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Article: Signaling by purinergic receptors and channels in the pituitary gland

TitleSignaling by purinergic receptors and channels in the pituitary gland
Authors
KeywordsAdenosine Triphosphate - metabolism
Astrocytes - metabolism
Neurons - metabolism
Pituitary Gland - metabolism
Receptors, Purinergic - metabolism
Issue Date2010
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/mce
Citation
Molecular and Cellular Endocrinology, 2010, v. 314 n. 2, p. 184-191 How to Cite?
AbstractAdenosine 5′-triphosphate is frequently released by cells and acts as an agonist for G protein-coupled P2Y receptors and ligand-gated P2X cationic channels in numerous tissues. The breakdown of ATP by ectonucleotidases not only terminates its extracellular messenger functions, but also provides a pathway for the generation of two additional agonists: adenosine 5′-diphosphate, acting via some P2Y receptors, and adenosine, a native agonist for G protein-coupled adenosine receptors. In the pituitary gland, adenosine 5′-triphosphate is released from the endings of magnocellular hypothalamic neurons and by anterior pituitary cells through pathway(s) that are still not well characterized. This gland also expresses several members of each family of purinergic receptors. P2X and adenosine receptors are co-expressed in the somata and nerve terminals of vasopressin-releasing neurons as well as in some secretory pituitary cells. P2X receptors stimulate electrical activity and modulate InsP3-dependent calcium release from intracellular stores, whereas adenosine receptors terminate electrical activity. Calcium-mobilizing P2Y receptors are expressed in pituicytes, folliculo-stellate cells and some secretory cells of the anterior pituitary.
Persistent Identifierhttp://hdl.handle.net/10722/207480
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 1.130
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorStojilkovic, SS-
dc.contributor.authorHe, M-
dc.contributor.authorKoshimizu, TA-
dc.contributor.authorBalik, A-
dc.contributor.authorZemkova, H-
dc.date.accessioned2014-12-29T04:00:54Z-
dc.date.available2014-12-29T04:00:54Z-
dc.date.issued2010-
dc.identifier.citationMolecular and Cellular Endocrinology, 2010, v. 314 n. 2, p. 184-191-
dc.identifier.issn0303-7207-
dc.identifier.urihttp://hdl.handle.net/10722/207480-
dc.description.abstractAdenosine 5′-triphosphate is frequently released by cells and acts as an agonist for G protein-coupled P2Y receptors and ligand-gated P2X cationic channels in numerous tissues. The breakdown of ATP by ectonucleotidases not only terminates its extracellular messenger functions, but also provides a pathway for the generation of two additional agonists: adenosine 5′-diphosphate, acting via some P2Y receptors, and adenosine, a native agonist for G protein-coupled adenosine receptors. In the pituitary gland, adenosine 5′-triphosphate is released from the endings of magnocellular hypothalamic neurons and by anterior pituitary cells through pathway(s) that are still not well characterized. This gland also expresses several members of each family of purinergic receptors. P2X and adenosine receptors are co-expressed in the somata and nerve terminals of vasopressin-releasing neurons as well as in some secretory pituitary cells. P2X receptors stimulate electrical activity and modulate InsP3-dependent calcium release from intracellular stores, whereas adenosine receptors terminate electrical activity. Calcium-mobilizing P2Y receptors are expressed in pituicytes, folliculo-stellate cells and some secretory cells of the anterior pituitary.-
dc.languageeng-
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/mce-
dc.relation.ispartofMolecular and Cellular Endocrinology-
dc.subjectAdenosine Triphosphate - metabolism-
dc.subjectAstrocytes - metabolism-
dc.subjectNeurons - metabolism-
dc.subjectPituitary Gland - metabolism-
dc.subjectReceptors, Purinergic - metabolism-
dc.titleSignaling by purinergic receptors and channels in the pituitary glanden_US
dc.typeArticleen_US
dc.identifier.emailHe, M: hemu@hkucc.hku.hk-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.mce.2009.05.008-
dc.identifier.pmid19467293-
dc.identifier.pmcidPMC2815212-
dc.identifier.scopuseid_2-s2.0-71849100643-
dc.identifier.hkuros165627-
dc.identifier.volume314-
dc.identifier.issue2-
dc.identifier.spage184-
dc.identifier.epage191-
dc.identifier.isiWOS:000274104100005-
dc.publisher.placeIreland-
dc.identifier.issnl0303-7207-

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