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- Publisher Website: 10.1016/j.neubiorev.2015.08.004
- Scopus: eid_2-s2.0-84940370134
- PMID: 26363667
- WOS: WOS:000364271200008
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Article: Dorsal raphe nucleus projecting retinal ganglion cells: Why Y cells?
Title | Dorsal raphe nucleus projecting retinal ganglion cells: Why Y cells? |
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Authors | |
Keywords | Alpha cells Dorsal raphe nucleus Retinal ganglion cells Y cells |
Issue Date | 2015 |
Publisher | Pergamon. The Journal's web site is located at http://www.elsevier.com/locate/neubiorev |
Citation | Neuroscience & Biobehavioral Reviews, 2015, v. 57, p. 118-131 How to Cite? |
Abstract | Retinal ganglion Y (alpha) cells are found in retinas ranging from frogs to mice to primates. The highly conserved nature of the large, fast conducting retinal Y cell is a testament to its fundamental task, although precisely that this task is remained ill-defined. The recent discovery that Y-alpha retinal ganglion cells send axon collaterals to the serotonergic dorsal raphe nucleus (DRN) in addition to the lateral geniculate nucleus (LGN), medial interlaminar nucleus (MIN), pretectum and the superior colliculus (SC) has offered new insights into the important survival tasks performed by these cells with highly branched axons. We propose that in addition to its role in visual perception, the Y-alpha retinal ganglion cell provides concurrent signals via axon collaterals to the DRN, the major source of serotonergic afferents to the forebrain, to dramatically inhibit 5-HT activity during orientation or alerting/ escape responses, which disfacilitates ongoing tonic motor activity while dis-inhibiting sensory information processing throughout the visual system. The new data provide a fresh view of these evolutionarily old retinal ganglion cells. |
Persistent Identifier | http://hdl.handle.net/10722/218633 |
ISSN | 2023 Impact Factor: 7.5 2023 SCImago Journal Rankings: 2.810 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Pickard, GE | - |
dc.contributor.author | So, KF | - |
dc.contributor.author | Pu, ML | - |
dc.date.accessioned | 2015-09-18T06:48:46Z | - |
dc.date.available | 2015-09-18T06:48:46Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Neuroscience & Biobehavioral Reviews, 2015, v. 57, p. 118-131 | - |
dc.identifier.issn | 0149-7634 | - |
dc.identifier.uri | http://hdl.handle.net/10722/218633 | - |
dc.description.abstract | Retinal ganglion Y (alpha) cells are found in retinas ranging from frogs to mice to primates. The highly conserved nature of the large, fast conducting retinal Y cell is a testament to its fundamental task, although precisely that this task is remained ill-defined. The recent discovery that Y-alpha retinal ganglion cells send axon collaterals to the serotonergic dorsal raphe nucleus (DRN) in addition to the lateral geniculate nucleus (LGN), medial interlaminar nucleus (MIN), pretectum and the superior colliculus (SC) has offered new insights into the important survival tasks performed by these cells with highly branched axons. We propose that in addition to its role in visual perception, the Y-alpha retinal ganglion cell provides concurrent signals via axon collaterals to the DRN, the major source of serotonergic afferents to the forebrain, to dramatically inhibit 5-HT activity during orientation or alerting/ escape responses, which disfacilitates ongoing tonic motor activity while dis-inhibiting sensory information processing throughout the visual system. The new data provide a fresh view of these evolutionarily old retinal ganglion cells. | - |
dc.language | eng | - |
dc.publisher | Pergamon. The Journal's web site is located at http://www.elsevier.com/locate/neubiorev | - |
dc.relation.ispartof | Neuroscience & Biobehavioral Reviews | - |
dc.subject | Alpha cells | - |
dc.subject | Dorsal raphe nucleus | - |
dc.subject | Retinal ganglion cells | - |
dc.subject | Y cells | - |
dc.title | Dorsal raphe nucleus projecting retinal ganglion cells: Why Y cells? | - |
dc.type | Article | - |
dc.identifier.email | So, KF: hrmaskf@hku.hk | - |
dc.identifier.authority | So, KF=rp00329 | - |
dc.identifier.doi | 10.1016/j.neubiorev.2015.08.004 | - |
dc.identifier.pmid | 26363667 | - |
dc.identifier.scopus | eid_2-s2.0-84940370134 | - |
dc.identifier.hkuros | 252213 | - |
dc.identifier.volume | 57 | - |
dc.identifier.spage | 118 | - |
dc.identifier.epage | 131 | - |
dc.identifier.isi | WOS:000364271200008 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0149-7634 | - |