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Conference Paper: Investigating the role of interleukin-17A on cytokines production by macrophages in response to bacterial infections
Title | Investigating the role of interleukin-17A on cytokines production by macrophages in response to bacterial infections |
---|---|
Authors | |
Issue Date | 2014 |
Publisher | Medcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp |
Citation | The 2014 Joint Annual Scientific Meeting of the Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Hong Kong, China, 15 June 2014. In the Hong Kong Journal of Paediatrics (New series), 2014, v. 19 n. 3, p. 202-203 How to Cite? |
Abstract | Interleukin-17A (IL-17A) has been shown to associate
with a variety of infection diseases. In this study, we
investigate whether IL-17A affects cytokines production
of human peripheral blood-derived macrophages during
Mycobacteriun bovis BCG or Klebsiella pneumoniae
infection. We observed that IL-17A-treated macrophages
exhibited suppressed productions of TNF-α and IL-6 in response to BCG infection. The reduction of cytokines
production was not associated with cell death. On the other
hand, IL-17A promoted TNF-α and IL-6 production by
macrophages during K. pneumoniae infection. Furthermore,
IL-17A did not affect TNF-α production induced by LPS
and Pam3
Cys, which are TLR4 and TLR2 agonists,
respectively. The data suggest that the differential regulation
of cytokines production by IL-17A requires whole
bacterium infection. |
Description | Poster Presentation |
Persistent Identifier | http://hdl.handle.net/10722/206051 |
ISSN | 2023 Impact Factor: 0.1 2023 SCImago Journal Rankings: 0.117 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ling, WL | en_US |
dc.contributor.author | Wang, L | en_US |
dc.contributor.author | Pong, CH | en_US |
dc.contributor.author | Chan, GCF | en_US |
dc.contributor.author | Li, CB | en_US |
dc.date.accessioned | 2014-10-20T11:47:23Z | - |
dc.date.available | 2014-10-20T11:47:23Z | - |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | The 2014 Joint Annual Scientific Meeting of the Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Hong Kong, China, 15 June 2014. In the Hong Kong Journal of Paediatrics (New series), 2014, v. 19 n. 3, p. 202-203 | en_US |
dc.identifier.issn | 1013-9923 | - |
dc.identifier.uri | http://hdl.handle.net/10722/206051 | - |
dc.description | Poster Presentation | - |
dc.description.abstract | Interleukin-17A (IL-17A) has been shown to associate with a variety of infection diseases. In this study, we investigate whether IL-17A affects cytokines production of human peripheral blood-derived macrophages during Mycobacteriun bovis BCG or Klebsiella pneumoniae infection. We observed that IL-17A-treated macrophages exhibited suppressed productions of TNF-α and IL-6 in response to BCG infection. The reduction of cytokines production was not associated with cell death. On the other hand, IL-17A promoted TNF-α and IL-6 production by macrophages during K. pneumoniae infection. Furthermore, IL-17A did not affect TNF-α production induced by LPS and Pam3 Cys, which are TLR4 and TLR2 agonists, respectively. The data suggest that the differential regulation of cytokines production by IL-17A requires whole bacterium infection. | - |
dc.language | eng | en_US |
dc.publisher | Medcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp | - |
dc.relation.ispartof | Hong Kong Journal of Paediatrics (New series) | en_US |
dc.title | Investigating the role of interleukin-17A on cytokines production by macrophages in response to bacterial infections | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Ling, WL: lingwl@graduate.hku.hk | en_US |
dc.identifier.email | Wang, L: vickyw@hku.hk | en_US |
dc.identifier.email | Pong, CH: jchpong@hku.hk | en_US |
dc.identifier.email | Chan, GCF: gcfchan@hku.hk | en_US |
dc.identifier.email | Li, CB: jamesli@graduate.hku.hk | en_US |
dc.identifier.authority | Chan, GCF=rp00431 | en_US |
dc.identifier.authority | Li, CB=rp00496 | en_US |
dc.description.nature | published_or_final_version | - |
dc.identifier.hkuros | 241331 | en_US |
dc.identifier.volume | 19 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 202 | - |
dc.identifier.epage | 203 | - |
dc.publisher.place | Hong Kong | - |
dc.identifier.issnl | 1013-9923 | - |