File Download
There are no files associated with this item.
Supplementary
-
Citations:
- Appears in Collections:
Conference Paper: In vitro evaluation of novel electrospun oxide-scaffold biocomposites
Title | In vitro evaluation of novel electrospun oxide-scaffold biocomposites |
---|---|
Authors | |
Keywords | Biomaterials Bone repair Composites Polymers Scaffold |
Issue Date | 2014 |
Publisher | International Association for Dental Research. |
Citation | The 2014 IADR/PER Congress, Dubrovnik, Croatia, 10-13 September 2014. How to Cite? |
Abstract | OBJECTIVE: The study of this in vitro study was to evaluate the biological performance of several novel oxides-loaded poly(lactic-L-glycolic acid) (PLLA) scaffold biocomposites, which were fabricated by electrospinning method, to demonstrate their use in bone tissue engineering. METHOD: Silicon dioxide (SiO2), Zirconium dioxide (ZrO2), Titanium dioxide (TiO2) and Hafnium dioxide (HfO2) conjugated with PLLA were developed and fabricated by electrospinning the biocomposite scaffolds, namely PLLA/SiO2, PLLA/ZrO2, PLLA/TiO2, and PLLA/HfO2. These biocomposite were characterized by SEM and EDX analyses. In vitro studies such as biomineralization, protein absorption, cytotoxicity were also carried out. RESULT: The scaffold possessed a porous nature with pore dimensions suitable for cell infiltration and colonization. The presence of zirconia and hafnia in the PLLA/ZrO2 and PLLA/HfO2 scaffold increased protein adsorption and biomineralization properties. The PLLA/ZrO2 and PLLA/HfO2 scaffold were also found to be non-toxic to osteoblast MC3T3-E1 cells. CONCLUSION: The novel electrospun PLLA/oxide scaffold biocomposites harbor the desired features such as biocompatibility and porous structure to serve as template for bone tissue engineering. In particular, PLLA/ZrO2 and PLLA/HfO2 are the highest potential candidates to be used for bone tissue engineering. |
Persistent Identifier | http://hdl.handle.net/10722/213787 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tsoi, JKH | - |
dc.contributor.author | Chan, K | - |
dc.contributor.author | Wong, RWK | - |
dc.date.accessioned | 2015-08-18T03:15:32Z | - |
dc.date.available | 2015-08-18T03:15:32Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | The 2014 IADR/PER Congress, Dubrovnik, Croatia, 10-13 September 2014. | - |
dc.identifier.uri | http://hdl.handle.net/10722/213787 | - |
dc.description.abstract | OBJECTIVE: The study of this in vitro study was to evaluate the biological performance of several novel oxides-loaded poly(lactic-L-glycolic acid) (PLLA) scaffold biocomposites, which were fabricated by electrospinning method, to demonstrate their use in bone tissue engineering. METHOD: Silicon dioxide (SiO2), Zirconium dioxide (ZrO2), Titanium dioxide (TiO2) and Hafnium dioxide (HfO2) conjugated with PLLA were developed and fabricated by electrospinning the biocomposite scaffolds, namely PLLA/SiO2, PLLA/ZrO2, PLLA/TiO2, and PLLA/HfO2. These biocomposite were characterized by SEM and EDX analyses. In vitro studies such as biomineralization, protein absorption, cytotoxicity were also carried out. RESULT: The scaffold possessed a porous nature with pore dimensions suitable for cell infiltration and colonization. The presence of zirconia and hafnia in the PLLA/ZrO2 and PLLA/HfO2 scaffold increased protein adsorption and biomineralization properties. The PLLA/ZrO2 and PLLA/HfO2 scaffold were also found to be non-toxic to osteoblast MC3T3-E1 cells. CONCLUSION: The novel electrospun PLLA/oxide scaffold biocomposites harbor the desired features such as biocompatibility and porous structure to serve as template for bone tissue engineering. In particular, PLLA/ZrO2 and PLLA/HfO2 are the highest potential candidates to be used for bone tissue engineering. | - |
dc.language | eng | - |
dc.publisher | International Association for Dental Research. | - |
dc.relation.ispartof | IADR/PER Congress | - |
dc.subject | Biomaterials | - |
dc.subject | Bone repair | - |
dc.subject | Composites | - |
dc.subject | Polymers | - |
dc.subject | Scaffold | - |
dc.title | In vitro evaluation of novel electrospun oxide-scaffold biocomposites | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Tsoi, JKH: jkhtsoi@hku.hk | - |
dc.identifier.email | Wong, RWK: fyoung@hku.hk | - |
dc.identifier.authority | Tsoi, JKH=rp01609 | - |
dc.identifier.authority | Wong, RWK=rp00038 | - |
dc.identifier.hkuros | 246345 | - |
dc.publisher.place | United States | - |