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- Publisher Website: 10.1016/S0168-8278(95)80001-8
- Scopus: eid_2-s2.0-0029153216
- PMID: 8550986
- WOS: WOS:A1995RT62000001
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Article: Acute sporadic hepatitis E virus infection in southern China
Title | Acute sporadic hepatitis E virus infection in southern China |
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Authors | |
Keywords | HEV IgG and IgM anti-HEV Non-A,B, C, D, E hepatitis |
Issue Date | 1995 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep |
Citation | Journal of Hepatology, 1995, v. 23 n. 3, p. 239-245 How to Cite? |
Abstract | BACKGROUND/AIMS: The hepatitis E virus is responsible for epidemic and sporadic hepatitis in northwestern China, but its role as a cause of acute sporadic hepatitis in southern China has not been reported. METHODS: We applied the most practical current methods for diagnosis of hepatitis E virus infection, IgM and IgG anti-HEV detection by enzyme linked immunosorbent assay, to investigate the prevalence of hepatitis E virus infection among acute sporadic hepatitis. RESULTS: Anti-HEV IgM was found in 1 of 26 (3.8%), 4 of 20 (20.0%), 4 of 19 (21.1%), and 51 of 142 (35.9%), with acute hepatitis A, B, C and non-ABC, respectively. Anti-HEV IgM was not detectable in healthy subjects, while IgG anti-HEV was found in 14 of 77 healthy subjects (18.2%) and was long-lasting. Ninety-one cases without any evidence of hepatitis A, B or C infections and anti-HEV IgM were tentatively classified as non-A, B, C, D, E (non-ABCDE) hepatitis. By comparison with non-ABCDE, cases with hepatitis E were more frequently icteric and exhibited higher alanine aminotransferase levels (92.2% vs. 45.1%, 770 iu/l vs 377 iu/l, respectively, p < 0.005). Chronic cases were not observed in hepatitis E virus infections. However, 14 of 91 (15.4%) cases with non-ABCDE developed to chronicity (p < 0.005). CONCLUSIONS: Hepatitis E virus infection is sporadic as well as endemic in southern China. Only IgM anti-HEV but not IgG anti-HEV can be used as an appropriate marker of acute hepatitis E virus infection. Superinfection of hepatitis E virus with other types of hepatitis viruses is frequent in this area. While the disease was associated with more severe clinical manifestations, patients usually recovered completely. |
Persistent Identifier | http://hdl.handle.net/10722/225160 |
ISSN | 2023 Impact Factor: 26.8 2023 SCImago Journal Rankings: 9.857 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Tan, D | - |
dc.contributor.author | Im, SWK | - |
dc.contributor.author | Yao, JL | - |
dc.contributor.author | Ng, MH | - |
dc.date.accessioned | 2016-04-26T03:07:50Z | - |
dc.date.available | 2016-04-26T03:07:50Z | - |
dc.date.issued | 1995 | - |
dc.identifier.citation | Journal of Hepatology, 1995, v. 23 n. 3, p. 239-245 | - |
dc.identifier.issn | 0168-8278 | - |
dc.identifier.uri | http://hdl.handle.net/10722/225160 | - |
dc.description.abstract | BACKGROUND/AIMS: The hepatitis E virus is responsible for epidemic and sporadic hepatitis in northwestern China, but its role as a cause of acute sporadic hepatitis in southern China has not been reported. METHODS: We applied the most practical current methods for diagnosis of hepatitis E virus infection, IgM and IgG anti-HEV detection by enzyme linked immunosorbent assay, to investigate the prevalence of hepatitis E virus infection among acute sporadic hepatitis. RESULTS: Anti-HEV IgM was found in 1 of 26 (3.8%), 4 of 20 (20.0%), 4 of 19 (21.1%), and 51 of 142 (35.9%), with acute hepatitis A, B, C and non-ABC, respectively. Anti-HEV IgM was not detectable in healthy subjects, while IgG anti-HEV was found in 14 of 77 healthy subjects (18.2%) and was long-lasting. Ninety-one cases without any evidence of hepatitis A, B or C infections and anti-HEV IgM were tentatively classified as non-A, B, C, D, E (non-ABCDE) hepatitis. By comparison with non-ABCDE, cases with hepatitis E were more frequently icteric and exhibited higher alanine aminotransferase levels (92.2% vs. 45.1%, 770 iu/l vs 377 iu/l, respectively, p < 0.005). Chronic cases were not observed in hepatitis E virus infections. However, 14 of 91 (15.4%) cases with non-ABCDE developed to chronicity (p < 0.005). CONCLUSIONS: Hepatitis E virus infection is sporadic as well as endemic in southern China. Only IgM anti-HEV but not IgG anti-HEV can be used as an appropriate marker of acute hepatitis E virus infection. Superinfection of hepatitis E virus with other types of hepatitis viruses is frequent in this area. While the disease was associated with more severe clinical manifestations, patients usually recovered completely. | - |
dc.language | eng | - |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep | - |
dc.relation.ispartof | Journal of Hepatology | - |
dc.subject | HEV | - |
dc.subject | IgG and IgM anti-HEV | - |
dc.subject | Non-A,B, C, D, E hepatitis | - |
dc.subject.mesh | Hepatitis e - epidemiology - immunology | - |
dc.subject.mesh | Enzyme-linked immunosorbent assay | - |
dc.subject.mesh | Alanine transaminase - blood | - |
dc.subject.mesh | China - epidemiology | - |
dc.subject.mesh | Acute disease | - |
dc.title | Acute sporadic hepatitis E virus infection in southern China | - |
dc.type | Article | - |
dc.identifier.email | Im, SWK: swkim@hkucc.hku.hk | - |
dc.identifier.email | Ng, MH: hrmmnmh@hkucc.hku.hk | - |
dc.identifier.doi | 10.1016/S0168-8278(95)80001-8 | - |
dc.identifier.pmid | 8550986 | - |
dc.identifier.scopus | eid_2-s2.0-0029153216 | - |
dc.identifier.hkuros | 4371 | - |
dc.identifier.volume | 23 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 239 | - |
dc.identifier.epage | 245 | - |
dc.identifier.isi | WOS:A1995RT62000001 | - |
dc.publisher.place | Netherlands | - |
dc.identifier.issnl | 0168-8278 | - |