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Article: A stochastic model of fragment formation when DNA replicates
| Title | A stochastic model of fragment formation when DNA replicates |
|---|---|
| Authors | |
| Keywords | DNA replication Renewal equation Okazaki fragment |
| Issue Date | 1994 |
| Publisher | Applied Probability Trust. The Journal's web site is located at http://www.shef.ac.uk/uni/companies/apt/ap.html |
| Citation | Journal of Applied Probability, 1994, v. 31 n. 2, p. 301-308 How to Cite? |
| Abstract | The double-stranded molecule, DNA, has the unique property of replication and, because of this, it is the central molecule of life. The mechanism of replication for each single strand is intricate, involving enzymes which move along each of the single strands building a complementary copy. At the frontier of this action, the events have a strong stochastic character due to the random location on the DNA of key 'sites' where copying commences. A model of this process is analysed. The central problem of interest is the mean length of certain 'islands' of newly replicated DNA developed at the randomly located 'sites'. These islands, which have been observed experimentally, are called Okazaki fragments. |
| Persistent Identifier | http://hdl.handle.net/10722/225140 |
| ISSN | 2023 Impact Factor: 0.7 2023 SCImago Journal Rankings: 0.551 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Cowan, R | - |
| dc.contributor.author | Chiu, SN | - |
| dc.date.accessioned | 2016-04-22T06:43:37Z | - |
| dc.date.available | 2016-04-22T06:43:37Z | - |
| dc.date.issued | 1994 | - |
| dc.identifier.citation | Journal of Applied Probability, 1994, v. 31 n. 2, p. 301-308 | - |
| dc.identifier.issn | 0021-9002 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/225140 | - |
| dc.description.abstract | The double-stranded molecule, DNA, has the unique property of replication and, because of this, it is the central molecule of life. The mechanism of replication for each single strand is intricate, involving enzymes which move along each of the single strands building a complementary copy. At the frontier of this action, the events have a strong stochastic character due to the random location on the DNA of key 'sites' where copying commences. A model of this process is analysed. The central problem of interest is the mean length of certain 'islands' of newly replicated DNA developed at the randomly located 'sites'. These islands, which have been observed experimentally, are called Okazaki fragments. | - |
| dc.language | eng | - |
| dc.publisher | Applied Probability Trust. The Journal's web site is located at http://www.shef.ac.uk/uni/companies/apt/ap.html | - |
| dc.relation.ispartof | Journal of Applied Probability | - |
| dc.rights | Journal of Applied Probability. Copyright © Applied Probability Trust. | - |
| dc.subject | DNA replication | - |
| dc.subject | Renewal equation | - |
| dc.subject | Okazaki fragment | - |
| dc.title | A stochastic model of fragment formation when DNA replicates | - |
| dc.type | Article | - |
| dc.identifier.email | Cowan, R: rcowan@hkursc.hku.hk | - |
| dc.identifier.hkuros | 3941 | - |
| dc.identifier.volume | 31 | - |
| dc.identifier.issue | 2 | - |
| dc.identifier.spage | 301 | - |
| dc.identifier.epage | 308 | - |
| dc.publisher.place | United Kingdom | - |
| dc.identifier.issnl | 0021-9002 | - |