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Article: Surgery for scoliosis in Duchenne muscular dystrophy

TitleSurgery for scoliosis in Duchenne muscular dystrophy
Authors
Issue Date2015
PublisherWiley for Cochrane Collaboration. The Journal's web site is located at http://www.wiley.com/WileyCDA/Brand/id-6.html?category=For+Working
Citation
Cochrane Database of Systematic Reviews, 2015, n. 10, article no. CD005375 How to Cite?
AbstractBackground: Scoliosis in patients with Duchenne muscular dystrophy (DMD) is usually progressive and is treated with surgery. However, it is unclear whether the existing evidence is sufficiently scientifically rigorous to support a recommendation for spinal surgery for most patients with DMD and scoliosis. This is an updated review, and an updated search was undertaken in which no new studies were found for inclusion. Objectives: To determine the effectiveness and safety of spinal surgery in patients with DMD with scoliosis. We intended to test whether spinal surgery is effective in increasing survival and improving respiratory function, quality of life, and overall functioning, and whether spinal surgery is associated with severe adverse effects. Search methods: On 16 June 2015 we searched the Cochrane Neuromuscular Disease Group Specialized Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, and CINAHL Plus. We also searched ProQuest Dissertation and Thesis database (January 1980 to June 2015), the National Institutes of Health Clinical Trials Database (6 January 2015), and the WHO International Clinical Trials Registry Platform (17 June 2015), and checked references. We imposed no language restrictions. Selection criteria: We planned to include controlled clinical trials using random or quasi-random allocation of treatment evaluating all forms of spinal surgery for scoliosis in patients with DMD in the review. The control interventions would have been no treatment, non-operative treatment, or a different form of spinal surgery. Data collection and analysis: We used standard methodological procedures expected by The Cochrane Collaboration. Two review authors independently examined the search results and evaluated the study characteristics against inclusion criteria in order to decide which studies to include in the review. Main results: Of the 49 relevant studies we found, none met the inclusion criteria for the review because they were not clinical trials, but prospective or retrospective reviews of case series. Authors' conclusions: Since no randomized controlled clinical trials were available to evaluate the effectiveness of scoliosis surgery in patients with DMD, we can make no good evidence-based conclusion to guide clinical practice. Patients with scoliosis should be informed as to the uncertainty of benefits and potential risks of surgery for scoliosis. Randomized controlled trials are needed to investigate the effectiveness of scoliosis surgery, in terms of quality of life, functional status, respiratory function, and life expectancy.
Persistent Identifierhttp://hdl.handle.net/10722/226376
ISSN
2023 Impact Factor: 8.8
2020 SCImago Journal Rankings: 1.319
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheuk, KLD-
dc.contributor.authorWong, VCN-
dc.contributor.authorWraige, E-
dc.contributor.authorBaxter, P-
dc.contributor.authorCole, A-
dc.date.accessioned2016-06-17T07:43:44Z-
dc.date.available2016-06-17T07:43:44Z-
dc.date.issued2015-
dc.identifier.citationCochrane Database of Systematic Reviews, 2015, n. 10, article no. CD005375-
dc.identifier.issn1469-493X-
dc.identifier.urihttp://hdl.handle.net/10722/226376-
dc.description.abstractBackground: Scoliosis in patients with Duchenne muscular dystrophy (DMD) is usually progressive and is treated with surgery. However, it is unclear whether the existing evidence is sufficiently scientifically rigorous to support a recommendation for spinal surgery for most patients with DMD and scoliosis. This is an updated review, and an updated search was undertaken in which no new studies were found for inclusion. Objectives: To determine the effectiveness and safety of spinal surgery in patients with DMD with scoliosis. We intended to test whether spinal surgery is effective in increasing survival and improving respiratory function, quality of life, and overall functioning, and whether spinal surgery is associated with severe adverse effects. Search methods: On 16 June 2015 we searched the Cochrane Neuromuscular Disease Group Specialized Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, and CINAHL Plus. We also searched ProQuest Dissertation and Thesis database (January 1980 to June 2015), the National Institutes of Health Clinical Trials Database (6 January 2015), and the WHO International Clinical Trials Registry Platform (17 June 2015), and checked references. We imposed no language restrictions. Selection criteria: We planned to include controlled clinical trials using random or quasi-random allocation of treatment evaluating all forms of spinal surgery for scoliosis in patients with DMD in the review. The control interventions would have been no treatment, non-operative treatment, or a different form of spinal surgery. Data collection and analysis: We used standard methodological procedures expected by The Cochrane Collaboration. Two review authors independently examined the search results and evaluated the study characteristics against inclusion criteria in order to decide which studies to include in the review. Main results: Of the 49 relevant studies we found, none met the inclusion criteria for the review because they were not clinical trials, but prospective or retrospective reviews of case series. Authors' conclusions: Since no randomized controlled clinical trials were available to evaluate the effectiveness of scoliosis surgery in patients with DMD, we can make no good evidence-based conclusion to guide clinical practice. Patients with scoliosis should be informed as to the uncertainty of benefits and potential risks of surgery for scoliosis. Randomized controlled trials are needed to investigate the effectiveness of scoliosis surgery, in terms of quality of life, functional status, respiratory function, and life expectancy.-
dc.languageeng-
dc.publisherWiley for Cochrane Collaboration. The Journal's web site is located at http://www.wiley.com/WileyCDA/Brand/id-6.html?category=For+Working-
dc.relation.ispartofCochrane Database of Systematic Reviews-
dc.rightsThis review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 2015, Issue 10. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.-
dc.titleSurgery for scoliosis in Duchenne muscular dystrophy-
dc.typeArticle-
dc.identifier.emailCheuk, KLD: klcheuk@hkucc.hku.hk-
dc.identifier.emailWong, VCN: vcnwong@hku.hk-
dc.identifier.authorityWong, VCN=rp00334-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1002/14651858.CD005375.pub4-
dc.identifier.pmid26423318-
dc.identifier.pmcidPMC7273403-
dc.identifier.scopuseid_2-s2.0-84979850692-
dc.identifier.hkuros258699-
dc.identifier.issue10-
dc.identifier.spagearticle no. CD005375-
dc.identifier.epagearticle no. CD005375-
dc.identifier.isiWOS:000366060300018-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1361-6137-

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