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- Publisher Website: 10.1017/S0950268814000855
- Scopus: eid_2-s2.0-84921437105
- PMID: 24786933
- WOS: WOS:000348646700012
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Article: Multivariate analysis of factors affecting the immunogenicity of trivalent inactivated influenza vaccine in school-age children
Title | Multivariate analysis of factors affecting the immunogenicity of trivalent inactivated influenza vaccine in school-age children |
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Authors | |
Keywords | Immunization (vaccination) influenza serology statistics |
Issue Date | 2015 |
Publisher | Cambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=HYG |
Citation | Epidemiology and Infection, 2015, v. 143 n. 3, p. 540-549 How to Cite? |
Abstract | We examined factors affecting the immunogenicity of trivalent inactivated influenza vaccination (TIV) in children using the antibody titres of children participating in a Hong Kong community-based study. Antibody titres of strains included in the 2009-2010 northern hemisphere TIV [seasonal A(H1N1), seasonal A(H3N2) and B (Victoria lineage)] and those not included in the TIV [2009 pandemic A(H1N1) and B (Yamagata lineage)] were measured by haemagglutination inhibition immediately before and 1 month after vaccination. Multivariate regression models were fitted in a Bayesian framework to characterize the distribution of changes in antibody titres following vaccination. Statistically significant rises in geometric mean antibody titres were observed against all strains, with a wide variety of standard deviations and correlations in rises observed, with the influenza type B antibodies showing more variability than the type A antibodies. The dynamics of antibody titres after vaccination can be used in more complex models of antibody dynamics in populations. |
Persistent Identifier | http://hdl.handle.net/10722/209411 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.830 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Freeman, G | - |
dc.contributor.author | Ng, S | - |
dc.contributor.author | Perera, RAPM | - |
dc.contributor.author | Fang, J | - |
dc.contributor.author | Ip, DKM | - |
dc.contributor.author | Leung, GM | - |
dc.contributor.author | Peiris, JSM | - |
dc.contributor.author | Cowling, BJ | - |
dc.date.accessioned | 2015-04-17T05:15:47Z | - |
dc.date.available | 2015-04-17T05:15:47Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Epidemiology and Infection, 2015, v. 143 n. 3, p. 540-549 | - |
dc.identifier.issn | 0950-2688 | - |
dc.identifier.uri | http://hdl.handle.net/10722/209411 | - |
dc.description.abstract | We examined factors affecting the immunogenicity of trivalent inactivated influenza vaccination (TIV) in children using the antibody titres of children participating in a Hong Kong community-based study. Antibody titres of strains included in the 2009-2010 northern hemisphere TIV [seasonal A(H1N1), seasonal A(H3N2) and B (Victoria lineage)] and those not included in the TIV [2009 pandemic A(H1N1) and B (Yamagata lineage)] were measured by haemagglutination inhibition immediately before and 1 month after vaccination. Multivariate regression models were fitted in a Bayesian framework to characterize the distribution of changes in antibody titres following vaccination. Statistically significant rises in geometric mean antibody titres were observed against all strains, with a wide variety of standard deviations and correlations in rises observed, with the influenza type B antibodies showing more variability than the type A antibodies. The dynamics of antibody titres after vaccination can be used in more complex models of antibody dynamics in populations. | - |
dc.language | eng | - |
dc.publisher | Cambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=HYG | - |
dc.relation.ispartof | Epidemiology and Infection | - |
dc.rights | Epidemiology and Infection. Copyright © Cambridge University Press. | - |
dc.subject | Immunization (vaccination) | - |
dc.subject | influenza | - |
dc.subject | serology | - |
dc.subject | statistics | - |
dc.title | Multivariate analysis of factors affecting the immunogenicity of trivalent inactivated influenza vaccine in school-age children | - |
dc.type | Article | - |
dc.identifier.email | Perera, RAPM: mahenp@hku.hk | - |
dc.identifier.email | Fang, J: vickyf@hku.hk | - |
dc.identifier.email | Ip, DKM: dkmip@hku.hk | - |
dc.identifier.email | Leung, GM: gmleung@hku.hk | - |
dc.identifier.email | Peiris, JSM: malik@hkucc.hku.hk | - |
dc.identifier.email | Cowling, BJ: bcowling@hku.hk | - |
dc.identifier.authority | Freeman, G=rp01694 | - |
dc.identifier.authority | Perera, RAPM=rp02500 | - |
dc.identifier.authority | Ip, DKM=rp00256 | - |
dc.identifier.authority | Leung, GM=rp00460 | - |
dc.identifier.authority | Peiris, JSM=rp00410 | - |
dc.identifier.authority | Cowling, BJ=rp01326 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1017/S0950268814000855 | - |
dc.identifier.pmid | 24786933 | - |
dc.identifier.scopus | eid_2-s2.0-84921437105 | - |
dc.identifier.hkuros | 242824 | - |
dc.identifier.volume | 143 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 540 | - |
dc.identifier.epage | 549 | - |
dc.identifier.isi | WOS:000348646700012 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0950-2688 | - |