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- Publisher Website: 10.1016/j.diagmicrobio.2015.02.010
- Scopus: eid_2-s2.0-84929049764
- PMID: 25861872
- WOS: WOS:000355068800009
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Article: Prevalence and characterization of hybrid blaCTX-M among Escherichia coli isolates from livestock and other animals
Title | Prevalence and characterization of hybrid blaCTX-M among Escherichia coli isolates from livestock and other animals |
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Authors | |
Keywords | Antimicrobial resistance Cefotaxime resistance Enterobacteriaceae Extended-spectrum β-lactamases Molecular epidemiology Plasmids |
Issue Date | 2015 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio |
Citation | Diagnostic Microbiology and Infectious Disease, 2015, v. 82 n. 2, p. 148-153 How to Cite? |
Abstract | This study investigated 248 extended-spectrum β-lactamase-producing Escherichia coli isolates from 2012 to 2013 for hybrid blaCTX-M genes. blaCTX-M genes were detected in 228 isolates of which 14 isolates were hybrid blaCTX-M positive (6 blaCTX-M-123, 6 blaCTX-M-64, and 2 blaCTX-M-132). The 14 hybrid blaCTX-M–carrying isolates (8 from chickens, 2 each from pigs and cattle, 1 each from dog and rodent) were genetically diverse. All but 2 hybrid blaCTX-M were carried on IncI1 (5 blaCTX-M-123) and IncI2 (6 blaCTX-M-64 and one blaCTX-M-132) plasmids. Our IncI1 and IncI2 plasmids had pHNAH4-1–like and pHN1122-1–like restriction fragment length polymorphism patterns, respectively. Genetic relatedness of the plasmids to pHNAH4-1 and pHN1122-1 were confirmed by complete sequencing of 3 plasmids, pCTXM123_C0996, pCTXM64_C0967, and pCTXM132_P0421. Plasmids closely related to pHNAH4-1 and pHN1122-1 and carrying different blaCTX-M alleles have been reported from multiple geographic areas in China previously. The findings highlighted the wide dissemination of hybrid blaCTX-M variants in different parts of China. |
Persistent Identifier | http://hdl.handle.net/10722/213728 |
ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.626 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ho, PL | - |
dc.contributor.author | Liu, MCJ | - |
dc.contributor.author | Lo, WU | - |
dc.contributor.author | Lai, ELY | - |
dc.contributor.author | Lau, TCK | - |
dc.contributor.author | Law, OK | - |
dc.contributor.author | Chow, KH | - |
dc.date.accessioned | 2015-08-14T03:12:55Z | - |
dc.date.available | 2015-08-14T03:12:55Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Diagnostic Microbiology and Infectious Disease, 2015, v. 82 n. 2, p. 148-153 | - |
dc.identifier.issn | 0732-8893 | - |
dc.identifier.uri | http://hdl.handle.net/10722/213728 | - |
dc.description.abstract | This study investigated 248 extended-spectrum β-lactamase-producing Escherichia coli isolates from 2012 to 2013 for hybrid blaCTX-M genes. blaCTX-M genes were detected in 228 isolates of which 14 isolates were hybrid blaCTX-M positive (6 blaCTX-M-123, 6 blaCTX-M-64, and 2 blaCTX-M-132). The 14 hybrid blaCTX-M–carrying isolates (8 from chickens, 2 each from pigs and cattle, 1 each from dog and rodent) were genetically diverse. All but 2 hybrid blaCTX-M were carried on IncI1 (5 blaCTX-M-123) and IncI2 (6 blaCTX-M-64 and one blaCTX-M-132) plasmids. Our IncI1 and IncI2 plasmids had pHNAH4-1–like and pHN1122-1–like restriction fragment length polymorphism patterns, respectively. Genetic relatedness of the plasmids to pHNAH4-1 and pHN1122-1 were confirmed by complete sequencing of 3 plasmids, pCTXM123_C0996, pCTXM64_C0967, and pCTXM132_P0421. Plasmids closely related to pHNAH4-1 and pHN1122-1 and carrying different blaCTX-M alleles have been reported from multiple geographic areas in China previously. The findings highlighted the wide dissemination of hybrid blaCTX-M variants in different parts of China. | - |
dc.language | eng | - |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/diagmicrobio | - |
dc.relation.ispartof | Diagnostic Microbiology and Infectious Disease | - |
dc.rights | © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.subject | Antimicrobial resistance | - |
dc.subject | Cefotaxime resistance | - |
dc.subject | Enterobacteriaceae | - |
dc.subject | Extended-spectrum β-lactamases | - |
dc.subject | Molecular epidemiology | - |
dc.subject | Plasmids | - |
dc.title | Prevalence and characterization of hybrid blaCTX-M among Escherichia coli isolates from livestock and other animals | - |
dc.type | Article | - |
dc.identifier.email | Ho, PL: plho@hkucc.hku.hk | - |
dc.identifier.email | Liu, MCJ: melis@hku.hk | - |
dc.identifier.email | Lo, WU: stephlo@hku.hk | - |
dc.identifier.email | Lai, ELY: elylai@hku.hk | - |
dc.identifier.email | Chow, KH: khchowb@hku.hk | - |
dc.identifier.authority | Ho, PL=rp00406 | - |
dc.identifier.authority | Chow, KH=rp00370 | - |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1016/j.diagmicrobio.2015.02.010 | - |
dc.identifier.pmid | 25861872 | - |
dc.identifier.scopus | eid_2-s2.0-84929049764 | - |
dc.identifier.hkuros | 246367 | - |
dc.identifier.volume | 82 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 148 | - |
dc.identifier.epage | 153 | - |
dc.identifier.isi | WOS:000355068800009 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0732-8893 | - |