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Article: An Electrophoresis-Aided Biomineralization System for Regenerating Dentin- and Enamel-Like Microstructures for the Self-Healing of Tooth Defects

TitleAn Electrophoresis-Aided Biomineralization System for Regenerating Dentin- and Enamel-Like Microstructures for the Self-Healing of Tooth Defects
Authors
KeywordsDentin
Enamel
Remineralization
Collagen
Electrophoresis
Issue Date2014
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/crystal
Citation
Crystal Growth & Design, 2014, v. 14 n. 11, p. 5537-5548 How to Cite?
AbstractIt is the challenging and desirable aim of biomineralization studies to regenerate tooth tissue microstructures and to accelerate the speed of available biomimetic remineralization protocols for potential use in clinical dentistry. In this study, we developed a novel electrophoresis-aided calcium and phosphate agarose hydrogel system that can be used to quickly regenerate tooth tissue microstructure. After remineralization for 12 h, a demineralized dentin collagen matrix was remineralized with intrafibrillar and interfibrillar hydroxyapatites that mimicked the structure of the original calcified dentin collagen matrix. The precipitated hydroxyapatites were densely packed, occluded the exposed dentinal tubules, and regularly and homogeneously distributed along the collagen fibrils in a “string-of-beads” structure within the dentin collagen matrix. Needle-like hydroxyapatite crystals were densely packed, with their c-axis parallel to one another, to form the enamel-like tissue that precipitated onto the remineralized dentin surface. This study provides a potential protocol for inducing the self-healing of dentin defects.
Persistent Identifierhttp://hdl.handle.net/10722/209776
ISSN
2021 Impact Factor: 4.010
2020 SCImago Journal Rankings: 0.966
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWu, X-
dc.contributor.authorCao, Y-
dc.contributor.authorMei, L-
dc.contributor.authorChen, J-
dc.contributor.authorLi, Q-
dc.contributor.authorChu, CH-
dc.date.accessioned2015-05-18T03:21:55Z-
dc.date.available2015-05-18T03:21:55Z-
dc.date.issued2014-
dc.identifier.citationCrystal Growth & Design, 2014, v. 14 n. 11, p. 5537-5548-
dc.identifier.issn1528-7483-
dc.identifier.urihttp://hdl.handle.net/10722/209776-
dc.description.abstractIt is the challenging and desirable aim of biomineralization studies to regenerate tooth tissue microstructures and to accelerate the speed of available biomimetic remineralization protocols for potential use in clinical dentistry. In this study, we developed a novel electrophoresis-aided calcium and phosphate agarose hydrogel system that can be used to quickly regenerate tooth tissue microstructure. After remineralization for 12 h, a demineralized dentin collagen matrix was remineralized with intrafibrillar and interfibrillar hydroxyapatites that mimicked the structure of the original calcified dentin collagen matrix. The precipitated hydroxyapatites were densely packed, occluded the exposed dentinal tubules, and regularly and homogeneously distributed along the collagen fibrils in a “string-of-beads” structure within the dentin collagen matrix. Needle-like hydroxyapatite crystals were densely packed, with their c-axis parallel to one another, to form the enamel-like tissue that precipitated onto the remineralized dentin surface. This study provides a potential protocol for inducing the self-healing of dentin defects.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/crystal-
dc.relation.ispartofCrystal Growth & Design-
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/cg5007633.-
dc.subjectDentin-
dc.subjectEnamel-
dc.subjectRemineralization-
dc.subjectCollagen-
dc.subjectElectrophoresis-
dc.titleAn Electrophoresis-Aided Biomineralization System for Regenerating Dentin- and Enamel-Like Microstructures for the Self-Healing of Tooth Defects-
dc.typeArticle-
dc.identifier.emailMei, L: mei1123@hku.hk-
dc.identifier.emailChu, CH: chchu@hku.hk-
dc.identifier.authorityMei, L=rp01840-
dc.identifier.authorityChu, CH=rp00022-
dc.description.naturepostprint-
dc.identifier.doi10.1021/cg5007633-
dc.identifier.scopuseid_2-s2.0-84910052450-
dc.identifier.hkuros243296-
dc.identifier.volume14-
dc.identifier.issue11-
dc.identifier.spage5537-
dc.identifier.epage5548-
dc.identifier.eissn1528-7505-
dc.identifier.isiWOS:000344516800026-
dc.publisher.placeUnited States-
dc.identifier.issnl1528-7483-

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