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- Publisher Website: 10.1186/1471-2334-14-470
- Scopus: eid_2-s2.0-84906825630
- PMID: 25169022
- WOS: WOS:000341209000001
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Article: Fatal anti-aquaporin-4 seropositive neuromyelitis optica spectrum disorder in tuberculosis
Title | Fatal anti-aquaporin-4 seropositive neuromyelitis optica spectrum disorder in tuberculosis |
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Authors | |
Keywords | Anti-aquaporin-4 antibody Neuromyelitis optica Tuberculosis |
Issue Date | 2014 |
Citation | BMC Infectious Diseases, 2014, v. 14, p. 470 How to Cite? |
Abstract | © 2014 Sridhar et al.; licensee BioMed Central Ltd.Background: Neuromyelitis optica (NMO) is an autoimmune inflammatory condition of the central nervous system that is characterized by circulating anti-aquaporin-4 antibodies, transverse myelitis and optic neuritis. NMO spectrum disorders are rarely reported in patients with active pulmonary tuberculosis (TB). We report a fatal case of anti-aquaporin-4 antibody positive NMO spectrum disorder in a patient who was receiving treatment for pulmonary tuberculosis. Case presentation: A previously healthy 42-year-old Chinese man was diagnosed with smear positive pulmonary tuberculosis. After one month of anti-tuberculosis treatment, he presented with acute generalized weakness and rapid neurological deterioration. Spinal imaging and anti-aquaporin-4 antibody positivity established a diagnosis of neuromyelitis optica spectrum disorder. Conclusion: This is the first reported case of anti-aquaporin-4 antibody-positive NMO spectrum disorder in a patient with active tuberculosis. It shows the usefulness of testing for anti-aquaporin-4 antibodies while evaluating neurological deterioration in patients with tuberculosis. The literature on the rare association between NMO spectrum disorders and TB is reviewed. |
Persistent Identifier | http://hdl.handle.net/10722/216539 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Sridhar, S | - |
dc.contributor.author | Chan, JFW | - |
dc.contributor.author | Yuen, KY | - |
dc.date.accessioned | 2015-09-18T05:30:55Z | - |
dc.date.available | 2015-09-18T05:30:55Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | BMC Infectious Diseases, 2014, v. 14, p. 470 | - |
dc.identifier.uri | http://hdl.handle.net/10722/216539 | - |
dc.description.abstract | © 2014 Sridhar et al.; licensee BioMed Central Ltd.Background: Neuromyelitis optica (NMO) is an autoimmune inflammatory condition of the central nervous system that is characterized by circulating anti-aquaporin-4 antibodies, transverse myelitis and optic neuritis. NMO spectrum disorders are rarely reported in patients with active pulmonary tuberculosis (TB). We report a fatal case of anti-aquaporin-4 antibody positive NMO spectrum disorder in a patient who was receiving treatment for pulmonary tuberculosis. Case presentation: A previously healthy 42-year-old Chinese man was diagnosed with smear positive pulmonary tuberculosis. After one month of anti-tuberculosis treatment, he presented with acute generalized weakness and rapid neurological deterioration. Spinal imaging and anti-aquaporin-4 antibody positivity established a diagnosis of neuromyelitis optica spectrum disorder. Conclusion: This is the first reported case of anti-aquaporin-4 antibody-positive NMO spectrum disorder in a patient with active tuberculosis. It shows the usefulness of testing for anti-aquaporin-4 antibodies while evaluating neurological deterioration in patients with tuberculosis. The literature on the rare association between NMO spectrum disorders and TB is reviewed. | - |
dc.language | eng | - |
dc.relation.ispartof | BMC Infectious Diseases | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Anti-aquaporin-4 antibody | - |
dc.subject | Neuromyelitis optica | - |
dc.subject | Tuberculosis | - |
dc.title | Fatal anti-aquaporin-4 seropositive neuromyelitis optica spectrum disorder in tuberculosis | - |
dc.type | Article | - |
dc.identifier.email | Sridhar, S: sid8998@hku.hk | - |
dc.identifier.email | Chan, JFW: jfwchan@hku.hk | - |
dc.identifier.email | Yuen, KY: kyyuen@hkucc.hku.hk | - |
dc.identifier.authority | Chan, JFW=rp01736 | - |
dc.identifier.authority | Yuen, KY=rp00366 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1186/1471-2334-14-470 | - |
dc.identifier.pmid | 25169022 | - |
dc.identifier.scopus | eid_2-s2.0-84906825630 | - |
dc.identifier.hkuros | 253232 | - |
dc.identifier.volume | 14 | - |
dc.identifier.spage | 470 | - |
dc.identifier.epage | 470 | - |
dc.identifier.eissn | 1471-2334 | - |
dc.identifier.isi | WOS:000341209000001 | - |
dc.identifier.issnl | 1471-2334 | - |