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- Publisher Website: 10.1007/978-4-431-54841-6_30
- Scopus: eid_2-s2.0-84943613292
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Book Chapter: Glycopeptide/Glycoprotein Synthesis
Title | Glycopeptide/Glycoprotein Synthesis |
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Authors | |
Keywords | Chemical synthesis Chemoenzymatic Glycoproteins Native chemical ligation Serine/threonine ligation Solid-Phase peptide synthesis |
Issue Date | 2015 |
Publisher | Springer Japan |
Citation | Glycopeptide/Glycoprotein Synthesis. In Naoyuki Taniguchi ... (et al.) (Eds.), Glycoscience: Biology and Medicine, p. 323-330. Tokyo: Springer Japan, 2015 How to Cite? |
Abstract | Protein glycosylation has dramatically enriched both the functional and structural diversity of proteins in mammals. Due to the non-template biosynthesis of glycoproteins in the nature, glycoproteins always exist as heterogeneous mixtures with different glycan structures, which have complicated the isolation of pure and well-defined glycoforms for detailed mechanistic and functional studies. Over the past years, different strategies including chemical and chemoenzymatic methods have been developed for obtaining the homogenous glycoproteins, which will offer new opportunities to conduct an extensive assessment of relationship between the structure and function of glycoproteins and to reveal the biological role of the individual oligosaccharide on a glycoprotein for the evolution and development of cells. This chapter gives insight into the recent progress in the development of chemical and chemoenzymatic synthesis of homogenous glycoproteins including native chemical ligation, serine/threonine ligation, and chemoenzymatic glycoprotein remodeling. Examples are selected to demonstrate successful applications of synthetic strategies developed so far. |
Persistent Identifier | http://hdl.handle.net/10722/216014 |
ISBN |
DC Field | Value | Language |
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dc.contributor.author | Xu, C | - |
dc.contributor.author | Li, XC | - |
dc.date.accessioned | 2015-08-21T13:48:29Z | - |
dc.date.available | 2015-08-21T13:48:29Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Glycopeptide/Glycoprotein Synthesis. In Naoyuki Taniguchi ... (et al.) (Eds.), Glycoscience: Biology and Medicine, p. 323-330. Tokyo: Springer Japan, 2015 | - |
dc.identifier.isbn | 9784431548423 | - |
dc.identifier.uri | http://hdl.handle.net/10722/216014 | - |
dc.description.abstract | Protein glycosylation has dramatically enriched both the functional and structural diversity of proteins in mammals. Due to the non-template biosynthesis of glycoproteins in the nature, glycoproteins always exist as heterogeneous mixtures with different glycan structures, which have complicated the isolation of pure and well-defined glycoforms for detailed mechanistic and functional studies. Over the past years, different strategies including chemical and chemoenzymatic methods have been developed for obtaining the homogenous glycoproteins, which will offer new opportunities to conduct an extensive assessment of relationship between the structure and function of glycoproteins and to reveal the biological role of the individual oligosaccharide on a glycoprotein for the evolution and development of cells. This chapter gives insight into the recent progress in the development of chemical and chemoenzymatic synthesis of homogenous glycoproteins including native chemical ligation, serine/threonine ligation, and chemoenzymatic glycoprotein remodeling. Examples are selected to demonstrate successful applications of synthetic strategies developed so far. | - |
dc.language | eng | - |
dc.publisher | Springer Japan | - |
dc.relation.ispartof | Glycoscience: Biology and Medicine | - |
dc.subject | Chemical synthesis | - |
dc.subject | Chemoenzymatic | - |
dc.subject | Glycoproteins | - |
dc.subject | Native chemical ligation | - |
dc.subject | Serine/threonine ligation | - |
dc.subject | Solid-Phase peptide synthesis | - |
dc.title | Glycopeptide/Glycoprotein Synthesis | - |
dc.type | Book_Chapter | - |
dc.identifier.email | Li, XC: xuechenl@hku.hk | - |
dc.identifier.authority | Li, XC=rp00742 | - |
dc.identifier.doi | 10.1007/978-4-431-54841-6_30 | - |
dc.identifier.scopus | eid_2-s2.0-84943613292 | - |
dc.identifier.hkuros | 247971 | - |
dc.identifier.spage | 323 | - |
dc.identifier.epage | 330 | - |
dc.publisher.place | Tokyo | - |