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Article: Biomimetic synthesis of the composites of hydroxyapatite and chitosan-phosphorylated chitosan polyelectrolyte complex

TitleBiomimetic synthesis of the composites of hydroxyapatite and chitosan-phosphorylated chitosan polyelectrolyte complex
Authors
Li, QLChen, ZQDarvell, BWZeng, QLi, GOu, GMWu, MY
KeywordsComplexation
Crystal growth
Drug dosage
Nanostructured materials
Porous materials
Issue Date2006
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/matlet
Citation
Materials Letters, 2006, v. 60 n. 29-30, p. 3533-3536 How to Cite?
DOI: http://dx.doi.org/10.1016/j.matlet.2006.03.046
AbstractA polyelectrolyte complex (PEC) composed of chitosan (CS) and phosphorylated chitosan (PCS) was used to encapsulate a calcium phosphate by a biomimetic method. An acidic CS (polycation) solution containing calcium and phosphate ions (Ca2+: 6 mM, Ca/P = 1.67) was added into a PCS (polyanion) solution leading to the formation of a polyelectrolyte complex (PEC) with nanoscopic carbonate-containing, low-crystallinity hydroxyapatite (HA) distributed evenly in the fibrils of the PEC by controlled crystal growth. The resulting composite material, PEC–HA, has a complicated porous structure that is expected to have high biocompatibility and that may be of use as materials for bone replacement and a carrier for controlled-release therapeutic agents.
Persistent Identifierhttp://hdl.handle.net/10722/222431
ISSN
0167-577X
2023 Impact Factor: 2.7
2023 SCImago Journal Rankings: 0.602
ISI Accession Number ID
WOS:000242469000022

 

DC FieldValueLanguage
dc.contributor.authorLi, QL-
dc.contributor.authorChen, ZQ-
dc.contributor.authorDarvell, BW-
dc.contributor.authorZeng, Q-
dc.contributor.authorLi, G-
dc.contributor.authorOu, GM-
dc.contributor.authorWu, MY-
dc.date.accessioned2016-01-18T04:02:52Z-
dc.date.available2016-01-18T04:02:52Z-
dc.date.issued2006-
dc.identifier.citationMaterials Letters, 2006, v. 60 n. 29-30, p. 3533-3536-
dc.identifier.issn0167-577X-
dc.identifier.urihttp://hdl.handle.net/10722/222431-
dc.description.abstractA polyelectrolyte complex (PEC) composed of chitosan (CS) and phosphorylated chitosan (PCS) was used to encapsulate a calcium phosphate by a biomimetic method. An acidic CS (polycation) solution containing calcium and phosphate ions (Ca2+: 6 mM, Ca/P = 1.67) was added into a PCS (polyanion) solution leading to the formation of a polyelectrolyte complex (PEC) with nanoscopic carbonate-containing, low-crystallinity hydroxyapatite (HA) distributed evenly in the fibrils of the PEC by controlled crystal growth. The resulting composite material, PEC–HA, has a complicated porous structure that is expected to have high biocompatibility and that may be of use as materials for bone replacement and a carrier for controlled-release therapeutic agents.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/matlet-
dc.relation.ispartofMaterials Letters-
dc.rights© <2006>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.subjectComplexation-
dc.subjectCrystal growth-
dc.subjectDrug dosage-
dc.subjectNanostructured materials-
dc.subjectPorous materials-
dc.titleBiomimetic synthesis of the composites of hydroxyapatite and chitosan-phosphorylated chitosan polyelectrolyte complex-
dc.typeArticle-
dc.identifier.emailDarvell, BW: hrdubwd@hkucc.hku.hk-
dc.identifier.authorityDarvell, BW=rp00007-
dc.identifier.doi10.1016/j.matlet.2006.03.046-
dc.identifier.scopuseid_2-s2.0-33750421880-
dc.identifier.hkuros128898-
dc.identifier.volume60-
dc.identifier.issue29-30-
dc.identifier.spage3533-
dc.identifier.epage3536-
dc.identifier.isiWOS:000242469000022-
dc.publisher.placeNetherlands-
dc.identifier.issnl0167-577X-

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