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Patent History
- ApplicationUS 12/4078010 2013-11-12
- PublicationUS 20140135271 2014-05-15
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Patent: Lamin A, An Activator of Longevity/Anti-Aging SIRT1 Protein
| Title | Lamin A, An Activator of Longevity/Anti-Aging SIRT1 Protein |
|---|---|
| Priority Date | 2013-11-12 US 12/4078010 2012-11-12 US 12/1725252P |
| Inventors | |
| Issue Date | 2014 |
| Citation | US Published patent application US 20140135271. Washington, DC: US Patent and Trademark Office (USPTO), 2014 How to Cite? |
| Abstract | In one embodiment, the present invention provides methods of modulating the deacetylase activity of SIRT1 in one or more cell by modifying the binding affinity of lamin A to SIRT1 via one or more interaction modifying compound. In another embodiment, the present invention provides methods of screening SIRT1-activating/inhibiting compounds based on the interaction between lamin A and SIRT1 proteins and SIRT1-activating property of lamin A. In another embodiment, the present invention provides uses of SIRT1-activating compounds to treat patient(s) suffering from metabolic and/or aging-related degenerative diseases, and uses of SIRT1-inhibiting compounds to treat human malignancies. |
| Persistent Identifier | http://hdl.handle.net/10722/206620 |
| DC Field | Value | Language |
|---|---|---|
| dc.date.accessioned | 2014-11-21T08:05:33Z | - |
| dc.date.available | 2014-11-21T08:05:33Z | - |
| dc.date.issued | 2014 | en_US |
| dc.identifier.citation | US Published patent application US 20140135271. Washington, DC: US Patent and Trademark Office (USPTO), 2014 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10722/206620 | - |
| dc.description.abstract | In one embodiment, the present invention provides methods of modulating the deacetylase activity of SIRT1 in one or more cell by modifying the binding affinity of lamin A to SIRT1 via one or more interaction modifying compound. In another embodiment, the present invention provides methods of screening SIRT1-activating/inhibiting compounds based on the interaction between lamin A and SIRT1 proteins and SIRT1-activating property of lamin A. In another embodiment, the present invention provides uses of SIRT1-activating compounds to treat patient(s) suffering from metabolic and/or aging-related degenerative diseases, and uses of SIRT1-inhibiting compounds to treat human malignancies. | en_US |
| dc.title | Lamin A, An Activator of Longevity/Anti-Aging SIRT1 Protein | en_US |
| dc.type | Patent | en_US |
| dc.identifier.authority | ZHOU, ZHONGJUN=rp00503 | en_US |
| dc.identifier.authority | LIU, BAOHUA=rp01485 | en_US |
| dc.description.nature | published_or_final_version | en_US |
| dc.contributor.inventor | ZHOU, ZHONGJUN | en_US |
| dc.contributor.inventor | LIU, BAOHUA | en_US |
| patents.identifier.application | US 12/4078010 | en_US |
| patents.description.assignee | UNIV HONG KONG [CN] | en_US |
| patents.description.country | United States of America | en_US |
| patents.date.publication | 2014-05-15 | en_US |
| patents.identifier.hkutechid | Bioch-2012-00445-1 | en_US |
| patents.date.application | 2013-11-12 | en_US |
| patents.date.priority | 2013-11-12 US 12/4078010 | en_US |
| patents.date.priority | 2012-11-12 US 12/1725252P | en_US |
| patents.description.cc | us | en_US |
| patents.identifier.publication | US 20140135271 | en_US |
| patents.relation.family | WO 2014071892 (A1) 2014-05-15 | en_US |
| patents.description.kind | A1 | en_US |