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- Publisher Website: 10.1039/C4DT02814G
- Scopus: eid_2-s2.0-84916613829
- PMID: 25376598
- WOS: WOS:000346412500001
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Article: Metallomic and metalloproteomic strategies in elucidating the molecular mechanisms of metallodrugs
Title | Metallomic and metalloproteomic strategies in elucidating the molecular mechanisms of metallodrugs |
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Authors | |
Issue Date | 2015 |
Publisher | Royal Society of Chemistry. |
Citation | Dalton Transactions, 2015, v. 44 n. 2, p. 437-447 How to Cite? |
Abstract | Metals play a critical role in life processes, and metal-based drugs nowadays have been commonly used for therapeutic and diagnostic purposes. However, severe side-effects and acquired drug resistance are the major issues needing to be resolved prior to more effective metallodrugs being developed, which requires a full understanding of the underlying molecular mechanisms. Metallomic and metalloproteomic approaches have received growing attention and have been implemented in inorganic medicinal chemistry and chemical biology in the endeavor to expand our knowledge of the pharmacological profiles, potential targets and functional pathways of metallodrugs. This perspective summarizes some recent progress in using metallomic and metalloproteomic strategies to elucidate the mechanisms of action of representative anticancer and antimicrobial metal-based drugs and agents. |
Persistent Identifier | http://hdl.handle.net/10722/215151 |
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 0.697 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | WANG, Y | - |
dc.contributor.author | WANG, H | - |
dc.contributor.author | Li, H | - |
dc.contributor.author | Sun, H | - |
dc.date.accessioned | 2015-08-21T13:16:10Z | - |
dc.date.available | 2015-08-21T13:16:10Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Dalton Transactions, 2015, v. 44 n. 2, p. 437-447 | - |
dc.identifier.issn | 1477-9226 | - |
dc.identifier.uri | http://hdl.handle.net/10722/215151 | - |
dc.description.abstract | Metals play a critical role in life processes, and metal-based drugs nowadays have been commonly used for therapeutic and diagnostic purposes. However, severe side-effects and acquired drug resistance are the major issues needing to be resolved prior to more effective metallodrugs being developed, which requires a full understanding of the underlying molecular mechanisms. Metallomic and metalloproteomic approaches have received growing attention and have been implemented in inorganic medicinal chemistry and chemical biology in the endeavor to expand our knowledge of the pharmacological profiles, potential targets and functional pathways of metallodrugs. This perspective summarizes some recent progress in using metallomic and metalloproteomic strategies to elucidate the mechanisms of action of representative anticancer and antimicrobial metal-based drugs and agents. | - |
dc.language | eng | - |
dc.publisher | Royal Society of Chemistry. | - |
dc.relation.ispartof | Dalton Transactions | - |
dc.title | Metallomic and metalloproteomic strategies in elucidating the molecular mechanisms of metallodrugs | - |
dc.type | Article | - |
dc.identifier.email | Li, H: hylichem@hku.hk | - |
dc.identifier.email | Sun, H: hsun@hku.hk | - |
dc.identifier.authority | Sun, H=rp00777 | - |
dc.identifier.doi | 10.1039/C4DT02814G | - |
dc.identifier.pmid | 25376598 | - |
dc.identifier.scopus | eid_2-s2.0-84916613829 | - |
dc.identifier.hkuros | 247651 | - |
dc.identifier.volume | 44 | - |
dc.identifier.spage | 437 | - |
dc.identifier.epage | 447 | - |
dc.identifier.eissn | 1477-9234 | - |
dc.identifier.isi | WOS:000346412500001 | - |
dc.identifier.issnl | 1477-9226 | - |