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- Publisher Website: 10.1007/978-1-61779-555-8_18
- Scopus: eid_2-s2.0-84863247440
- PMID: 22307707
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Article: Single marker association analysis for unrelated samples
Title | Single marker association analysis for unrelated samples |
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Authors | |
Keywords | Additive Anova Association Binary Trait Case-Control Design Dominant Genetic Model Genotype Relative Risks Max3 Mode of Inheritance Penetrance Quantitative Trait Rassoc Recessive Robustness |
Issue Date | 2012 |
Publisher | Humana Press, Inc. The Journal's web site is located at http://link.springer.com/bookseries/7651 |
Citation | Methods in Molecular Biology, 2012, v. 850, p. 347-358 How to Cite? |
Abstract | Methods for single marker association analysis are presented for binary and quantitative traits. For a binary trait, we focus on the analysis of retrospective case-control data using Pearson's chi-squared test, the trend test, and a robust test. For a continuous trait, typical methods are based on a linear regression model or the analysis of variance. We illustrate how these tests can be applied using a public available R package "Rassoc" and some existing R functions. Guidelines for choosing these test statistics are provided. © 2012 Springer Science+Business Media, LLC. |
Persistent Identifier | http://hdl.handle.net/10722/221675 |
ISSN | 2023 SCImago Journal Rankings: 0.399 |
PubMed Central ID |
DC Field | Value | Language |
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dc.contributor.author | Zheng, G | - |
dc.contributor.author | Xu, J | - |
dc.contributor.author | Yuan, A | - |
dc.contributor.author | Gastwirth, JL | - |
dc.date.accessioned | 2015-12-04T15:29:00Z | - |
dc.date.available | 2015-12-04T15:29:00Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Methods in Molecular Biology, 2012, v. 850, p. 347-358 | - |
dc.identifier.issn | 1064-3745 | - |
dc.identifier.uri | http://hdl.handle.net/10722/221675 | - |
dc.description.abstract | Methods for single marker association analysis are presented for binary and quantitative traits. For a binary trait, we focus on the analysis of retrospective case-control data using Pearson's chi-squared test, the trend test, and a robust test. For a continuous trait, typical methods are based on a linear regression model or the analysis of variance. We illustrate how these tests can be applied using a public available R package "Rassoc" and some existing R functions. Guidelines for choosing these test statistics are provided. © 2012 Springer Science+Business Media, LLC. | - |
dc.language | eng | - |
dc.publisher | Humana Press, Inc. The Journal's web site is located at http://link.springer.com/bookseries/7651 | - |
dc.relation.ispartof | Methods in Molecular Biology | - |
dc.subject | Additive | - |
dc.subject | Anova | - |
dc.subject | Association | - |
dc.subject | Binary Trait | - |
dc.subject | Case-Control Design | - |
dc.subject | Dominant | - |
dc.subject | Genetic Model | - |
dc.subject | Genotype Relative Risks | - |
dc.subject | Max3 | - |
dc.subject | Mode of Inheritance | - |
dc.subject | Penetrance | - |
dc.subject | Quantitative Trait | - |
dc.subject | Rassoc | - |
dc.subject | Recessive | - |
dc.subject | Robustness | - |
dc.title | Single marker association analysis for unrelated samples | - |
dc.type | Article | - |
dc.identifier.email | Xu, J: xujf@hku.hk | - |
dc.identifier.authority | Xu, J=rp02086 | - |
dc.identifier.doi | 10.1007/978-1-61779-555-8_18 | - |
dc.identifier.pmid | 22307707 | - |
dc.identifier.pmcid | PMC3652252 | - |
dc.identifier.scopus | eid_2-s2.0-84863247440 | - |
dc.identifier.volume | 850 | - |
dc.identifier.spage | 347 | - |
dc.identifier.epage | 358 | - |
dc.identifier.issnl | 1064-3745 | - |