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Article: Quantifying Silicone Oil Emulsification In Patients: Are We Only Seeing The Tip Of The Iceberg?

TitleQuantifying Silicone Oil Emulsification In Patients: Are We Only Seeing The Tip Of The Iceberg?
Authors
KeywordsSilicone oil
Emulsification
Coulter counter
Tamponade
Issue Date2015
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00417/index.htm
Citation
Graefe's Archive for Clinical and Experimental Ophthalmology, 2015, v. 253 n. 10, p. 1671-1675 How to Cite?
AbstractPurpose Emulsification of silicone oil in the eye is a difficult problem. In an effort to find an objective way to quantify emulsification, we used the Coulter principle to measure silicone oil emulsified droplets from the washings of a series of patients. Methods Aqueous washouts after silicone oil removal were obtained from nine patients (nine eyes). We used the Coulter counter Multisizer® 4 to obtain the size distribution of the oil droplets. Results Over 65 % of the emulsified silicone oil droplets in the clinical samples had a diameter smaller than is detectable by light microscopy (2 μm). The median size of the droplets was between 1.1 and 1.9 μm. Based on the Spearman’s correlation coefficient (r), there was a strong correlation between the number of the droplets that cannot be seen (between 1 and 2 μm) and those that can be seen (7–30 μm) (r = 0.817, p = 0.007). Conclusion Once emulsification was detected clinically in the anterior chamber, extensive emulsification would have already occurred in the posterior chamber, with most of the emulsified droplets that were too small in size to be seen on clinical examination. Ostwald ripening might explain why there were so many small droplets. The predominance of small droplets might account for some of the clinical complications associated with silicone oil use.
Persistent Identifierhttp://hdl.handle.net/10722/210004
ISSN
2023 Impact Factor: 2.4
2023 SCImago Journal Rankings: 1.014
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, YK-
dc.contributor.authorCheung, ND-
dc.contributor.authorChan, WSC-
dc.contributor.authorWong, DSH-
dc.date.accessioned2015-05-18T03:40:23Z-
dc.date.available2015-05-18T03:40:23Z-
dc.date.issued2015-
dc.identifier.citationGraefe's Archive for Clinical and Experimental Ophthalmology, 2015, v. 253 n. 10, p. 1671-1675-
dc.identifier.issn0721-832X-
dc.identifier.urihttp://hdl.handle.net/10722/210004-
dc.description.abstractPurpose Emulsification of silicone oil in the eye is a difficult problem. In an effort to find an objective way to quantify emulsification, we used the Coulter principle to measure silicone oil emulsified droplets from the washings of a series of patients. Methods Aqueous washouts after silicone oil removal were obtained from nine patients (nine eyes). We used the Coulter counter Multisizer® 4 to obtain the size distribution of the oil droplets. Results Over 65 % of the emulsified silicone oil droplets in the clinical samples had a diameter smaller than is detectable by light microscopy (2 μm). The median size of the droplets was between 1.1 and 1.9 μm. Based on the Spearman’s correlation coefficient (r), there was a strong correlation between the number of the droplets that cannot be seen (between 1 and 2 μm) and those that can be seen (7–30 μm) (r = 0.817, p = 0.007). Conclusion Once emulsification was detected clinically in the anterior chamber, extensive emulsification would have already occurred in the posterior chamber, with most of the emulsified droplets that were too small in size to be seen on clinical examination. Ostwald ripening might explain why there were so many small droplets. The predominance of small droplets might account for some of the clinical complications associated with silicone oil use.-
dc.languageeng-
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00417/index.htm-
dc.relation.ispartofGraefe's Archive for Clinical and Experimental Ophthalmology-
dc.rightsThe final publication is available at Springer via http://dx.doi.org/10.1007/s00417-014-2866-1-
dc.subjectSilicone oil-
dc.subjectEmulsification-
dc.subjectCoulter counter-
dc.subjectTamponade-
dc.titleQuantifying Silicone Oil Emulsification In Patients: Are We Only Seeing The Tip Of The Iceberg?-
dc.typeArticle-
dc.identifier.emailChan, YK: josephyk@connect.hku.hk-
dc.identifier.emailCheung, ND: dc555@hku.hk-
dc.identifier.emailChan, WSC: cath0320@hkucc.hku.hk-
dc.identifier.emailWong, DSH: shdwong@hku.hk-
dc.identifier.authorityChan, YK=rp02536-
dc.identifier.authorityCheung, ND=rp01752-
dc.identifier.authorityWong, DSH=rp00516-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00417-014-2866-1-
dc.identifier.pmid25418036-
dc.identifier.scopuseid_2-s2.0-84941878612-
dc.identifier.hkuros243292-
dc.identifier.volume253-
dc.identifier.issue10-
dc.identifier.spage1671-
dc.identifier.epage1675-
dc.identifier.isiWOS:000361397200006-
dc.publisher.placeGermany-
dc.identifier.issnl0721-832X-

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