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- Publisher Website: 10.1016/j.jchemneu.2009.06.011
- Scopus: eid_2-s2.0-68349155698
- PMID: 19589381
- WOS: WOS:000269734900001
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Article: Fos immunoreactivity in the rat forebrain induced by electrical stimulation of the dorsolateral periaqueductal gray matter
Title | Fos immunoreactivity in the rat forebrain induced by electrical stimulation of the dorsolateral periaqueductal gray matter |
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Authors | |
Keywords | Forebrain Escape behaviour c-Fos immunoreactivity Periaqueductal gray Panic-like behaviour Neuroanatomy Fear-like behaviour |
Issue Date | 2009 |
Citation | Journal of Chemical Neuroanatomy, 2009, v. 38, n. 2, p. 83-96 How to Cite? |
Abstract | Electrical stimulation of the dorsolateral periaqueductal gray (dlPAG) matter induces panic- or fear-like responses with intense emotional distress and severe anxiety. In this study, we evoked panic-like behaviour by dlPAG stimulation and evaluated the effect on neuronal activation in different brain regions. The number of c-Fos immunoreactive (c-Fos-ir) cells was measured semi-quantitatively through series of stained rat brain sections. Our results demonstrate strong neural activation in the medial prefrontal cortex, orbital cortex, anterior olfactory nuclei, secondary motor cortex, and the somatosensory cortex. Moderate increases in the number of c-Fos-ir cells were detected in various regions, including the hypothalamus, amygdala, and striatum. Additionally, there was mild expression of c-Fos-ir cells in the hippocampus, thalamus, and habenula regions. In conclusion, we have shown that deep brain stimulation of the dlPAG produced a distinctive pattern of neuronal activation across forebrain regions as compared to the sham and control animals. © 2009 Elsevier B.V. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/219858 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.669 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lim, Lee Wei | - |
dc.contributor.author | Temel, Yasin | - |
dc.contributor.author | Visser-Vandewalle, Veerle | - |
dc.contributor.author | Blokland, Arjan | - |
dc.contributor.author | Steinbusch, Harry | - |
dc.date.accessioned | 2015-09-24T04:44:08Z | - |
dc.date.available | 2015-09-24T04:44:08Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Journal of Chemical Neuroanatomy, 2009, v. 38, n. 2, p. 83-96 | - |
dc.identifier.issn | 0891-0618 | - |
dc.identifier.uri | http://hdl.handle.net/10722/219858 | - |
dc.description.abstract | Electrical stimulation of the dorsolateral periaqueductal gray (dlPAG) matter induces panic- or fear-like responses with intense emotional distress and severe anxiety. In this study, we evoked panic-like behaviour by dlPAG stimulation and evaluated the effect on neuronal activation in different brain regions. The number of c-Fos immunoreactive (c-Fos-ir) cells was measured semi-quantitatively through series of stained rat brain sections. Our results demonstrate strong neural activation in the medial prefrontal cortex, orbital cortex, anterior olfactory nuclei, secondary motor cortex, and the somatosensory cortex. Moderate increases in the number of c-Fos-ir cells were detected in various regions, including the hypothalamus, amygdala, and striatum. Additionally, there was mild expression of c-Fos-ir cells in the hippocampus, thalamus, and habenula regions. In conclusion, we have shown that deep brain stimulation of the dlPAG produced a distinctive pattern of neuronal activation across forebrain regions as compared to the sham and control animals. © 2009 Elsevier B.V. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Chemical Neuroanatomy | - |
dc.subject | Forebrain | - |
dc.subject | Escape behaviour | - |
dc.subject | c-Fos immunoreactivity | - |
dc.subject | Periaqueductal gray | - |
dc.subject | Panic-like behaviour | - |
dc.subject | Neuroanatomy | - |
dc.subject | Fear-like behaviour | - |
dc.title | Fos immunoreactivity in the rat forebrain induced by electrical stimulation of the dorsolateral periaqueductal gray matter | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.jchemneu.2009.06.011 | - |
dc.identifier.pmid | 19589381 | - |
dc.identifier.scopus | eid_2-s2.0-68349155698 | - |
dc.identifier.volume | 38 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 83 | - |
dc.identifier.epage | 96 | - |
dc.identifier.isi | WOS:000269734900001 | - |
dc.identifier.issnl | 0891-0618 | - |