that the number of population doublings until senescence follows the Weibull distribution. If the number of population doublings until senescence is geometrically distributed (i.e. the Weibull with shape parameter equal to one) then the cell culture appears immortal. | - |
dc.language | eng | - |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/expgero | - |
dc.relation.ispartof | Experimental Gerontology | - |
dc.rights | Posting accepted manuscript (postprint): © <2001>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | Replicative senescence | - |
dc.subject | Mathematical model | - |
dc.subject | Stochastic processes | - |
dc.title | Estimation of replicative senescence via a population dynamics model of cells in culture | - |
dc.type | Article | - |
dc.identifier.email | Wu, JTK: joewu@hkucc.hku.hk | - |
dc.identifier.authority | Wu, JTK=rp00517 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/S0531-5565(00)00187-X | - |
dc.identifier.pmid | 11162913 | - |
dc.identifier.scopus | eid_2-s2.0-0035192848 | - |
dc.identifier.volume | 36 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 79 | - |
dc.identifier.epage | 88 | - |
dc.identifier.isi | WOS:000166432300007 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0531-5565 | - |