File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.3390/jcm3041105
- Scopus: eid_2-s2.0-85114273422
- WOS: WOS:000214758000003
Supplementary
- Citations:
- Appears in Collections:
Article: Clinical Potentials of Cardiomyocytes Derived from Patient-Specific Induced Pluripotent Stem Cells
Title | Clinical Potentials of Cardiomyocytes Derived from Patient-Specific Induced Pluripotent Stem Cells |
---|---|
Authors | |
Issue Date | 2014 |
Publisher | MDPI AG, Basel, Switzerland. |
Citation | Journal of Clinical Medicine, 2014, v. 3, p. 1105-1123 How to Cite? |
Abstract | The lack of appropriate human cardiomyocyte-based experimental platform has largely hindered the study of cardiac diseases and the development of therapeutic strategies. To date, somatic cells isolated from human subjects can be reprogramed into induced pluripotent stem cells (iPSCs) and subsequently differentiated into functional cardiomyocytes. This powerful reprogramming technology provides a novel in vitro human cell-based platform for the study of human hereditary cardiac disorders. The clinical potential of using iPSCs derived from patients with inherited cardiac disorders for therapeutic studies have been increasingly highlighted. In this review, the standard procedures for generating patient-specific iPSCs and the latest commonly used cardiac differentiation protocols will be outlined. Furthermore, the progress and limitations of current applications of iPSCs and iPSCs-derived cardiomyocytes in cell replacement therapy, disease modeling, drug-testing and toxicology studies will be discussed in detail. |
Persistent Identifier | http://hdl.handle.net/10722/211822 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ng, KM | - |
dc.contributor.author | LAW, CY | - |
dc.contributor.author | Tse, HF | - |
dc.date.accessioned | 2015-07-21T02:12:02Z | - |
dc.date.available | 2015-07-21T02:12:02Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Journal of Clinical Medicine, 2014, v. 3, p. 1105-1123 | - |
dc.identifier.uri | http://hdl.handle.net/10722/211822 | - |
dc.description.abstract | The lack of appropriate human cardiomyocyte-based experimental platform has largely hindered the study of cardiac diseases and the development of therapeutic strategies. To date, somatic cells isolated from human subjects can be reprogramed into induced pluripotent stem cells (iPSCs) and subsequently differentiated into functional cardiomyocytes. This powerful reprogramming technology provides a novel in vitro human cell-based platform for the study of human hereditary cardiac disorders. The clinical potential of using iPSCs derived from patients with inherited cardiac disorders for therapeutic studies have been increasingly highlighted. In this review, the standard procedures for generating patient-specific iPSCs and the latest commonly used cardiac differentiation protocols will be outlined. Furthermore, the progress and limitations of current applications of iPSCs and iPSCs-derived cardiomyocytes in cell replacement therapy, disease modeling, drug-testing and toxicology studies will be discussed in detail. | - |
dc.language | eng | - |
dc.publisher | MDPI AG, Basel, Switzerland. | - |
dc.relation.ispartof | Journal of Clinical Medicine | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Clinical Potentials of Cardiomyocytes Derived from Patient-Specific Induced Pluripotent Stem Cells | - |
dc.type | Article | - |
dc.identifier.email | Ng, KM: skykmng@hkucc.hku.hk | - |
dc.identifier.email | Tse, HF: hftse@hkucc.hku.hk | - |
dc.identifier.authority | Ng, KM=rp01670 | - |
dc.identifier.authority | Tse, HF=rp00428 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/jcm3041105 | - |
dc.identifier.scopus | eid_2-s2.0-85114273422 | - |
dc.identifier.hkuros | 245133 | - |
dc.identifier.volume | 3 | - |
dc.identifier.spage | 1105 | - |
dc.identifier.epage | 1123 | - |
dc.identifier.eissn | 2077-0383 | - |
dc.identifier.isi | WOS:000214758000003 | - |
dc.identifier.issnl | 2077-0383 | - |