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- Publisher Website: 10.1016/j.mri.2013.03.018
- Scopus: eid_2-s2.0-84883740913
- PMID: 23664679
- WOS: WOS:000324609000004
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Article: Parotid perfusion in nasopharyngeal carcinoma patients in early-to-intermediate stage after low-dose intensity-modulated radiotherapy: Evaluated by fat-saturated dynamic contrast-enhanced magnetic resonance imaging
Title | Parotid perfusion in nasopharyngeal carcinoma patients in early-to-intermediate stage after low-dose intensity-modulated radiotherapy: Evaluated by fat-saturated dynamic contrast-enhanced magnetic resonance imaging |
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Authors | |
Issue Date | 2013 |
Citation | Magnetic Resonance Imaging, 2013, v. 31, n. 8, p. 1278-1284 How to Cite? |
Abstract | Purpose: To investigate parotid perfusion in early-to-intermediate stage after parotid-sparing radiation dose using fat-saturated DCE-MRI, and to verify whether the perfusion alteration was related to radiation dose and the PSV. Methods and Materials: Thirty-two parotid glands from 16 consecutive patients with pathologically proven nasopharyngeal carcinoma treated by IMRT were examined. The parotid glands received a radiation dose of 28.9. ±. 3.9. Gy with a PSV of 43.1%. ±. 13.9%. Perfusion parameters were calculated using time-shifted Brix model from fat-saturated DCE-MRI data before (pre-RT) and in early-to-intermediate stage after (post-RT) IMRT. Paired t-test was used to evaluate perfusion changes, while Pearson's correlation test was used to examine perfusion dependency on radiation dose and PSV. For multiple comparisons Bonferroni correction was applied. Results: Successful fat saturation was achieved in 29 of 32 parotid glands. Compared with pre-RT, the post-RT parotid glands showed significantly higher A, peak enhancement, and wash-in slope, plus a lower Kel, suggesting a mixed effect of increased vascular permeability and acinar loss. Linear regression showed that peak enhancement was positively associated with radiation dose in post-RT parotid glands. Kel and slope were negatively associated with PSV, while time-to-peak was positively associated with PSV significantly. Conclusions: Our results suggest that time-shifted Brix model is feasible for quantifying parotid perfusion using DCE-MRI. The perfusion alterations in early-to-intermediate stage after IMRT might be related to a mixed effect of increased vascular permeability and acinar loss with dose and PSV dependencies. © 2013 Elsevier Inc. |
Persistent Identifier | http://hdl.handle.net/10722/210119 |
ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.647 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Cheng, Cheng Chieh | - |
dc.contributor.author | Chiu, Su Chin | - |
dc.contributor.author | Jen, Yee Min | - |
dc.contributor.author | Chang, Hing Chiu | - |
dc.contributor.author | Chung, Hsiao Wen | - |
dc.contributor.author | Liu, Yi Jui | - |
dc.contributor.author | Chiu, Hui Chu | - |
dc.contributor.author | Chen, Cheng Yu | - |
dc.contributor.author | Huang, Guo Shu | - |
dc.contributor.author | Juan, Chun Jung | - |
dc.date.accessioned | 2015-05-22T06:06:41Z | - |
dc.date.available | 2015-05-22T06:06:41Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Magnetic Resonance Imaging, 2013, v. 31, n. 8, p. 1278-1284 | - |
dc.identifier.issn | 0730-725X | - |
dc.identifier.uri | http://hdl.handle.net/10722/210119 | - |
dc.description.abstract | Purpose: To investigate parotid perfusion in early-to-intermediate stage after parotid-sparing radiation dose using fat-saturated DCE-MRI, and to verify whether the perfusion alteration was related to radiation dose and the PSV. Methods and Materials: Thirty-two parotid glands from 16 consecutive patients with pathologically proven nasopharyngeal carcinoma treated by IMRT were examined. The parotid glands received a radiation dose of 28.9. ±. 3.9. Gy with a PSV of 43.1%. ±. 13.9%. Perfusion parameters were calculated using time-shifted Brix model from fat-saturated DCE-MRI data before (pre-RT) and in early-to-intermediate stage after (post-RT) IMRT. Paired t-test was used to evaluate perfusion changes, while Pearson's correlation test was used to examine perfusion dependency on radiation dose and PSV. For multiple comparisons Bonferroni correction was applied. Results: Successful fat saturation was achieved in 29 of 32 parotid glands. Compared with pre-RT, the post-RT parotid glands showed significantly higher A, peak enhancement, and wash-in slope, plus a lower Kel, suggesting a mixed effect of increased vascular permeability and acinar loss. Linear regression showed that peak enhancement was positively associated with radiation dose in post-RT parotid glands. Kel and slope were negatively associated with PSV, while time-to-peak was positively associated with PSV significantly. Conclusions: Our results suggest that time-shifted Brix model is feasible for quantifying parotid perfusion using DCE-MRI. The perfusion alterations in early-to-intermediate stage after IMRT might be related to a mixed effect of increased vascular permeability and acinar loss with dose and PSV dependencies. © 2013 Elsevier Inc. | - |
dc.language | eng | - |
dc.relation.ispartof | Magnetic Resonance Imaging | - |
dc.title | Parotid perfusion in nasopharyngeal carcinoma patients in early-to-intermediate stage after low-dose intensity-modulated radiotherapy: Evaluated by fat-saturated dynamic contrast-enhanced magnetic resonance imaging | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.mri.2013.03.018 | - |
dc.identifier.pmid | 23664679 | - |
dc.identifier.scopus | eid_2-s2.0-84883740913 | - |
dc.identifier.volume | 31 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 1278 | - |
dc.identifier.epage | 1284 | - |
dc.identifier.eissn | 1873-5894 | - |
dc.identifier.isi | WOS:000324609000004 | - |
dc.identifier.issnl | 0730-725X | - |