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Article: Passive Immunotherapy with Dromedary Immune Serum in an Experimental Animal Model for Middle East Respiratory Syndrome Coronavirus Infection

TitlePassive Immunotherapy with Dromedary Immune Serum in an Experimental Animal Model for Middle East Respiratory Syndrome Coronavirus Infection
Authors
Zhao, JPerera, RAPMKayali, GMeyerholz, DPerlman, SPeiris, JSMSandri-Goldin, RM
Issue Date2015
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal of Virology, 2015, v. 89 n. 11, p. 6117-6120 How to Cite?
DOI: http://dx.doi.org/10.1128/JVI.00446-15
AbstractMiddle East respiratory syndrome (MERS) is a highly lethal pulmonary infection. Serum from convalescent MERS patients may provide some benefit but is not readily available. In contrast, nearly all camels in the Middle East have been infected with MERS-CoV. Here, we show that sera obtained from MERS-immune camels augment the kinetics of MERS-CoV clearance and reduce the severity of pathological changes in infected lungs, with efficacy proportional to the titer of MERS-CoV-neutralizing serum antibody.
Persistent Identifierhttp://hdl.handle.net/10722/209992
ISSN
0022-538X
2022 Impact Factor: 5.4
2020 SCImago Journal Rankings: 2.617
ISI Accession Number ID
WOS:000353907900032

 

DC FieldValueLanguage
dc.contributor.authorZhao, J-
dc.contributor.authorPerera, RAPM-
dc.contributor.authorKayali, G-
dc.contributor.authorMeyerholz, D-
dc.contributor.authorPerlman, S-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorSandri-Goldin, RM-
dc.date.accessioned2015-05-18T03:39:19Z-
dc.date.available2015-05-18T03:39:19Z-
dc.date.issued2015-
dc.identifier.citationJournal of Virology, 2015, v. 89 n. 11, p. 6117-6120-
dc.identifier.issn0022-538X-
dc.identifier.urihttp://hdl.handle.net/10722/209992-
dc.description.abstractMiddle East respiratory syndrome (MERS) is a highly lethal pulmonary infection. Serum from convalescent MERS patients may provide some benefit but is not readily available. In contrast, nearly all camels in the Middle East have been infected with MERS-CoV. Here, we show that sera obtained from MERS-immune camels augment the kinetics of MERS-CoV clearance and reduce the severity of pathological changes in infected lungs, with efficacy proportional to the titer of MERS-CoV-neutralizing serum antibody.-
dc.languageeng-
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/-
dc.relation.ispartofJournal of Virology-
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.-
dc.titlePassive Immunotherapy with Dromedary Immune Serum in an Experimental Animal Model for Middle East Respiratory Syndrome Coronavirus Infection-
dc.typeArticle-
dc.identifier.emailPerera, RAPM: mahenp@hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.authorityPerera, RAPM=rp02500-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1128/JVI.00446-15-
dc.identifier.pmid25787284-
dc.identifier.scopuseid_2-s2.0-84929619188-
dc.identifier.hkuros243343-
dc.identifier.volume89-
dc.identifier.issue11-
dc.identifier.spage6117-
dc.identifier.epage6120-
dc.identifier.isiWOS:000353907900032-
dc.publisher.placeUnited States-
dc.identifier.issnl0022-538X-

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