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- Publisher Website: 10.1096/fj.03-0839fje
- Scopus: eid_2-s2.0-2942749277
- PMID: 14977878
- WOS: WOS:000220425000018
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Article: Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allografts
Title | Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allografts |
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Authors | |
Issue Date | 2004 |
Publisher | Federation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/ |
Citation | The FASEB Journal, 2004, v. 18 n. 6, p. 765-767 How to Cite? |
Abstract | Biliverdin, a product of heme oxygenase-1 (HO-1) enzymatic action, is converted into bilirubin, which has been considered a waste product in the past. We now show that administration of biliverdin has a salutary effect in organ transplantation. A brief course of treatment with biliverdin leads to long-term survival of H-2 incompatible heart allografts. Furthermore, those recipients harboring long-surviving (>100 days) allografts were tolerant to donor antigens indicated by the acceptance of second donor strain hearts but not third-party grafts. Treatment with biliverdin decreased intragraft leukocyte infiltration and inhibited T cell proliferation. Likely related to tolerance induction, biliverdin interferes with T cell signaling by inhibiting activation of nuclear factor of activated T cells (NFAT) and nuclear factor kappaB (NF-kappaB), two transcription factors involved in interleukin-2 (IL-2) transcription and T cell proliferation, as well as suppressing Th1 interferon-gamma (IFN-gamma) production in vitro. These findings support the potential use of biliverdin, a natural product, in transplantation and other T cell mediated immune disorders. |
Persistent Identifier | http://hdl.handle.net/10722/224586 |
ISSN | 2023 Impact Factor: 4.4 2023 SCImago Journal Rankings: 1.412 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Yamashita, K | - |
dc.contributor.author | McDaid, J | - |
dc.contributor.author | Ollinger, RO | - |
dc.contributor.author | Tsui, TY | - |
dc.contributor.author | Berberat, PO | - |
dc.contributor.author | Usheva, A | - |
dc.contributor.author | Csizmadia, E | - |
dc.contributor.author | Smith, RN | - |
dc.contributor.author | Soares, MP | - |
dc.contributor.author | Bach, FH | - |
dc.date.accessioned | 2016-04-08T03:46:35Z | - |
dc.date.available | 2016-04-08T03:46:35Z | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | The FASEB Journal, 2004, v. 18 n. 6, p. 765-767 | - |
dc.identifier.issn | 0892-6638 | - |
dc.identifier.uri | http://hdl.handle.net/10722/224586 | - |
dc.description.abstract | Biliverdin, a product of heme oxygenase-1 (HO-1) enzymatic action, is converted into bilirubin, which has been considered a waste product in the past. We now show that administration of biliverdin has a salutary effect in organ transplantation. A brief course of treatment with biliverdin leads to long-term survival of H-2 incompatible heart allografts. Furthermore, those recipients harboring long-surviving (>100 days) allografts were tolerant to donor antigens indicated by the acceptance of second donor strain hearts but not third-party grafts. Treatment with biliverdin decreased intragraft leukocyte infiltration and inhibited T cell proliferation. Likely related to tolerance induction, biliverdin interferes with T cell signaling by inhibiting activation of nuclear factor of activated T cells (NFAT) and nuclear factor kappaB (NF-kappaB), two transcription factors involved in interleukin-2 (IL-2) transcription and T cell proliferation, as well as suppressing Th1 interferon-gamma (IFN-gamma) production in vitro. These findings support the potential use of biliverdin, a natural product, in transplantation and other T cell mediated immune disorders. | - |
dc.language | eng | - |
dc.publisher | Federation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/ | - |
dc.relation.ispartof | The FASEB Journal | - |
dc.subject.mesh | Biliverdine - metabolism - pharmacology - therapeutic use | - |
dc.subject.mesh | Heart Transplantation - immunology - pathology | - |
dc.subject.mesh | Nuclear Proteins | - |
dc.subject.mesh | T-Lymphocytes - drug effects - immunology | - |
dc.subject.mesh | Transplantation Toleranc | - |
dc.title | Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allografts | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1096/fj.03-0839fje | - |
dc.identifier.pmid | 14977878 | - |
dc.identifier.scopus | eid_2-s2.0-2942749277 | - |
dc.identifier.hkuros | 89297 | - |
dc.identifier.volume | 18 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 765 | - |
dc.identifier.epage | 767 | - |
dc.identifier.isi | WOS:000220425000018 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0892-6638 | - |