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Conference Paper: Multifunctional protein-based matrix for drug delivery and wound management
Title | Multifunctional protein-based matrix for drug delivery and wound management |
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Authors | |
Keywords | Protein modification Mechanical property Interpenetrating networks Biomaterials |
Issue Date | 2003 |
Citation | Materials Science Forum, 2003, v. 426-432, n. 4, p. 3145-3150 How to Cite? |
Abstract | Biological systems operate at a multi-component and hierarchical scale that requires the participation of specific cues (i.e., cells, proteins) orchestrated in a precise spatial and temporal fashion. Our objective is to establish a robust and multifunctional material construct that provides multiple growth and developmental signals to enhance, cellular function and to assist in the re-establishment of normal tissue architecture. We developed an in situ photopolymerized interpenetrating network (IPN) system that consists of (i) gelatin modified with polyanions and/or polyethyleneglycols (PEG) and (ii) PEG-diacrylate at various ratios. Immobilized and soluble factors were incorporated within the IPN to provide various biological signals in modulating cellular behavior. The effect of formulation on IPN chemicophysical properties, drug release kinetics, in vitro cell interaction thereof, and in vivo host response were quantified. |
Persistent Identifier | http://hdl.handle.net/10722/216167 |
ISSN | 2023 SCImago Journal Rankings: 0.195 |
DC Field | Value | Language |
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dc.contributor.author | Kao, W. J. | - |
dc.contributor.author | Burmania, J. | - |
dc.contributor.author | Li, J. | - |
dc.contributor.author | Einerson, N. | - |
dc.contributor.author | Witte, R. | - |
dc.contributor.author | Stevens, K. | - |
dc.contributor.author | Nelson, D. | - |
dc.contributor.author | Martinez-Diaz, G. | - |
dc.date.accessioned | 2015-08-25T10:22:08Z | - |
dc.date.available | 2015-08-25T10:22:08Z | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Materials Science Forum, 2003, v. 426-432, n. 4, p. 3145-3150 | - |
dc.identifier.issn | 0255-5476 | - |
dc.identifier.uri | http://hdl.handle.net/10722/216167 | - |
dc.description.abstract | Biological systems operate at a multi-component and hierarchical scale that requires the participation of specific cues (i.e., cells, proteins) orchestrated in a precise spatial and temporal fashion. Our objective is to establish a robust and multifunctional material construct that provides multiple growth and developmental signals to enhance, cellular function and to assist in the re-establishment of normal tissue architecture. We developed an in situ photopolymerized interpenetrating network (IPN) system that consists of (i) gelatin modified with polyanions and/or polyethyleneglycols (PEG) and (ii) PEG-diacrylate at various ratios. Immobilized and soluble factors were incorporated within the IPN to provide various biological signals in modulating cellular behavior. The effect of formulation on IPN chemicophysical properties, drug release kinetics, in vitro cell interaction thereof, and in vivo host response were quantified. | - |
dc.language | eng | - |
dc.relation.ispartof | Materials Science Forum | - |
dc.subject | Protein modification | - |
dc.subject | Mechanical property | - |
dc.subject | Interpenetrating networks | - |
dc.subject | Biomaterials | - |
dc.title | Multifunctional protein-based matrix for drug delivery and wound management | - |
dc.type | Conference_Paper | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.scopus | eid_2-s2.0-0037662085 | - |
dc.identifier.volume | 426-432 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 3145 | - |
dc.identifier.epage | 3150 | - |
dc.identifier.issnl | 0255-5476 | - |