File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1007/s12311-010-0228-z
- Scopus: eid_2-s2.0-79952697936
- PMID: 21076996
- WOS: WOS:000287330600008
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Periaqueductal grey stimulation induced panic-like behaviour is accompanied by deactivation of the deep cerebellar nuclei
Title | Periaqueductal grey stimulation induced panic-like behaviour is accompanied by deactivation of the deep cerebellar nuclei |
---|---|
Authors | |
Keywords | Deep brain stimulation Cerebellum Escape behaviour Periaqueductal grey Ventromedial hypothalamus |
Issue Date | 2011 |
Citation | Cerebellum, 2011, v. 10, n. 1, p. 61-69 How to Cite? |
Abstract | Until recently, the cerebellum was primarily considered to be a structure involved in motor behaviour. New anatomical and clinical evidence has shown that the cerebellum is also involved in higher cognitive functions and non-motor behavioural changes. Functional imaging in patients with anxiety disorders and in cholecystokinin tetrapeptide-induced panic-attacks shows activation changes in the cerebellum. Deep brain stimulation of the dorsolateral periaqueductal grey (dlPAG) and the ventromedial hypothalamus (VMH) in rats has been shown to induce escape behaviour, which mimics a panic attack in humans. We used this animal model to study the neuronal activation in the deep cerebellar nuclei (DCbN) using c-Fos immunohistochemistry. c-Fos expression in the DCbN decreased significantly after inducing escape behaviour by stimulation of the dlPAG and the VMH, indicating that the DCbN were deactivated. This study demonstrates that the DCbN are directly or indirectly involved in panic attacks. We suggest that the cerebellum plays a role in the selection of relevant information, and that deactivation of the cerebellar nuclei is required to allow inappropriate behaviour to occur, such as panic attacks. © 2010 The Author(s). |
Persistent Identifier | http://hdl.handle.net/10722/219869 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 1.258 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moers-Hornikx, Véronique M P | - |
dc.contributor.author | Vles, Johan S H | - |
dc.contributor.author | Lim, Lee Wei | - |
dc.contributor.author | Ayyildiz, Mustafa | - |
dc.contributor.author | Kaplan, Suleyman | - |
dc.contributor.author | Gavilanes, Antonio W D | - |
dc.contributor.author | Hoogland, Govert | - |
dc.contributor.author | Steinbusch, Harry W M | - |
dc.contributor.author | Temel, Yasin | - |
dc.date.accessioned | 2015-09-24T04:44:11Z | - |
dc.date.available | 2015-09-24T04:44:11Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Cerebellum, 2011, v. 10, n. 1, p. 61-69 | - |
dc.identifier.issn | 1473-4222 | - |
dc.identifier.uri | http://hdl.handle.net/10722/219869 | - |
dc.description.abstract | Until recently, the cerebellum was primarily considered to be a structure involved in motor behaviour. New anatomical and clinical evidence has shown that the cerebellum is also involved in higher cognitive functions and non-motor behavioural changes. Functional imaging in patients with anxiety disorders and in cholecystokinin tetrapeptide-induced panic-attacks shows activation changes in the cerebellum. Deep brain stimulation of the dorsolateral periaqueductal grey (dlPAG) and the ventromedial hypothalamus (VMH) in rats has been shown to induce escape behaviour, which mimics a panic attack in humans. We used this animal model to study the neuronal activation in the deep cerebellar nuclei (DCbN) using c-Fos immunohistochemistry. c-Fos expression in the DCbN decreased significantly after inducing escape behaviour by stimulation of the dlPAG and the VMH, indicating that the DCbN were deactivated. This study demonstrates that the DCbN are directly or indirectly involved in panic attacks. We suggest that the cerebellum plays a role in the selection of relevant information, and that deactivation of the cerebellar nuclei is required to allow inappropriate behaviour to occur, such as panic attacks. © 2010 The Author(s). | - |
dc.language | eng | - |
dc.relation.ispartof | Cerebellum | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Deep brain stimulation | - |
dc.subject | Cerebellum | - |
dc.subject | Escape behaviour | - |
dc.subject | Periaqueductal grey | - |
dc.subject | Ventromedial hypothalamus | - |
dc.title | Periaqueductal grey stimulation induced panic-like behaviour is accompanied by deactivation of the deep cerebellar nuclei | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1007/s12311-010-0228-z | - |
dc.identifier.pmid | 21076996 | - |
dc.identifier.scopus | eid_2-s2.0-79952697936 | - |
dc.identifier.volume | 10 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 61 | - |
dc.identifier.epage | 69 | - |
dc.identifier.eissn | 1473-4230 | - |
dc.identifier.isi | WOS:000287330600008 | - |
dc.identifier.issnl | 1473-4222 | - |