Deep brain stimulation in dementia-related disorders

Abstract

Memory loss is the key symptom of dementia-related disorders, including the prevalent Alzheimer's disease (AD). To date, pharmacological treatments for AD have limited and short-lasting effects. Therefore, researchers are investigating novel therapies such as deep brain stimulation (DBS) to treat memory impairment and to reduce or stop the progression of it. Clinical and preclinical studies have been performed and stimulations of the fornix, entorhinal cortex and nucleus basalis of Meynert have been carried out. The results of these studies suggest that DBS has the potential to enhance memory functions in patients and animal models. The mechanisms underlying memory enhancement may include the release of specific neurotransmitters and neuroplasticity. Some authors suggest that DBS might even be disease-modifying. Nevertheless, it is still premature to conclude that DBS can be used in the treatment of AD, and the field will wait for the results of ongoing clinical trials. © 2013 Elsevier Ltd.