File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.meegid.2013.09.029
- Scopus: eid_2-s2.0-84886850346
- WOS: WOS:000327701200053
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Viral evolution explains the associations among hepatitis C virus genotype, clinical outcomes, and human genetic variation
Title | Viral evolution explains the associations among hepatitis C virus genotype, clinical outcomes, and human genetic variation |
---|---|
Authors | |
Keywords | Co-evolution Hepatitis C virus Phylogeny SNPs IFNL3 |
Issue Date | 2013 |
Publisher | Elsevier BV. |
Citation | Infection Genetics and Evolution, 2013, v. 20, p. 418-421 How to Cite? |
Abstract | Specific human polymorphisms, most commonly found in Central Africa, can predict the success of drug treatment against the hepatitis C virus (HCV), a significant and globally-distributed human pathogen. However, this association is only found for a subset of HCV genotypes. Despite receiving considerable attention in the medical and virological literature, no evolutionary explanation for this curious pattern has been put forward. Here we suggest that the ‘drug treatment resistance’ phenotype exhibited today by some HCV genotypes evolved hundreds to thousands of years ago in response to human genetic variation local to Central Africa: an adaptation that has since accrued a new function in the era of anti-viral drug treatment. This could represent one of the oldest known examples of viral exaptation at the population level. |
Persistent Identifier | http://hdl.handle.net/10722/221827 |
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 0.718 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rose, R | - |
dc.contributor.author | Markov, PV | - |
dc.contributor.author | Lam, TY | - |
dc.contributor.author | Pybus, OG | - |
dc.date.accessioned | 2015-12-10T04:03:54Z | - |
dc.date.available | 2015-12-10T04:03:54Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Infection Genetics and Evolution, 2013, v. 20, p. 418-421 | - |
dc.identifier.issn | 1567-1348 | - |
dc.identifier.uri | http://hdl.handle.net/10722/221827 | - |
dc.description.abstract | Specific human polymorphisms, most commonly found in Central Africa, can predict the success of drug treatment against the hepatitis C virus (HCV), a significant and globally-distributed human pathogen. However, this association is only found for a subset of HCV genotypes. Despite receiving considerable attention in the medical and virological literature, no evolutionary explanation for this curious pattern has been put forward. Here we suggest that the ‘drug treatment resistance’ phenotype exhibited today by some HCV genotypes evolved hundreds to thousands of years ago in response to human genetic variation local to Central Africa: an adaptation that has since accrued a new function in the era of anti-viral drug treatment. This could represent one of the oldest known examples of viral exaptation at the population level. | - |
dc.language | eng | - |
dc.publisher | Elsevier BV. | - |
dc.relation.ispartof | Infection Genetics and Evolution | - |
dc.rights | © <2013>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | Co-evolution | - |
dc.subject | Hepatitis C virus | - |
dc.subject | Phylogeny | - |
dc.subject | SNPs | - |
dc.subject | IFNL3 | - |
dc.title | Viral evolution explains the associations among hepatitis C virus genotype, clinical outcomes, and human genetic variation | - |
dc.type | Article | - |
dc.identifier.email | Lam, TY: ttylam@hku.hk | - |
dc.identifier.authority | Lam, TY=rp01733 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.meegid.2013.09.029 | - |
dc.identifier.scopus | eid_2-s2.0-84886850346 | - |
dc.identifier.volume | 20 | - |
dc.identifier.spage | 418 | - |
dc.identifier.epage | 421 | - |
dc.identifier.isi | WOS:000327701200053 | - |
dc.publisher.place | Netherlands | - |
dc.identifier.issnl | 1567-1348 | - |