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Conference Paper: Lipid subclasses profiles and oxidative stress in aggressive periodontitis before and after treatment
Title | Lipid subclasses profiles and oxidative stress in aggressive periodontitis before and after treatment |
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Authors | |
Keywords | Genetic Periodontitis Lipid Aggressive Oxidative |
Issue Date | 2015 |
Publisher | Sage Publications, Inc. |
Citation | The 2015 IADR/AADR/CADR General Session & Exhibition, Boston, MA., 11-14 March 2015. In Journal of Dental Research Meeting Abstracts, 2015, v. 94 Spec. Iss. A, abstract no. 2028 How to Cite? |
Abstract | OBJECTIVES: The aim of this study was to investigate the lipid and oxidative stress profiles in aggressive periodontitis (AgP) patients, and to relate them to clinical variables and IL-6 genetic variants. METHODS: Twelve non-smoking Caucasian AgP patients selected based on their IL6 haplotypes underwent periodontal non-surgical and surgical treatment. Peripheral blood samples taken at baseline and at 6 different time-points after treatment were processed to determine lipid profiles (cholesterol, triglycerides, HDL and LDL subclasses) and oxidative stress markers (glutathione and total lipid hydroperoxide levels).RESULTS: HDL were the highest represented lipoproteins (38%), followed by IDL (26%), VLDL (20%), and LDL (16%). Among LDL, there was a prevalence of large LDL (LDL-1 and LDL-2), with a very small prevalence of small LDL. The lipid profile did not consistently change after treatment up to 3 months after surgery. Periodontal disease severity was associated with changes in concentrations of LDL (p=0.01), large IDL (p=0.04), medium IDL (p=0.004), small IDL (p<0.001), LDL-3 and LDL-2 and LDL-3 (p<0.001) and average LDL size (p<0.001). The IL6 haplotypes were associated with total cholesterol, triglycerides, HDL and LDL subclasses after adjusting for confounders (p<0.01). No associations were detected between clinical and genetic variables and oxidative stress parameters. CONCLUSIONS: Disease severity and IL6 haplotypes may influence lipid profiles in aggressive periodontitis. |
Description | ePoster: abstract no. 2028 |
Persistent Identifier | http://hdl.handle.net/10722/212169 |
ISSN | 2023 Impact Factor: 5.7 2023 SCImago Journal Rankings: 1.909 |
DC Field | Value | Language |
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dc.contributor.author | Nibali, L | - |
dc.contributor.author | Rizzo, M | - |
dc.contributor.author | Livolti, GL | - |
dc.contributor.author | D'Aiuto, F | - |
dc.contributor.author | Pelekos, G | - |
dc.contributor.author | Donos, N | - |
dc.date.accessioned | 2015-07-21T02:25:55Z | - |
dc.date.available | 2015-07-21T02:25:55Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | The 2015 IADR/AADR/CADR General Session & Exhibition, Boston, MA., 11-14 March 2015. In Journal of Dental Research Meeting Abstracts, 2015, v. 94 Spec. Iss. A, abstract no. 2028 | - |
dc.identifier.issn | 0022-0345 | - |
dc.identifier.uri | http://hdl.handle.net/10722/212169 | - |
dc.description | ePoster: abstract no. 2028 | - |
dc.description.abstract | OBJECTIVES: The aim of this study was to investigate the lipid and oxidative stress profiles in aggressive periodontitis (AgP) patients, and to relate them to clinical variables and IL-6 genetic variants. METHODS: Twelve non-smoking Caucasian AgP patients selected based on their IL6 haplotypes underwent periodontal non-surgical and surgical treatment. Peripheral blood samples taken at baseline and at 6 different time-points after treatment were processed to determine lipid profiles (cholesterol, triglycerides, HDL and LDL subclasses) and oxidative stress markers (glutathione and total lipid hydroperoxide levels).RESULTS: HDL were the highest represented lipoproteins (38%), followed by IDL (26%), VLDL (20%), and LDL (16%). Among LDL, there was a prevalence of large LDL (LDL-1 and LDL-2), with a very small prevalence of small LDL. The lipid profile did not consistently change after treatment up to 3 months after surgery. Periodontal disease severity was associated with changes in concentrations of LDL (p=0.01), large IDL (p=0.04), medium IDL (p=0.004), small IDL (p<0.001), LDL-3 and LDL-2 and LDL-3 (p<0.001) and average LDL size (p<0.001). The IL6 haplotypes were associated with total cholesterol, triglycerides, HDL and LDL subclasses after adjusting for confounders (p<0.01). No associations were detected between clinical and genetic variables and oxidative stress parameters. CONCLUSIONS: Disease severity and IL6 haplotypes may influence lipid profiles in aggressive periodontitis. | - |
dc.language | eng | - |
dc.publisher | Sage Publications, Inc. | - |
dc.relation.ispartof | Journal of Dental Research Meeting Abstracts | - |
dc.rights | Journal of Dental Research Meeting Abstracts. Copyright © Sage Publications, Inc. | - |
dc.subject | Genetic | - |
dc.subject | Periodontitis | - |
dc.subject | Lipid | - |
dc.subject | Aggressive | - |
dc.subject | Oxidative | - |
dc.title | Lipid subclasses profiles and oxidative stress in aggressive periodontitis before and after treatment | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Pelekos, G: george74@hku.hk | - |
dc.identifier.authority | Pelekos, G=rp01894 | - |
dc.identifier.hkuros | 245710 | - |
dc.identifier.volume | 94 | - |
dc.identifier.issue | Spec. Iss. A | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0022-0345 | - |