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Conference Paper: The role of c-Myc in regulating HIV-1 Tat protein induced cytokine expression and consequent effects on opportunistic infection
Title | The role of c-Myc in regulating HIV-1 Tat protein induced cytokine expression and consequent effects on opportunistic infection |
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Authors | |
Issue Date | 2013 |
Publisher | American Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org |
Citation | The 2013 Annual Meeting of the American Association of Immunologists (AAI) on Immunology (Immunology 2013), Honolulu, HI., 3-7 May 2013. In Journal of Immunology, 2013, v. 190 meeting abstract suppl., abstract no. 130.17 How to Cite? |
Abstract | The human immunodeficiency virus (HIV-1) trans-activator (Tat) protein is an important viral protein that is known to contribute to the acquired immunodeficiency syndrome (AIDS) pathogenesis via cytokine dysregulation. In this study, we recognized that c-Myc regulated primary blood derived macrophage (PBMac) immune response induced by HIV-1 Tat. Treatment of PBMac with HIV-1 Tat was able to upregulate c-Myc expression in a time dependent manner. We subsequently delineated that HIV-1 Tat regulated c-Myc expression and function through the activation of dsRNA-activated protein kinase (PKR), ERK1/2 and p38 mitogen-activated protein kinase (MAPK). By knocking down the expression of c-Myc with gene specific small-interfering RNA (siRNA), we demonstrated that c-Myc may be critical for the expression of the pro-inflammatory cytokines TNF-α and IL-6. To further investigate the role of c-Myc in AIDS pathogenesis and its effects in the fight against the opportunistic microbes, Mycobacteria avium intracellulare, was used as a pathogen model. Our recent results demonstrated that HIV-1 Tat induced c-Myc to dysregulate cytokine expression, which affects the M. avium intracellular survival in PBMac. In summary, c-Myc may play a significant role in the pathogenesis of AIDS by regulating the cytokine expression by HIV-1 Tat and possibly further enhancing the infection of opportunistic pathogens in AIDS patients. |
Persistent Identifier | http://hdl.handle.net/10722/206055 |
ISSN | 2023 Impact Factor: 3.6 2023 SCImago Journal Rankings: 1.558 |
DC Field | Value | Language |
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dc.contributor.author | Pong, CH | en_US |
dc.contributor.author | Li, CB | en_US |
dc.contributor.author | Yim, HCH | en_US |
dc.contributor.author | Lau, ASY | en_US |
dc.date.accessioned | 2014-10-20T11:47:25Z | - |
dc.date.available | 2014-10-20T11:47:25Z | - |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | The 2013 Annual Meeting of the American Association of Immunologists (AAI) on Immunology (Immunology 2013), Honolulu, HI., 3-7 May 2013. In Journal of Immunology, 2013, v. 190 meeting abstract suppl., abstract no. 130.17 | en_US |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | http://hdl.handle.net/10722/206055 | - |
dc.description.abstract | The human immunodeficiency virus (HIV-1) trans-activator (Tat) protein is an important viral protein that is known to contribute to the acquired immunodeficiency syndrome (AIDS) pathogenesis via cytokine dysregulation. In this study, we recognized that c-Myc regulated primary blood derived macrophage (PBMac) immune response induced by HIV-1 Tat. Treatment of PBMac with HIV-1 Tat was able to upregulate c-Myc expression in a time dependent manner. We subsequently delineated that HIV-1 Tat regulated c-Myc expression and function through the activation of dsRNA-activated protein kinase (PKR), ERK1/2 and p38 mitogen-activated protein kinase (MAPK). By knocking down the expression of c-Myc with gene specific small-interfering RNA (siRNA), we demonstrated that c-Myc may be critical for the expression of the pro-inflammatory cytokines TNF-α and IL-6. To further investigate the role of c-Myc in AIDS pathogenesis and its effects in the fight against the opportunistic microbes, Mycobacteria avium intracellulare, was used as a pathogen model. Our recent results demonstrated that HIV-1 Tat induced c-Myc to dysregulate cytokine expression, which affects the M. avium intracellular survival in PBMac. In summary, c-Myc may play a significant role in the pathogenesis of AIDS by regulating the cytokine expression by HIV-1 Tat and possibly further enhancing the infection of opportunistic pathogens in AIDS patients. | - |
dc.language | eng | en_US |
dc.publisher | American Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org | - |
dc.relation.ispartof | Journal of Immunology | en_US |
dc.rights | This is an author-produced version of a manuscript accepted for publication in The Journal of Immunology (The JI). The American Association of Immunologists, Inc. (The AAI), publisher of The JI, holds the copyright to this manuscript. This manuscript has not yet been copyedited or subjected to editorial proofreading by The JI; hence, it may differ from the final version published in The JI (online and in print). The AAI (The JI) is not liable for errors or omissions in this author-produced version of the manuscript or in any version derived from it by the National Institutes of Health or any other third party. The final, citable version of record can be found at www.jimmunol.org | - |
dc.title | The role of c-Myc in regulating HIV-1 Tat protein induced cytokine expression and consequent effects on opportunistic infection | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Pong, CH: jchpong@hku.hk | en_US |
dc.identifier.email | Li, CB: jamesli@graduate.hku.hk | en_US |
dc.identifier.email | Yim, HCH: chhyim@graduate.hku.hk | en_US |
dc.identifier.email | Lau, ASY: asylau@hku.hk | en_US |
dc.identifier.authority | Li, CB=rp00496 | en_US |
dc.identifier.authority | Lau, ASY=rp00474 | en_US |
dc.identifier.hkuros | 241335 | en_US |
dc.identifier.volume | 190 | - |
dc.identifier.issue | meeting abstract suppl. | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0022-1767 | - |