File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1515/revneuro-2011-0066
- Scopus: eid_2-s2.0-84861051747
- PMID: 22499674
- WOS: WOS:000304248400004
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Phosphoinositide 3-kinase enhancer (PIKE) in the brain: Is it simply a phosphoinositide 3-kinase/Akt enhancer?
Title | Phosphoinositide 3-kinase enhancer (PIKE) in the brain: Is it simply a phosphoinositide 3-kinase/Akt enhancer? |
---|---|
Authors | |
Keywords | GTPase Akt PIKE PI3K neuron |
Issue Date | 2012 |
Citation | Reviews in the Neurosciences, 2012, v. 23, n. 2, p. 153-161 How to Cite? |
Abstract | Since its discovery in 2000, phosphoinositide 3-kinase enhancer (PIKE) has been recognized as a class of GTPase that controls the enzymatic activities of phosphoinositide 3-kinase (PI3K) and Akt in the central nervous system (CNS). However, recent studies suggest that PIKEs are not only enhancers to PI3K/Akt but also modulators to other kinases including insulin receptor tyrosine kinase and focal adhesion kinases. Moreover, they regulate transcription factors such as signal transducer and activator of transcription and nuclear factor κB. Indeed, PIKE proteins participate in multiple cellular processes including control of cell survival, brain development, memory formation, gene transcription, and metabolism. In this review, we have summarized the functions of PIKE proteins in CNS and discussed their potential implications in various neurological disorders. © 2012 by Walter de Gruyter Berlin Boston. |
Persistent Identifier | http://hdl.handle.net/10722/225034 |
ISSN | 2023 Impact Factor: 3.4 2023 SCImago Journal Rankings: 1.108 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chan, Chi Bun | - |
dc.contributor.author | Ye, Keqiang | - |
dc.date.accessioned | 2016-04-18T11:16:34Z | - |
dc.date.available | 2016-04-18T11:16:34Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Reviews in the Neurosciences, 2012, v. 23, n. 2, p. 153-161 | - |
dc.identifier.issn | 0334-1763 | - |
dc.identifier.uri | http://hdl.handle.net/10722/225034 | - |
dc.description.abstract | Since its discovery in 2000, phosphoinositide 3-kinase enhancer (PIKE) has been recognized as a class of GTPase that controls the enzymatic activities of phosphoinositide 3-kinase (PI3K) and Akt in the central nervous system (CNS). However, recent studies suggest that PIKEs are not only enhancers to PI3K/Akt but also modulators to other kinases including insulin receptor tyrosine kinase and focal adhesion kinases. Moreover, they regulate transcription factors such as signal transducer and activator of transcription and nuclear factor κB. Indeed, PIKE proteins participate in multiple cellular processes including control of cell survival, brain development, memory formation, gene transcription, and metabolism. In this review, we have summarized the functions of PIKE proteins in CNS and discussed their potential implications in various neurological disorders. © 2012 by Walter de Gruyter Berlin Boston. | - |
dc.language | eng | - |
dc.relation.ispartof | Reviews in the Neurosciences | - |
dc.subject | GTPase | - |
dc.subject | Akt | - |
dc.subject | PIKE | - |
dc.subject | PI3K | - |
dc.subject | neuron | - |
dc.title | Phosphoinositide 3-kinase enhancer (PIKE) in the brain: Is it simply a phosphoinositide 3-kinase/Akt enhancer? | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1515/revneuro-2011-0066 | - |
dc.identifier.pmid | 22499674 | - |
dc.identifier.scopus | eid_2-s2.0-84861051747 | - |
dc.identifier.volume | 23 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 153 | - |
dc.identifier.epage | 161 | - |
dc.identifier.isi | WOS:000304248400004 | - |
dc.identifier.issnl | 0334-1763 | - |