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Article: Clinical severity of human infections with avian influenza A(H7N9) virus, China, 2013/14

TitleClinical severity of human infections with avian influenza A(H7N9) virus, China, 2013/14
Authors
Issue Date2014
PublisherEuropean Centre for Disease Prevention and Control. The Journal's web site is located at http://www.eurosurveillance.org/Public/AboutUs/AboutUs.aspx
Citation
Eurosurveillance, 2014, v. 19 n. 49, article no. 20984 How to Cite?
AbstractAssessing the severity of emerging infections is challenging because of potential biases in case ascertainment. The first human case of infection with influenza A(H7N9) virus was identified in China in March 2013; since then, the virus has caused two epidemic waves in the country. There were 134 laboratory-confirmed cases detected in the first epidemic wave from January to September 2013. In the second epidemic wave of human infections with avian influenza A(H7N9) virus in China from October 2013 to October 2014, we estimated that the risk of death among hospitalised cases of infection with influenza A(H7N9) virus was 48% (95% credibility interval: 42-54%), slightly higher than the corresponding risk in the first wave. Age-specific risks of death among hospitalised cases were also significantly higher in the second wave. Using data on symptomatic cases identified through national sentinel influenza-like illness surveillance, we estimated that the risk of death among symptomatic cases of infection with influenza A(H7N9) virus was 0.10% (95% credibility interval: 0.029-3.6%), which was similar to previous estimates for the first epidemic wave of human infections with influenza A(H7N9) virus in 2013. An increase in the risk of death among hospitalised cases in the second wave could be real because of changes in the virus, because of seasonal changes in host susceptibility to severe infection, or because of variation in treatment practices between hospitals, while the increase could be artefactual because of changes in ascertainment of cases in different areas at different times.
Persistent Identifierhttp://hdl.handle.net/10722/209418
ISSN
2023 Impact Factor: 9.9
2023 SCImago Journal Rankings: 2.881
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFeng, L-
dc.contributor.authorWu, JT-
dc.contributor.authorLiu, X-
dc.contributor.authorYang, P-
dc.contributor.authorTsang, TK-
dc.contributor.authorJiang, H-
dc.contributor.authorWu, P-
dc.contributor.authorYang, J-
dc.contributor.authorFang, VJ-
dc.contributor.authorQin, Y-
dc.contributor.authorLau, EHY-
dc.contributor.authorLi, M-
dc.contributor.authorZheng, J-
dc.contributor.authorPeng, Z-
dc.contributor.authorXie, Y-
dc.contributor.authorWang, Q-
dc.contributor.authorLi, Z-
dc.contributor.authorLeung, GM-
dc.contributor.authorGao, GF-
dc.contributor.authorYu, H-
dc.contributor.authorCowling, BJ-
dc.date.accessioned2015-04-17T05:15:48Z-
dc.date.available2015-04-17T05:15:48Z-
dc.date.issued2014-
dc.identifier.citationEurosurveillance, 2014, v. 19 n. 49, article no. 20984-
dc.identifier.issn1025-496X-
dc.identifier.urihttp://hdl.handle.net/10722/209418-
dc.description.abstractAssessing the severity of emerging infections is challenging because of potential biases in case ascertainment. The first human case of infection with influenza A(H7N9) virus was identified in China in March 2013; since then, the virus has caused two epidemic waves in the country. There were 134 laboratory-confirmed cases detected in the first epidemic wave from January to September 2013. In the second epidemic wave of human infections with avian influenza A(H7N9) virus in China from October 2013 to October 2014, we estimated that the risk of death among hospitalised cases of infection with influenza A(H7N9) virus was 48% (95% credibility interval: 42-54%), slightly higher than the corresponding risk in the first wave. Age-specific risks of death among hospitalised cases were also significantly higher in the second wave. Using data on symptomatic cases identified through national sentinel influenza-like illness surveillance, we estimated that the risk of death among symptomatic cases of infection with influenza A(H7N9) virus was 0.10% (95% credibility interval: 0.029-3.6%), which was similar to previous estimates for the first epidemic wave of human infections with influenza A(H7N9) virus in 2013. An increase in the risk of death among hospitalised cases in the second wave could be real because of changes in the virus, because of seasonal changes in host susceptibility to severe infection, or because of variation in treatment practices between hospitals, while the increase could be artefactual because of changes in ascertainment of cases in different areas at different times.-
dc.languageeng-
dc.publisherEuropean Centre for Disease Prevention and Control. The Journal's web site is located at http://www.eurosurveillance.org/Public/AboutUs/AboutUs.aspx-
dc.relation.ispartofEurosurveillance-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleClinical severity of human infections with avian influenza A(H7N9) virus, China, 2013/14-
dc.typeArticle-
dc.identifier.emailWu, JT: joewu@hku.hk-
dc.identifier.emailTsang, TK: matklab@hku.hk-
dc.identifier.emailWu, P: pengwu@hku.hk-
dc.identifier.emailFang, VJ: vickyf@hku.hk-
dc.identifier.emailLau, EHY: ehylau@hku.hk-
dc.identifier.emailLeung, GM: gmleung@hku.hk-
dc.identifier.emailCowling, BJ: bcowling@hku.hk-
dc.identifier.authorityWu, JT=rp00517-
dc.identifier.authorityTsang, TK=rp02571-
dc.identifier.authorityWu, P=rp02025-
dc.identifier.authorityLau, EHY=rp01349-
dc.identifier.authorityLeung, GM=rp00460-
dc.identifier.authorityCowling, BJ=rp01326-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.2807/1560-7917.es2014.19.49.20984-
dc.identifier.pmid25523971-
dc.identifier.pmcidPMC4454636-
dc.identifier.scopuseid_2-s2.0-84919742795-
dc.identifier.hkuros242872-
dc.identifier.volume19-
dc.identifier.issue49-
dc.identifier.spagearticle no. 20984-
dc.identifier.epagearticle no. 20984-
dc.identifier.isiWOS:000346494800004-
dc.publisher.placeSweden-
dc.identifier.issnl1025-496X-

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