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Article: SIRTain regulators of premature senescence and accelerated aging.
Title | SIRTain regulators of premature senescence and accelerated aging. |
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Authors | |
Keywords | longevity premature aging senescence sirtuins |
Issue Date | 2015 |
Publisher | SPRINGER/Higher Education Press. |
Citation | Protein & Cell, 2015, v. 6, p. 322-333 How to Cite? |
Abstract | The sirtuin proteins constitute class III histone deacetylases (HDACs). These evolutionarily conserved NAD(+)-dependent enzymes form an important component in a variety of cellular and biological processes with highly divergent as well as convergent roles in maintaining metabolic homeostasis, safeguarding genomic integrity, regulating cancer metabolism and also inflammatory responses. Amongst the seven known mammalian sirtuin proteins, SIRT1 has gained much attention due to its widely acknowledged roles in promoting longevity and ameliorating age-associated pathologies. The contributions of other sirtuins in the field of aging are also gradually emerging. Here, we summarize some of the recent discoveries in sirtuins biology which clearly implicate the functions of sirtuin proteins in the regulation of premature cellular senescence and accelerated aging. The roles of sirtuins in various cellular processes have been extrapolated to draw inter-linkage with anti-aging mechanisms. Also, the latest findings on sirtuins which might have potential effects in the process of aging have been reviewed. |
Persistent Identifier | http://hdl.handle.net/10722/216597 |
ISSN | 2023 Impact Factor: 13.6 2023 SCImago Journal Rankings: 4.412 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ghosh, S | - |
dc.contributor.author | Zhou, Z | - |
dc.date.accessioned | 2015-09-18T05:33:21Z | - |
dc.date.available | 2015-09-18T05:33:21Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Protein & Cell, 2015, v. 6, p. 322-333 | - |
dc.identifier.issn | 1674-800X | - |
dc.identifier.uri | http://hdl.handle.net/10722/216597 | - |
dc.description.abstract | The sirtuin proteins constitute class III histone deacetylases (HDACs). These evolutionarily conserved NAD(+)-dependent enzymes form an important component in a variety of cellular and biological processes with highly divergent as well as convergent roles in maintaining metabolic homeostasis, safeguarding genomic integrity, regulating cancer metabolism and also inflammatory responses. Amongst the seven known mammalian sirtuin proteins, SIRT1 has gained much attention due to its widely acknowledged roles in promoting longevity and ameliorating age-associated pathologies. The contributions of other sirtuins in the field of aging are also gradually emerging. Here, we summarize some of the recent discoveries in sirtuins biology which clearly implicate the functions of sirtuin proteins in the regulation of premature cellular senescence and accelerated aging. The roles of sirtuins in various cellular processes have been extrapolated to draw inter-linkage with anti-aging mechanisms. Also, the latest findings on sirtuins which might have potential effects in the process of aging have been reviewed. | - |
dc.language | eng | - |
dc.publisher | SPRINGER/Higher Education Press. | - |
dc.relation.ispartof | Protein & Cell | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | longevity | - |
dc.subject | premature aging | - |
dc.subject | senescence | - |
dc.subject | sirtuins | - |
dc.title | SIRTain regulators of premature senescence and accelerated aging. | - |
dc.type | Article | - |
dc.identifier.email | Zhou, Z: zhongjun@hku.hk | - |
dc.identifier.authority | Zhou, Z=rp00503 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1007/s13238-015-0149-1 | - |
dc.identifier.scopus | eid_2-s2.0-84937762014 | - |
dc.identifier.hkuros | 251744 | - |
dc.identifier.volume | 6 | - |
dc.identifier.spage | 322 | - |
dc.identifier.epage | 333 | - |
dc.identifier.eissn | 1674-8018 | - |
dc.identifier.isi | WOS:000354054700003 | - |
dc.identifier.issnl | 1674-800X | - |