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- Publisher Website: 10.2741/3349
- Scopus: eid_2-s2.0-63849126045
- PMID: 19273171
- WOS: WOS:000262352400122
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Article: Cognitive and limbic effects of deep brain stimulation in preclinical studies
Title | Cognitive and limbic effects of deep brain stimulation in preclinical studies |
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Authors | |
Keywords | Serotonin Huntington's disease Forced swim task Neurological Nucleus accumbens Obsessive-compulsive disorder Panic Parkinson's disease Psychiatric Review Subthalamic nucleus Animal models Depression Deep brain stimulation Basal ganglia |
Issue Date | 2009 |
Citation | Frontiers in Bioscience, 2009, v. 14, n. 5, p. 1891-1901 How to Cite? |
Abstract | The use of deep brain stimulation (DBS) to control severely disabling neurological and psychiatric conditions is an exciting and fast emerging area of neuroscience. Deep brain stimulation has generally the same clinical effects as a lesion with respect to the improvement of clinical disability, but has more advantages such as its adjustability and reversibility. To this day, fundamental knowledge regarding the application of electrical currents to deep brain structures is far from complete. Despite improving key symptoms in movement disorders, DBS can be associated with the occurrence of a variety of changes in cognitive and limbic functions both in humans and animals. Furthermore, in psychiatric disorders, DBS is primarily used to evoke cognitive and limbic changes to reduce the psychiatric disability. Preclinical DBS experiments have been carried out to investigate the mechanisms underlying the clinical effects of DBS for at least three (interrelated) reasons: to increase our scientific knowledge, to optimize/refine the technology, or to prevent/reduce side-effects. In this review, we will discuss the limbic and cognitive effects of DBS in preclinical studies. |
Persistent Identifier | http://hdl.handle.net/10722/219855 |
ISSN | 2020 Impact Factor: 4.009 2020 SCImago Journal Rankings: 1.117 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Temel, Yasin | - |
dc.contributor.author | Tan, Sonny | - |
dc.contributor.author | Vlamings, Rinske | - |
dc.contributor.author | Sesia, Thibaut | - |
dc.contributor.author | Lim, Lee Wei | - |
dc.contributor.author | Lardeux, Sylvie | - |
dc.contributor.author | Visser-Vandewalle, Veerle | - |
dc.contributor.author | Baunez, Christelle | - |
dc.date.accessioned | 2015-09-24T04:44:06Z | - |
dc.date.available | 2015-09-24T04:44:06Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Frontiers in Bioscience, 2009, v. 14, n. 5, p. 1891-1901 | - |
dc.identifier.issn | 1093-9946 | - |
dc.identifier.uri | http://hdl.handle.net/10722/219855 | - |
dc.description.abstract | The use of deep brain stimulation (DBS) to control severely disabling neurological and psychiatric conditions is an exciting and fast emerging area of neuroscience. Deep brain stimulation has generally the same clinical effects as a lesion with respect to the improvement of clinical disability, but has more advantages such as its adjustability and reversibility. To this day, fundamental knowledge regarding the application of electrical currents to deep brain structures is far from complete. Despite improving key symptoms in movement disorders, DBS can be associated with the occurrence of a variety of changes in cognitive and limbic functions both in humans and animals. Furthermore, in psychiatric disorders, DBS is primarily used to evoke cognitive and limbic changes to reduce the psychiatric disability. Preclinical DBS experiments have been carried out to investigate the mechanisms underlying the clinical effects of DBS for at least three (interrelated) reasons: to increase our scientific knowledge, to optimize/refine the technology, or to prevent/reduce side-effects. In this review, we will discuss the limbic and cognitive effects of DBS in preclinical studies. | - |
dc.language | eng | - |
dc.relation.ispartof | Frontiers in Bioscience | - |
dc.subject | Serotonin | - |
dc.subject | Huntington's disease | - |
dc.subject | Forced swim task | - |
dc.subject | Neurological | - |
dc.subject | Nucleus accumbens | - |
dc.subject | Obsessive-compulsive disorder | - |
dc.subject | Panic | - |
dc.subject | Parkinson's disease | - |
dc.subject | Psychiatric | - |
dc.subject | Review | - |
dc.subject | Subthalamic nucleus | - |
dc.subject | Animal models | - |
dc.subject | Depression | - |
dc.subject | Deep brain stimulation | - |
dc.subject | Basal ganglia | - |
dc.title | Cognitive and limbic effects of deep brain stimulation in preclinical studies | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.2741/3349 | - |
dc.identifier.pmid | 19273171 | - |
dc.identifier.scopus | eid_2-s2.0-63849126045 | - |
dc.identifier.volume | 14 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 1891 | - |
dc.identifier.epage | 1901 | - |
dc.identifier.isi | WOS:000262352400122 | - |
dc.identifier.issnl | 1093-4715 | - |