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- Publisher Website: 10.1016/j.trre.2010.01.002
- Scopus: eid_2-s2.0-77950865221
- PMID: 20153159
- WOS: WOS:000208545300002
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Article: Regulatory T Cells In Transplantation: Does Extracellular Adenosine Triphosphate Metabolism Through Cd39 Play A Crucial Role?
Title | Regulatory T Cells In Transplantation: Does Extracellular Adenosine Triphosphate Metabolism Through Cd39 Play A Crucial Role? |
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Authors | |
Issue Date | 2010 |
Publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/trre |
Citation | Transplantation Reviews, 2010, v. 24 n. 2, p. 52-66 How to Cite? |
Abstract | Despite Tremendous Improvements In Short-Term Renal Allograft Survival, Many Patients Still Have Chronic Rejection Or Side Effects Of Nonspecific Immunosuppression. The Discovery Of Foxp3+ Regulatory T Cells (Tregs) Has Revolutionized The Concepts In Immunoregulation And Offers Perspectives For Overcoming Rejection. Recently, A Subset Of Foxp3+Cd39+ Effector/Memory-Like Tregs (Trem) Was Identified. The Role Of Cd39+ Tregs In Immunoregulation Is Supported By The Occurrence Of Alopecia Areata And Experimental Autoimmune Encephalomyelitis In Cd39-Deficient Mice And By The Failure Of Cd39- Tregs To Suppress Contact Hypersensitivity. In Humans, Cd39 Polymorphisms Have Been Associated With Diabetes And Nephropathy, And Multiple Sclerosis Patients Have Reduced Numbers Of Blood Cd39+ Tregs. Preliminary Experiments In A Murine Transplantation Model Showed That Cd39+ Tregs Can Determine Allograft Outcome. Cd39 Degrades The Extracellular Adenosine Triphosphate (Atp) Released During Tissue Injury, Which Otherwise Would Trigger Inflammation. Currently, Our Groups Are Assessing The Role Of Cd39+ Tregs And Extracellular Atp Metabolism In Clinical Transplantation And Whether Tolerogenic Treg Profiles Possess Immunopredictive Value, Envisioning The Development Of Clinical Trials Using Cd39+ Treg-Based Vaccination For Autoimmunity Or Transplantation. This Is A Comprehensive Review On The Fundamentals Of Treg Biology, The Potential Role Of Atp Metabolism In Immunoregulation, And The Potential Use Of Treg-Based Immunotherapy In Transplantation. © 2010 Elsevier Inc. |
Persistent Identifier | http://hdl.handle.net/10722/220766 |
ISSN | 2023 Impact Factor: 3.6 2023 SCImago Journal Rankings: 1.062 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Salcido-Ochoa, F | en_US |
dc.contributor.author | Tsang, J | en_US |
dc.contributor.author | Tam, PKH | en_US |
dc.contributor.author | Falk, K | en_US |
dc.contributor.author | Rotzschke, O | en_US |
dc.date.accessioned | 2015-10-16T08:10:09Z | - |
dc.date.available | 2015-10-16T08:10:09Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Transplantation Reviews, 2010, v. 24 n. 2, p. 52-66 | en_US |
dc.identifier.issn | 0955-470X | - |
dc.identifier.uri | http://hdl.handle.net/10722/220766 | - |
dc.description.abstract | Despite Tremendous Improvements In Short-Term Renal Allograft Survival, Many Patients Still Have Chronic Rejection Or Side Effects Of Nonspecific Immunosuppression. The Discovery Of Foxp3+ Regulatory T Cells (Tregs) Has Revolutionized The Concepts In Immunoregulation And Offers Perspectives For Overcoming Rejection. Recently, A Subset Of Foxp3+Cd39+ Effector/Memory-Like Tregs (Trem) Was Identified. The Role Of Cd39+ Tregs In Immunoregulation Is Supported By The Occurrence Of Alopecia Areata And Experimental Autoimmune Encephalomyelitis In Cd39-Deficient Mice And By The Failure Of Cd39- Tregs To Suppress Contact Hypersensitivity. In Humans, Cd39 Polymorphisms Have Been Associated With Diabetes And Nephropathy, And Multiple Sclerosis Patients Have Reduced Numbers Of Blood Cd39+ Tregs. Preliminary Experiments In A Murine Transplantation Model Showed That Cd39+ Tregs Can Determine Allograft Outcome. Cd39 Degrades The Extracellular Adenosine Triphosphate (Atp) Released During Tissue Injury, Which Otherwise Would Trigger Inflammation. Currently, Our Groups Are Assessing The Role Of Cd39+ Tregs And Extracellular Atp Metabolism In Clinical Transplantation And Whether Tolerogenic Treg Profiles Possess Immunopredictive Value, Envisioning The Development Of Clinical Trials Using Cd39+ Treg-Based Vaccination For Autoimmunity Or Transplantation. This Is A Comprehensive Review On The Fundamentals Of Treg Biology, The Potential Role Of Atp Metabolism In Immunoregulation, And The Potential Use Of Treg-Based Immunotherapy In Transplantation. © 2010 Elsevier Inc. | en_US |
dc.language | eng | en_US |
dc.publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/trre | en_US |
dc.relation.ispartof | Transplantation Reviews | en_US |
dc.title | Regulatory T Cells In Transplantation: Does Extracellular Adenosine Triphosphate Metabolism Through Cd39 Play A Crucial Role? | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tam, PKH:paultam@hkucc.hku.hk | - |
dc.identifier.authority | Tam, PKH=rp00060 | - |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.trre.2010.01.002 | - |
dc.identifier.pmid | 20153159 | - |
dc.identifier.scopus | eid_2-s2.0-77950865221 | - |
dc.identifier.hkuros | 320817 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-77950865221&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 24 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 52 | - |
dc.identifier.epage | 66 | - |
dc.identifier.isi | WOS:000208545300002 | - |
dc.identifier.issnl | 0955-470X | - |