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- Publisher Website: 10.1523/jneurosci.0230-14.2014
- Scopus: eid_2-s2.0-84907494890
- WOS: WOS:000343141100010
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Article: EOL-1, the homolog of the mammalian Dom3Z, regulates olfactory learning in C. elegans
Title | EOL-1, the homolog of the mammalian Dom3Z, regulates olfactory learning in C. elegans |
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Authors | |
Keywords | Invertebrate olfactory plasticity Molecular underpinnings of learning pre-mRNA quality control |
Issue Date | 2014 |
Citation | The Journal of Neuroscience, 2014, v. 34 n. 40, p. 13364-13370 How to Cite? |
Abstract | Learning is an essential function of the nervous system. However, our understanding of molecular underpinnings of learning remains incomplete. Here, we characterize a conserved protein EOL-1 that regulates olfactory learning in Caenorhabditis elegans. A recessive allele of eol-1 (enhanced olfactory learning) learns better to adjust its olfactory preference for bacteria foods and eol-1 acts in the URX sensory neurons to regulate learning. The mammalian homolog of EOL-1, Dom3Z, which regulates quality control of pre-mRNAs, can substitute the function of EOL-1 in learning regulation, demonstrating functional conservation between these homologs. Mutating the residues of Dom3Z that are critical for its enzymatic activity, and the equivalent residues in EOL-1, abolishes the function of these proteins in learning. Together, our results provide insights into the function of EOL-1/Dom3Z and suggest that its activity in pre-mRNA quality control is involved in neural plasticity. |
Persistent Identifier | http://hdl.handle.net/10722/220479 |
ISSN | 2023 Impact Factor: 4.4 2023 SCImago Journal Rankings: 2.321 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Shen, Y | - |
dc.contributor.author | Zhang, J | - |
dc.contributor.author | Calarco, JA | - |
dc.contributor.author | Zhang, Y | - |
dc.date.accessioned | 2015-10-16T06:43:29Z | - |
dc.date.available | 2015-10-16T06:43:29Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | The Journal of Neuroscience, 2014, v. 34 n. 40, p. 13364-13370 | - |
dc.identifier.issn | 0270-6474 | - |
dc.identifier.uri | http://hdl.handle.net/10722/220479 | - |
dc.description.abstract | Learning is an essential function of the nervous system. However, our understanding of molecular underpinnings of learning remains incomplete. Here, we characterize a conserved protein EOL-1 that regulates olfactory learning in Caenorhabditis elegans. A recessive allele of eol-1 (enhanced olfactory learning) learns better to adjust its olfactory preference for bacteria foods and eol-1 acts in the URX sensory neurons to regulate learning. The mammalian homolog of EOL-1, Dom3Z, which regulates quality control of pre-mRNAs, can substitute the function of EOL-1 in learning regulation, demonstrating functional conservation between these homologs. Mutating the residues of Dom3Z that are critical for its enzymatic activity, and the equivalent residues in EOL-1, abolishes the function of these proteins in learning. Together, our results provide insights into the function of EOL-1/Dom3Z and suggest that its activity in pre-mRNA quality control is involved in neural plasticity. | - |
dc.language | eng | - |
dc.relation.ispartof | The Journal of Neuroscience | - |
dc.subject | Invertebrate olfactory plasticity | - |
dc.subject | Molecular underpinnings of learning | - |
dc.subject | pre-mRNA quality control | - |
dc.title | EOL-1, the homolog of the mammalian Dom3Z, regulates olfactory learning in C. elegans | - |
dc.type | Article | - |
dc.identifier.email | Zhang, J: jzhang1@hku.hk | - |
dc.identifier.authority | Zhang, J=rp01713 | - |
dc.identifier.doi | 10.1523/jneurosci.0230-14.2014 | - |
dc.identifier.pmcid | PMC4180473 | - |
dc.identifier.scopus | eid_2-s2.0-84907494890 | - |
dc.identifier.hkuros | 255691 | - |
dc.identifier.volume | 34 | - |
dc.identifier.issue | 40 | - |
dc.identifier.spage | 13364 | - |
dc.identifier.epage | 13370 | - |
dc.identifier.isi | WOS:000343141100010 | - |
dc.identifier.f1000 | 719128660 | - |
dc.identifier.issnl | 0270-6474 | - |