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- Publisher Website: 10.1016/j.jpedsurg.2009.10.066
- Scopus: eid_2-s2.0-75949126938
- PMID: 20152345
- WOS: WOS:000274393900008
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Article: Peritoneal drainage does not stabilize extremely low birth weight infants with perforated bowe: data from the NET trial
Title | Peritoneal drainage does not stabilize extremely low birth weight infants with perforated bowe: data from the NET trial |
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Authors | |
Keywords | Extremely low birth weight infant (ELBW) Necrotizing enterocolitis (NEC) Neonatal laparotomy Peritoneal drain Pneumoperitoneum |
Issue Date | 2010 |
Publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg |
Citation | Journal of Pediatric Surgery, 2010, v. 45 n. 2, p. 324-329 How to Cite? |
Abstract | INTRODUCTION:
Proponents of peritoneal drainage (PD) hypothesize that it allows stabilization before laparotomy. We examined this hypothesis by comparing clinical status before and after either PD or primary laparotomy (LAP).
METHODS:
In an ethically approved, international, prospective randomized controlled trial (2002-2006), extremely low birth weight (<1000 g) infants with pneumoperitoneum received primary PD (n = 35) or LAP (n = 34). Physiologic data were collected prospectively and organ failure scores calculated and compared between preprocedure and day 1 after procedure. Data, expressed as mean +/- SD or median (range), were analyzed using appropriate statistical tests.
RESULTS:
There was no postprocedure improvement in either PD or LAP group comparing heart rate (PD, P = 1.0; LAP, P = .6), blood pressure (PD, P = .6; LAP, P = .8), inotrope requirement (PD, P = .2; LAP, P = .3), or Arterial partial pressure of oxygen/fraction of inspired oxygen ratio (PD, P = .1; LAP, P = .5). Infants managed with PD had a worsening cardiovascular status (P = .05). There were no differences in total organ failure score in either group (PD, P = .5; LAP, P = 1). Only 4 infants survived with PD alone with no difference between preprocedure and postprocedure organ failure score (P = .4).
CONCLUSIONS:
Peritoneal drainage does not immediately improve clinical status in extremely low birth weight infants with bowel perforation. The use of PD as a stabilizing or temporizing measure is not supported by these results.
Copyright 2010 Elsevier Inc. All rights reserved. |
Description | PKH Tam (Queen Mary Hospital, Hong Kong) is one of the memebers in 'The NET Trial Group' |
Persistent Identifier | http://hdl.handle.net/10722/207946 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.949 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Rees, CM | - |
dc.contributor.author | Eaton, S | - |
dc.contributor.author | Khoo, AK | - |
dc.contributor.author | Kiely, EM | - |
dc.contributor.author | Members of the NET Trial Group | - |
dc.contributor.author | Pierro, A | - |
dc.contributor.author | Tam, PKH | - |
dc.date.accessioned | 2015-01-27T02:58:58Z | - |
dc.date.available | 2015-01-27T02:58:58Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Journal of Pediatric Surgery, 2010, v. 45 n. 2, p. 324-329 | - |
dc.identifier.issn | 0022-3468 | - |
dc.identifier.uri | http://hdl.handle.net/10722/207946 | - |
dc.description | PKH Tam (Queen Mary Hospital, Hong Kong) is one of the memebers in 'The NET Trial Group' | - |
dc.description.abstract | INTRODUCTION: Proponents of peritoneal drainage (PD) hypothesize that it allows stabilization before laparotomy. We examined this hypothesis by comparing clinical status before and after either PD or primary laparotomy (LAP). METHODS: In an ethically approved, international, prospective randomized controlled trial (2002-2006), extremely low birth weight (<1000 g) infants with pneumoperitoneum received primary PD (n = 35) or LAP (n = 34). Physiologic data were collected prospectively and organ failure scores calculated and compared between preprocedure and day 1 after procedure. Data, expressed as mean +/- SD or median (range), were analyzed using appropriate statistical tests. RESULTS: There was no postprocedure improvement in either PD or LAP group comparing heart rate (PD, P = 1.0; LAP, P = .6), blood pressure (PD, P = .6; LAP, P = .8), inotrope requirement (PD, P = .2; LAP, P = .3), or Arterial partial pressure of oxygen/fraction of inspired oxygen ratio (PD, P = .1; LAP, P = .5). Infants managed with PD had a worsening cardiovascular status (P = .05). There were no differences in total organ failure score in either group (PD, P = .5; LAP, P = 1). Only 4 infants survived with PD alone with no difference between preprocedure and postprocedure organ failure score (P = .4). CONCLUSIONS: Peritoneal drainage does not immediately improve clinical status in extremely low birth weight infants with bowel perforation. The use of PD as a stabilizing or temporizing measure is not supported by these results. Copyright 2010 Elsevier Inc. All rights reserved. | - |
dc.language | eng | - |
dc.publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg | - |
dc.relation.ispartof | Journal of Pediatric Surgery | - |
dc.subject | Extremely low birth weight infant (ELBW) | - |
dc.subject | Necrotizing enterocolitis (NEC) | - |
dc.subject | Neonatal laparotomy | - |
dc.subject | Peritoneal drain | - |
dc.subject | Pneumoperitoneum | - |
dc.subject.mesh | Drainage - methods | - |
dc.subject.mesh | Enterocolitis, Necrotizing - surgery | - |
dc.subject.mesh | Infant, Extremely Low Birth Weight - physiology | - |
dc.subject.mesh | Intestinal Perforation - surgery | - |
dc.subject.mesh | Laparotomy - methods | - |
dc.title | Peritoneal drainage does not stabilize extremely low birth weight infants with perforated bowe: data from the NET trial | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tam, PKH: paultam@hkucc.hku.hk | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.jpedsurg.2009.10.066 | - |
dc.identifier.pmid | 20152345 | - |
dc.identifier.scopus | eid_2-s2.0-75949126938 | - |
dc.identifier.hkuros | 170756 | - |
dc.identifier.volume | 45 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 324 | - |
dc.identifier.epage | 329 | - |
dc.identifier.isi | WOS:000274393900008 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0022-3468 | - |