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Article: Preventive Treatment with Ketamine attenuates the ischaemia-reperfusion response in a chronic postischaemia pain model

TitlePreventive Treatment with Ketamine attenuates the ischaemia-reperfusion response in a chronic postischaemia pain model
Authors
Issue Date2015
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/oximed/
Citation
Oxidative Medicine and Cellular Longevity, 2015, v. 2015, article no. 380403 How to Cite?
AbstractIschemia and inflammation may be pathophysiological mechanisms of complex regional pain syndrome (CRPS). Ketamine has proposed anti-inflammatory effects and has been used for treating CRPS. This study aimed to evaluate anti-inflammatory and analgesic effects of ketamine after ischaemia-reperfusion injury in a chronic postischaemia pain (CPIP) model of CRPS-I. Using this model, ischemia was induced in the hindlimbs of male Sprague-Dawley rats. Ketamine, methylprednisolone, or saline was administered immediately after reperfusion. Physical effects, (oedema, temperature, and mechanical and cold allodynia) in the bilateral hindpaws, were assessed from 48 hours after reperfusion. Fewer (56%) rats in the ketamine group developed CPIP at the 48th hour after reperfusion (nonsignificant). Ketamine treated rats showed a significantly lower temperature in the ischaemic hindpaw compared to saline (P < 0.01) and methylprednisolone (P < 0.05) groups. Mechanical and cold allodynia were significantly lower in the ischaemic side in the ketamine group (P < 0.05). Proinflammatory cytokines TNF-α and IL-2 were significantly lower at the 48th hour after reperfusion in ketamine and methylprednisolone groups, compared to saline (all P < 0.05). In conclusion, immediate administration of ketamine after an ischaemia-reperfusion injury can alleviate pain and inflammation in the CPIP model and has potential to treat postischaemic pain.
Persistent Identifierhttp://hdl.handle.net/10722/215076
ISSN
2019 Impact Factor: 5.076
2015 SCImago Journal Rankings: 1.503
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiman, S-
dc.contributor.authorCheung, CW-
dc.contributor.authorWong, KL-
dc.contributor.authorTai, W-
dc.contributor.authorQiu, Q-
dc.contributor.authorNg, KF-
dc.contributor.authorChoi, SW-
dc.contributor.authorIrwin, M-
dc.date.accessioned2015-08-21T12:24:53Z-
dc.date.available2015-08-21T12:24:53Z-
dc.date.issued2015-
dc.identifier.citationOxidative Medicine and Cellular Longevity, 2015, v. 2015, article no. 380403-
dc.identifier.issn1942-0900-
dc.identifier.urihttp://hdl.handle.net/10722/215076-
dc.description.abstractIschemia and inflammation may be pathophysiological mechanisms of complex regional pain syndrome (CRPS). Ketamine has proposed anti-inflammatory effects and has been used for treating CRPS. This study aimed to evaluate anti-inflammatory and analgesic effects of ketamine after ischaemia-reperfusion injury in a chronic postischaemia pain (CPIP) model of CRPS-I. Using this model, ischemia was induced in the hindlimbs of male Sprague-Dawley rats. Ketamine, methylprednisolone, or saline was administered immediately after reperfusion. Physical effects, (oedema, temperature, and mechanical and cold allodynia) in the bilateral hindpaws, were assessed from 48 hours after reperfusion. Fewer (56%) rats in the ketamine group developed CPIP at the 48th hour after reperfusion (nonsignificant). Ketamine treated rats showed a significantly lower temperature in the ischaemic hindpaw compared to saline (P < 0.01) and methylprednisolone (P < 0.05) groups. Mechanical and cold allodynia were significantly lower in the ischaemic side in the ketamine group (P < 0.05). Proinflammatory cytokines TNF-α and IL-2 were significantly lower at the 48th hour after reperfusion in ketamine and methylprednisolone groups, compared to saline (all P < 0.05). In conclusion, immediate administration of ketamine after an ischaemia-reperfusion injury can alleviate pain and inflammation in the CPIP model and has potential to treat postischaemic pain.-
dc.languageeng-
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/oximed/-
dc.relation.ispartofOxidative Medicine and Cellular Longevity-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titlePreventive Treatment with Ketamine attenuates the ischaemia-reperfusion response in a chronic postischaemia pain model-
dc.typeArticle-
dc.identifier.emailCheung, CW: cheucw@hku.hk-
dc.identifier.emailWong, KL: wongeric@hku.hk-
dc.identifier.emailNg, KF: jkfng@hku.hk-
dc.identifier.emailChoi, SW: htswchoi@hku.hk-
dc.identifier.emailIrwin, M: mgirwin@hku.hk-
dc.identifier.authorityCheung, CW=rp00244-
dc.identifier.authorityNg, KF=rp00544-
dc.identifier.authorityChoi, SW=rp02552-
dc.identifier.authorityIrwin, M=rp00390-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2015/380403-
dc.identifier.pmid26161236-
dc.identifier.pmcidPMC4487903-
dc.identifier.scopuseid_2-s2.0-84934300390-
dc.identifier.hkuros249417-
dc.identifier.volume2015-
dc.identifier.spagearticle no. 380403-
dc.identifier.epagearticle no. 380403-
dc.identifier.isiWOS:000357820500001-
dc.publisher.placeUnited States-

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