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- Publisher Website: 10.1016/S0024-3205(02)02013-1
- Scopus: eid_2-s2.0-0037144316
- PMID: 12204774
- WOS: WOS:000177963500007
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Article: Anticancer Activity of Hemsleya Amabilis Extract
Title | Anticancer Activity of Hemsleya Amabilis Extract |
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Authors | |
Issue Date | 2002 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie |
Citation | Life Sciences, 2002, v. 71 n. 18, p. 2161-2170 How to Cite? |
Abstract | Hemsleya amabilis extract is derived from the medicinal herb Hemsleya amabilis, which has long been used to treat cancer and many other conditions. The underlying mechanism is not clear. To investigate Hemsleya amabili's anticancer activity, we have treated different types of cancer cells including human astrocytoma U87 cells, breast cancer cells MDA-MB-231and Jurkat cells with Hemsleya amabilis extract. This agent significantly inhibited tumor cell growth and colony formation at various concentrations. When astrocytoma cells were seeded in the presence of Hemsleya amabilis extract at very low concentrations, cell spreading was greatly inhibited. Hemsleya amabilis extract also promoted tumor cell death in all the tested cell lines, but with varied sensitivities. Apoptotic assays with Annexin V staining demonstrated that Hemsleya amabilis extract induced astrocytoma cell apoptosis at different concentrations. |
Persistent Identifier | http://hdl.handle.net/10722/224096 |
ISSN | 2023 Impact Factor: 5.2 2023 SCImago Journal Rankings: 1.257 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wu, J | - |
dc.contributor.author | Wu, Y | - |
dc.contributor.author | Yang, BB | - |
dc.date.accessioned | 2016-03-23T07:08:46Z | - |
dc.date.available | 2016-03-23T07:08:46Z | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Life Sciences, 2002, v. 71 n. 18, p. 2161-2170 | - |
dc.identifier.issn | 0024-3205 | - |
dc.identifier.uri | http://hdl.handle.net/10722/224096 | - |
dc.description.abstract | Hemsleya amabilis extract is derived from the medicinal herb Hemsleya amabilis, which has long been used to treat cancer and many other conditions. The underlying mechanism is not clear. To investigate Hemsleya amabili's anticancer activity, we have treated different types of cancer cells including human astrocytoma U87 cells, breast cancer cells MDA-MB-231and Jurkat cells with Hemsleya amabilis extract. This agent significantly inhibited tumor cell growth and colony formation at various concentrations. When astrocytoma cells were seeded in the presence of Hemsleya amabilis extract at very low concentrations, cell spreading was greatly inhibited. Hemsleya amabilis extract also promoted tumor cell death in all the tested cell lines, but with varied sensitivities. Apoptotic assays with Annexin V staining demonstrated that Hemsleya amabilis extract induced astrocytoma cell apoptosis at different concentrations. | - |
dc.language | eng | - |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie | - |
dc.relation.ispartof | Life Sciences | - |
dc.rights | Posting accepted manuscript (postprint): © <year>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject.mesh | Antineoplastic Agents, Phytogenic - pharmacology | - |
dc.subject.mesh | Apoptosis - drug effects | - |
dc.subject.mesh | Cell Survival - drug effects | - |
dc.subject.mesh | Plant Extracts - pharmacology | - |
dc.subject.mesh | Plants, Medicinal - chemistry | - |
dc.title | Anticancer Activity of Hemsleya Amabilis Extract | - |
dc.type | Article | - |
dc.identifier.email | Wu, J: jwuaa@hkucc.hku.hk | - |
dc.identifier.doi | 10.1016/S0024-3205(02)02013-1 | - |
dc.identifier.pmid | 12204774 | - |
dc.identifier.scopus | eid_2-s2.0-0037144316 | - |
dc.identifier.hkuros | 106096 | - |
dc.identifier.volume | 71 | - |
dc.identifier.issue | 18 | - |
dc.identifier.spage | 2161 | - |
dc.identifier.epage | 2170 | - |
dc.identifier.isi | WOS:000177963500007 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0024-3205 | - |