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Article: Double-pulsed diffusional kurtosis imaging for the in vivo assessment of human brain microstructure
Title | Double-pulsed diffusional kurtosis imaging for the in vivo assessment of human brain microstructure |
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Authors | |
Keywords | Double-pulsed-field-gradient Human Kurtosis Microscopic anisotropy Multiple-wave-vector Non-Gaussian diffusion |
Issue Date | 2015 |
Publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg |
Citation | NeuroImage, 2015, v. 120, p. 371-381 How to Cite? |
Abstract | We have recently extended conventional single-pulsed-field-gradient (s-PFG) diffusional kurtosis imaging (DKI) to double-pulsed-field-gradient (d-PFG) diffusion MRI sequences, with a method known as double-pulsed DKI (DP-DKI). By virtue of a six-dimensional (6D) formulation for q-space, many of the results and insights of s-PFG DKI are generalized to those of DP-DKI. Owing to the fact that DP-DKI isolates the second order contributions to the d-PFG signal (i.e. second order in b-value), the 6D diffusional kurtosis encodes information beyond what is available from s-PFG sequences. Previously, we have demonstrated DP-DKI for in vivo mouse brain at 7 T, and it is the objective of this study to demonstrate the feasibility of DP-DKI at 3 T for the in vivo assessment of human brain microstructure. In addition, an example is given of how to utilize the additional information obtained from DP-DKI for the purpose of biophysical modeling. The relationship between a specific microscopic anisotropy metric estimated from DP-DKI and other recently proposed measures is also discussed. |
Persistent Identifier | http://hdl.handle.net/10722/211743 |
ISSN | 2023 Impact Factor: 4.7 2023 SCImago Journal Rankings: 2.436 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Hui, ESK | - |
dc.contributor.author | Jensen, JH | - |
dc.date.accessioned | 2015-07-21T02:09:47Z | - |
dc.date.available | 2015-07-21T02:09:47Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | NeuroImage, 2015, v. 120, p. 371-381 | - |
dc.identifier.issn | 1053-8119 | - |
dc.identifier.uri | http://hdl.handle.net/10722/211743 | - |
dc.description.abstract | We have recently extended conventional single-pulsed-field-gradient (s-PFG) diffusional kurtosis imaging (DKI) to double-pulsed-field-gradient (d-PFG) diffusion MRI sequences, with a method known as double-pulsed DKI (DP-DKI). By virtue of a six-dimensional (6D) formulation for q-space, many of the results and insights of s-PFG DKI are generalized to those of DP-DKI. Owing to the fact that DP-DKI isolates the second order contributions to the d-PFG signal (i.e. second order in b-value), the 6D diffusional kurtosis encodes information beyond what is available from s-PFG sequences. Previously, we have demonstrated DP-DKI for in vivo mouse brain at 7 T, and it is the objective of this study to demonstrate the feasibility of DP-DKI at 3 T for the in vivo assessment of human brain microstructure. In addition, an example is given of how to utilize the additional information obtained from DP-DKI for the purpose of biophysical modeling. The relationship between a specific microscopic anisotropy metric estimated from DP-DKI and other recently proposed measures is also discussed. | - |
dc.language | eng | - |
dc.publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg | - |
dc.relation.ispartof | NeuroImage | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Double-pulsed-field-gradient | - |
dc.subject | Human | - |
dc.subject | Kurtosis | - |
dc.subject | Microscopic anisotropy | - |
dc.subject | Multiple-wave-vector | - |
dc.subject | Non-Gaussian diffusion | - |
dc.title | Double-pulsed diffusional kurtosis imaging for the in vivo assessment of human brain microstructure | - |
dc.type | Article | - |
dc.identifier.email | Hui, ESK: edshui@hku.hk | - |
dc.identifier.authority | Hui, ESK=rp01832 | - |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1016/j.neuroimage.2015.07.013 | - |
dc.identifier.scopus | eid_2-s2.0-84938693747 | - |
dc.identifier.hkuros | 245844 | - |
dc.identifier.volume | 120 | - |
dc.identifier.spage | 371 | - |
dc.identifier.epage | 381 | - |
dc.identifier.isi | WOS:000362025000033 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1053-8119 | - |