File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Longitudinal changes in retinal nerve fibre layer thickness after an isolated unilateral retrobulbar optic neuritis: 1-Year results

TitleLongitudinal changes in retinal nerve fibre layer thickness after an isolated unilateral retrobulbar optic neuritis: 1-Year results
Authors
KeywordsOCT
Optic neuritis
Optical coherence tomography
RNFL
Steroid
Issue Date2015
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/01658107.asp
Citation
Neuro-Ophthalmology, 2015, v. 39 n. 1, p. 22-25 How to Cite?
AbstractThe objective of this study was to investigate the longitudinal changes in retinal nerve fibre layer (RNFL) thickness 1 year after an episode of unilateral acute optic neuritis. This prospective cohort study recruited consecutive patients with a first episode of isolated, unilateral acute optic neuritis from October 2010 to June 2013. RNFL thickness of the attack and normal fellow eyes was measured by optical coherence tomography on presentation and 3, 6, and 12 months post attack in both the treatment and non-treatment groups. The treatment group consisted of subjects that opted for systemic steroids to hasten recovery time. In 20 subjects, 11 received systemic steroids and 9 were treated conservatively. The baseline RNFL thickness was similar in the attack and fellow eyes (p≥0.4). Progressive RNFL thinning was seen in the attack eye over the 12-month period, with significant differences for baseline versus 3 months; baseline versus 12 months; and 3 versus 12 months (all p<0.0001). At 12 months, the attack eye had a thinner average RNFL than the fellow eye (100.9±6.1 versus 107.3±5.5 μm; p=0.002). The 12-month RNFL was similar between the treatment and non-treatment groups (p≥0.6). A single episode of optic neuritis triggered an accelerated, progressive RNFL thinning up to 6 months post attack. Initial treatment with systemic steroids did not seem to alter the degree of RNFL loss at 12 months.
Persistent Identifierhttp://hdl.handle.net/10722/208470
ISSN
2023 Impact Factor: 0.8
2023 SCImago Journal Rankings: 0.284
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYau, GSKen_US
dc.contributor.authorLee, WYJen_US
dc.contributor.authorLau, PPKen_US
dc.contributor.authorTam, VTYen_US
dc.contributor.authorWong, WWYen_US
dc.contributor.authorYuen, CYFen_US
dc.date.accessioned2015-03-11T07:06:13Z-
dc.date.available2015-03-11T07:06:13Z-
dc.date.issued2015en_US
dc.identifier.citationNeuro-Ophthalmology, 2015, v. 39 n. 1, p. 22-25en_US
dc.identifier.issn0165-8107en_US
dc.identifier.urihttp://hdl.handle.net/10722/208470-
dc.description.abstractThe objective of this study was to investigate the longitudinal changes in retinal nerve fibre layer (RNFL) thickness 1 year after an episode of unilateral acute optic neuritis. This prospective cohort study recruited consecutive patients with a first episode of isolated, unilateral acute optic neuritis from October 2010 to June 2013. RNFL thickness of the attack and normal fellow eyes was measured by optical coherence tomography on presentation and 3, 6, and 12 months post attack in both the treatment and non-treatment groups. The treatment group consisted of subjects that opted for systemic steroids to hasten recovery time. In 20 subjects, 11 received systemic steroids and 9 were treated conservatively. The baseline RNFL thickness was similar in the attack and fellow eyes (p≥0.4). Progressive RNFL thinning was seen in the attack eye over the 12-month period, with significant differences for baseline versus 3 months; baseline versus 12 months; and 3 versus 12 months (all p<0.0001). At 12 months, the attack eye had a thinner average RNFL than the fellow eye (100.9±6.1 versus 107.3±5.5 μm; p=0.002). The 12-month RNFL was similar between the treatment and non-treatment groups (p≥0.6). A single episode of optic neuritis triggered an accelerated, progressive RNFL thinning up to 6 months post attack. Initial treatment with systemic steroids did not seem to alter the degree of RNFL loss at 12 months.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/01658107.aspen_US
dc.relation.ispartofNeuro-Ophthalmologyen_US
dc.subjectOCTen_US
dc.subjectOptic neuritisen_US
dc.subjectOptical coherence tomographyen_US
dc.subjectRNFLen_US
dc.subjectSteroiden_US
dc.titleLongitudinal changes in retinal nerve fibre layer thickness after an isolated unilateral retrobulbar optic neuritis: 1-Year resultsen_US
dc.typeArticleen_US
dc.identifier.emailLee, WYJ: jackylee@hku.hken_US
dc.identifier.authorityLee, WYJ=rp01498en_US
dc.identifier.doi10.3109/01658107.2014.984230en_US
dc.identifier.scopuseid_2-s2.0-84921664796-
dc.identifier.volume39en_US
dc.identifier.issue1en_US
dc.identifier.spage22en_US
dc.identifier.epage25en_US
dc.identifier.isiWOS:000435882700004-
dc.identifier.issnl0165-8107-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats