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Conference Paper: In situ photopolymerizable drug delivery matrix: Tensile property, degradation products, tissue adhesiveness, and efficacy in vivo
| Title | In situ photopolymerizable drug delivery matrix: Tensile property, degradation products, tissue adhesiveness, and efficacy in vivo |
|---|---|
| Authors | |
| Issue Date | 2004 |
| Citation | Transactions - 7th World Biomaterials Congress, 2004, p. 616 How to Cite? |
| Abstract | The assessment of interpenetrating (IPN) tensile property, degradation products, tissue adhesive strength, and efficacy of released in situ photopolymerizable drug delivery, was described. The IPNs were photocured in a mold held directly on freshly isolated rat epidermis, dermis, or latissimus dorsi muscle. IPNs exhibited an enhanced elasticity and strength when compared to glutaraldehyde-fixed gelatin hydrogels. The nature of IPN degradation products was independent of the type of gelatin backbone modification. The results show that IPNs have potential as biodegradabe/compatible, tailorable, in situ delivery matrices for therapeutic drugs and cells in wound management and tissue scaffolding. |
| Persistent Identifier | http://hdl.handle.net/10722/216177 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kao, W. J. | - |
| dc.contributor.author | Zilinski, J. L. | - |
| dc.contributor.author | Martinez-Diaz, G. J. | - |
| dc.contributor.author | Nelson, D. | - |
| dc.contributor.author | Witte, R. | - |
| dc.date.accessioned | 2015-08-25T10:22:13Z | - |
| dc.date.available | 2015-08-25T10:22:13Z | - |
| dc.date.issued | 2004 | - |
| dc.identifier.citation | Transactions - 7th World Biomaterials Congress, 2004, p. 616 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/216177 | - |
| dc.description.abstract | The assessment of interpenetrating (IPN) tensile property, degradation products, tissue adhesive strength, and efficacy of released in situ photopolymerizable drug delivery, was described. The IPNs were photocured in a mold held directly on freshly isolated rat epidermis, dermis, or latissimus dorsi muscle. IPNs exhibited an enhanced elasticity and strength when compared to glutaraldehyde-fixed gelatin hydrogels. The nature of IPN degradation products was independent of the type of gelatin backbone modification. The results show that IPNs have potential as biodegradabe/compatible, tailorable, in situ delivery matrices for therapeutic drugs and cells in wound management and tissue scaffolding. | - |
| dc.language | eng | - |
| dc.relation.ispartof | Transactions - 7th World Biomaterials Congress | - |
| dc.title | In situ photopolymerizable drug delivery matrix: Tensile property, degradation products, tissue adhesiveness, and efficacy in vivo | - |
| dc.type | Conference_Paper | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.scopus | eid_2-s2.0-13844298172 | - |
| dc.identifier.spage | 616 | - |
| dc.identifier.epage | 616 | - |