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Article: Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions
Title | Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions |
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Authors | |
Keywords | Conduction Conduction velocity Gap junction Sodium channel Ventricular arrhythmia |
Issue Date | 2015 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.ijcha-journal.com |
Citation | IJC Heart & Vasculature, 2015, v. 9, p. 75-82 How to Cite? |
Abstract | Ventricular arrhythmias arise from disruptions in the normal orderly sequence of electrical activation and recovery of the heart. They can be categorized into disorders affecting predominantly cellular depolarization or repolarization, or those involving action potential (AP) conduction. This article briefly discusses the factors causing conduction abnormalities in the form of unidirectional conduction block and reduced conduction velocity (CV). It then examines the roles that sodium channels and gap junctions play in AP conduction. Finally, it synthesizes experimental results to illustrate molecular mechanisms of how abnormalities in these proteins contribute to such conduction abnormalities and hence ventricular arrhythmogenesis, in acquired pathologies such as acute ischaemia and heart failure, as well as inherited arrhythmic syndromes. © 2015 The Authors. |
Description | Open Access Journal |
Persistent Identifier | http://hdl.handle.net/10722/221537 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.753 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Tse, G | - |
dc.contributor.author | Yeo, JM | - |
dc.date.accessioned | 2015-11-30T03:32:57Z | - |
dc.date.available | 2015-11-30T03:32:57Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | IJC Heart & Vasculature, 2015, v. 9, p. 75-82 | - |
dc.identifier.issn | 2352-9067 | - |
dc.identifier.uri | http://hdl.handle.net/10722/221537 | - |
dc.description | Open Access Journal | - |
dc.description.abstract | Ventricular arrhythmias arise from disruptions in the normal orderly sequence of electrical activation and recovery of the heart. They can be categorized into disorders affecting predominantly cellular depolarization or repolarization, or those involving action potential (AP) conduction. This article briefly discusses the factors causing conduction abnormalities in the form of unidirectional conduction block and reduced conduction velocity (CV). It then examines the roles that sodium channels and gap junctions play in AP conduction. Finally, it synthesizes experimental results to illustrate molecular mechanisms of how abnormalities in these proteins contribute to such conduction abnormalities and hence ventricular arrhythmogenesis, in acquired pathologies such as acute ischaemia and heart failure, as well as inherited arrhythmic syndromes. © 2015 The Authors. | - |
dc.language | eng | - |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.ijcha-journal.com | - |
dc.relation.ispartof | IJC Heart & Vasculature | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Conduction | - |
dc.subject | Conduction velocity | - |
dc.subject | Gap junction | - |
dc.subject | Sodium channel | - |
dc.subject | Ventricular arrhythmia | - |
dc.title | Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions | - |
dc.type | Article | - |
dc.identifier.email | Tse, G: tseg@hku.hk | - |
dc.identifier.authority | Tse, G=rp02073 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1016/j.ijcha.2015.10.003 | - |
dc.identifier.scopus | eid_2-s2.0-84946014380 | - |
dc.identifier.hkuros | 256279 | - |
dc.identifier.volume | 9 | - |
dc.identifier.spage | 75 | - |
dc.identifier.epage | 82 | - |
dc.identifier.isi | WOS:000218810500017 | - |
dc.publisher.place | Netherlands | - |
dc.identifier.issnl | 2352-9067 | - |