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- Publisher Website: 10.1163/15685620260449741
- Scopus: eid_2-s2.0-0036962734
- PMID: 12555901
- WOS: WOS:000181070300006
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Article: In vivo biocompatibility of gelatin-based hydrogels and interpenetrating networks
Title | In vivo biocompatibility of gelatin-based hydrogels and interpenetrating networks |
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Authors | |
Keywords | Subcutaneous cage implant Dexamethasone Glutaraldehyde Leukocytes Polyethyleneglycol |
Issue Date | 2002 |
Citation | Journal of Biomaterials Science, Polymer Edition, 2002, v. 13, n. 12, p. 1353-1366 How to Cite? |
Abstract | The in vivo host response to two gelatin-based hydrogel systems of varying crosslinking modalities and loaded with the anti-inflammatory agent dexamethasone sodium phosphate was investigated. Either gelatin was chemically crosslinked with glutaraldehyde, or polyethyleneglycol diacrylate was photopolymerized around gelatin to form interpenetrating networks. The subcutaneous cage implant system was utilized to determine differential leukocyte concentrations in the inflammatory exudate surrounding the materials as indices for biocompatibility and drug efficacy in vivo. Most of the crosslinked gelatin-based materials, either via glutaraldehyde fixation or interpenetrating network formation, elicited stronger inflammatory responses than either of the starting materials, gelatin and polyethyleneglycol diacrylate. In general, dexamethasone delayed and intensified the inflammatory response. The loss of material mass did not correlate directly with the degree of cellular inflammatory response, but increased with longer implantation time and decreased with more extensive fixation. |
Persistent Identifier | http://hdl.handle.net/10722/216162 |
ISSN | 2023 Impact Factor: 3.6 2023 SCImago Journal Rankings: 0.595 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Stevens, Kelly R. | - |
dc.contributor.author | Einerson, Nicole J. | - |
dc.contributor.author | Burmania, Jeanine A. | - |
dc.contributor.author | Kao, Weiyuan John | - |
dc.date.accessioned | 2015-08-25T10:22:06Z | - |
dc.date.available | 2015-08-25T10:22:06Z | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Journal of Biomaterials Science, Polymer Edition, 2002, v. 13, n. 12, p. 1353-1366 | - |
dc.identifier.issn | 0920-5063 | - |
dc.identifier.uri | http://hdl.handle.net/10722/216162 | - |
dc.description.abstract | The in vivo host response to two gelatin-based hydrogel systems of varying crosslinking modalities and loaded with the anti-inflammatory agent dexamethasone sodium phosphate was investigated. Either gelatin was chemically crosslinked with glutaraldehyde, or polyethyleneglycol diacrylate was photopolymerized around gelatin to form interpenetrating networks. The subcutaneous cage implant system was utilized to determine differential leukocyte concentrations in the inflammatory exudate surrounding the materials as indices for biocompatibility and drug efficacy in vivo. Most of the crosslinked gelatin-based materials, either via glutaraldehyde fixation or interpenetrating network formation, elicited stronger inflammatory responses than either of the starting materials, gelatin and polyethyleneglycol diacrylate. In general, dexamethasone delayed and intensified the inflammatory response. The loss of material mass did not correlate directly with the degree of cellular inflammatory response, but increased with longer implantation time and decreased with more extensive fixation. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Biomaterials Science, Polymer Edition | - |
dc.subject | Subcutaneous cage implant | - |
dc.subject | Dexamethasone | - |
dc.subject | Glutaraldehyde | - |
dc.subject | Leukocytes | - |
dc.subject | Polyethyleneglycol | - |
dc.title | In vivo biocompatibility of gelatin-based hydrogels and interpenetrating networks | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1163/15685620260449741 | - |
dc.identifier.pmid | 12555901 | - |
dc.identifier.scopus | eid_2-s2.0-0036962734 | - |
dc.identifier.volume | 13 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 1353 | - |
dc.identifier.epage | 1366 | - |
dc.identifier.isi | WOS:000181070300006 | - |
dc.identifier.issnl | 0920-5063 | - |