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Article: Development Of Emulsification Resistant Heavier-than-water Tamponades Using High Molecular Weight Silicone Oil Polymers

TitleDevelopment Of Emulsification Resistant Heavier-than-water Tamponades Using High Molecular Weight Silicone Oil Polymers
Authors
KeywordsEmulsification
Ophthalmology
Retinal detachment
Silicone oil
Tamponade
Issue Date2015
PublisherSage Publications Ltd.. The Journal's web site is located at http://jba.sagepub.com/
Citation
Journal of Biomaterials Applications, 2015, v. 30 n. 2, p. 212-220 How to Cite?
AbstractPurpose: Developing new blends of heavier-than-water silicone oil tamponade agents containing high molecular weight polydimethylsiloxane polymer for use in vitreoretinal surgery. Materials and methods: The viscoelastic properties of heavier-than-water silicone oil blends (30.5% F6H8 + 69.5% polydimethylsiloxane) containing high molecular weight polymer additive at increasing concentrations were measured using a controlled-stress rheometer (TA Instruments Rheolyst AR 1000 N). Emulsification of the blends was induced using a sonication device and a pluronic surfactant as a strong emulsifier. The percentage emulsion area was photographed and measured using ImageJ software. In a second in vitro emulsification assessment, silicone oil blends were dispersed using a high shear homogenizer and the oil-in-water droplets were counted using a coulter counter particle analyser. Results: The addition of the high molecular weight polymer increased shear viscosity and viscoelasticity of the oil blends, which were measureable and to some extent predictable. The in vitro emulsification models produced contradictory results. This demonstrates the difficulty of designing and using in vitro models to evaluate the emulsification tendency of tamponade agents in vivo. Conclusion: Addition of a high molecular weight polymer to heavy silicone oil can increase the viscoelasticity. These findings might contribute to the development of emulsification resistant heavy silicone oils.
Persistent Identifierhttp://hdl.handle.net/10722/210001
ISSN
2023 Impact Factor: 2.3
2023 SCImago Journal Rankings: 0.473
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCaramoy, A-
dc.contributor.authorKearns, V-
dc.contributor.authorChan, YK-
dc.contributor.authorHagedorn, N-
dc.contributor.authorPoole, R-
dc.contributor.authorWong, DSH-
dc.contributor.authorFauser, S-
dc.contributor.authorKugler, W-
dc.contributor.authorKirchhof, B-
dc.contributor.authorWilliams, R-
dc.date.accessioned2015-05-18T03:40:23Z-
dc.date.available2015-05-18T03:40:23Z-
dc.date.issued2015-
dc.identifier.citationJournal of Biomaterials Applications, 2015, v. 30 n. 2, p. 212-220-
dc.identifier.issn0885-3282-
dc.identifier.urihttp://hdl.handle.net/10722/210001-
dc.description.abstractPurpose: Developing new blends of heavier-than-water silicone oil tamponade agents containing high molecular weight polydimethylsiloxane polymer for use in vitreoretinal surgery. Materials and methods: The viscoelastic properties of heavier-than-water silicone oil blends (30.5% F6H8 + 69.5% polydimethylsiloxane) containing high molecular weight polymer additive at increasing concentrations were measured using a controlled-stress rheometer (TA Instruments Rheolyst AR 1000 N). Emulsification of the blends was induced using a sonication device and a pluronic surfactant as a strong emulsifier. The percentage emulsion area was photographed and measured using ImageJ software. In a second in vitro emulsification assessment, silicone oil blends were dispersed using a high shear homogenizer and the oil-in-water droplets were counted using a coulter counter particle analyser. Results: The addition of the high molecular weight polymer increased shear viscosity and viscoelasticity of the oil blends, which were measureable and to some extent predictable. The in vitro emulsification models produced contradictory results. This demonstrates the difficulty of designing and using in vitro models to evaluate the emulsification tendency of tamponade agents in vivo. Conclusion: Addition of a high molecular weight polymer to heavy silicone oil can increase the viscoelasticity. These findings might contribute to the development of emulsification resistant heavy silicone oils.-
dc.languageeng-
dc.publisherSage Publications Ltd.. The Journal's web site is located at http://jba.sagepub.com/-
dc.relation.ispartofJournal of Biomaterials Applications-
dc.rightsJournal of Biomaterials Applications. Copyright © Sage Publications Ltd..-
dc.subjectEmulsification-
dc.subjectOphthalmology-
dc.subjectRetinal detachment-
dc.subjectSilicone oil-
dc.subjectTamponade-
dc.titleDevelopment Of Emulsification Resistant Heavier-than-water Tamponades Using High Molecular Weight Silicone Oil Polymers-
dc.typeArticle-
dc.identifier.emailChan, YK: josephyk@connect.hku.hk-
dc.identifier.emailWong, DSH: shdwong@hku.hk-
dc.identifier.authorityChan, YK=rp02536-
dc.identifier.authorityWong, DSH=rp00516-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1177/0885328215575623-
dc.identifier.pmid25766038-
dc.identifier.scopuseid_2-s2.0-84936866894-
dc.identifier.hkuros243289-
dc.identifier.volume30-
dc.identifier.issue2-
dc.identifier.spage212-
dc.identifier.epage220-
dc.identifier.isiWOS:000357740000008-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl0885-3282-

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